Skip to main content
SpringerLink
Log in

Photoradiation Therapy of Rodent Tumors

  • Conference paper
Photosensitisation

Part of the book series: NATO ASI Series ((ASIH,volume 15))

  • 336 Accesses

Abstract

The evaluation of a new modality of cancer treatment requires quantitative measurements of tumor- as well as normal tissue response. Since photoradiation therapy (PDT) also involves injection of a photosensitizinq druq, it is important to obtain information about the pharmacoloqy of the druq: blood transport, retention in different tissues, rates and pathways of excretion etc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barel A, Jori G, Perin A, Romandini P, Pagan A and Biffanti S (1986) Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hemato porphyrin in vivo. Cancer Lett. 32: 145–150.

    Google Scholar 

  2. Barr H, Tralau C J, MacRobert A J, Krasner N, Boulos P B and Bown S G (1987) Photodynamic therapy in the normal rat colon with phthalocyanine sensitization. Br.J. Cancer (in press).

    Google Scholar 

  3. Brenbaum M C, Akande S L, Bonnett R, Kaur H, Ioannou S, White R D and Winfield U J (1986) Meso-tetra (hydroxy phenylporphyrins, a new class of potent tumour photosensitisers with favourable selectivity. Br.J.Cancer 54: 717–725.

    Google Scholar 

  4. Bown S G, Tralau, C J, Coleridge Smith P D, Akdemir D and Wieman T J (1986) Photodynamic therapy with porphyrin and phthalocyanine sensitisation: Quantitative studies in normal rat liver. Br.J. Cancer 54: 43–52.

    Google Scholar 

  5. Brasseur N, Ali H, Langlois R, Wagner J R, Rousseau J and van Lier J E (1987) Biological activities of phthalo- cyanines-V. Photodynamic therapy of EMT-6 mammary tumors in mice with sulfonated phthalocyanines. Photochem. Photobiol. 45: 581–586.

    Google Scholar 

  6. Bugelski P J, Porter C W and Dougherty T J (1981) Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse. Cancer Res. 41: 4606–4612.

    Google Scholar 

  7. Canti C, Ricci L, Cantone V, Franco P, Marelli 0, Andreoni A, Cubeddu R and Nicolin A (1983) Hematoporphyrin derivative photoradation therapy in murine solid tumors. Cancer Lett. 21: 233–237.

    Google Scholar 

  8. Christensen T, Wahl A and Smedshammer L (1984). Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture. Br. J. Cancer 50: 85–89.

    Google Scholar 

  9. Cowled P A, Mackenzie L and Forbes I J (1985) Potentiation of photodynamic therapy with haematoporphyrin derivative by glucocorticoids. Cancer Lett. 29: 107–114.

    Google Scholar 

  10. Cowled P A, Mackenzie L and Forbes I J (1987) Pharmacological modulation of photodynamic therapy with hematoporphyrin derivative and light. Cancer Res. 47: 971–974.

    Google Scholar 

  11. Denekamp J (1979) Experimental tumor systems: Standardization of endpoints. Int. J. Rad. Oncol. 5: 1175–1184.

    Google Scholar 

  12. Evensen J F and Moan J (1987) A test of different photo sensitizers for photodynamic treatment of cancer in a murine tumor model. Photochem. Photobiol (in press).

    Google Scholar 

  13. Evensen J F, Sommer S, Rimington C and Moan J (1987) Photodynamic therapy of C3H mouse mammary carcinoma with haematoporphyrin diethers as sensitizers. Br.J. Cancer 55: 483–486 (1987).

    Google Scholar 

  14. Gomer C J and Razum N J (1984) Acute skin response in albino mice following porphyrin photosensitization under oxic and anoxic conditions. Photochem. Photobiol. 40: 435–439.

    Google Scholar 

  15. Gonzales S, Arnfield M R, Meeker B E, Tulip J, Lakey W H, Chapman, J D and McPhee M S (1986) Treatment of Dunning R3327-AT rat prostate tumors with photodynamic therapy in combination with misonidazole Cancer Res. 46: 2858–2862.

    Google Scholar 

  16. Graschew G and Shopova M (1986) Hypoxia, misonidazole and hyperthermia in photodynamic therapy of tumors. Lasers in Med. Sci. Is 181–186.

    Google Scholar 

  17. Graschew G, Shopova M (1986) Photodynamic therapy and irradiation of tumours: Effect of tumour-cell reoxygenation. Lasers in Med. Sci. 1: 193 - 195.

    Google Scholar 

  18. Henderson B W, Waldow S M, Mang T S, Potter R W, Malone P B and Dougherty T J (1985) Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy. Cancer Res. 45: 572–576.

    Google Scholar 

  19. Henderson B W, Waldow S M, Potter W R and Dougherty T J (1985) Interaction of photodynamic therapy and hyperthermia: Tumor response and cell survival studies after treatment of mice in vivo. Cancer Res. 45: 6071–6077.

    Google Scholar 

  20. Hetzel F W and Farmer H (1984) Dose effect relationships in a mouse mammary tumor, pp 583–590 In: Porphyrin Localization and Treatment of Tumors. Doiron D R and Gomer C J (eds) Alan R. Liss Inc. ( New York ).

    Google Scholar 

  21. Jones G C, Kinsey J H, Neel III, and Cortese D A (1984) The effect of cooling on the photodynamic action of hematoporphyrin derivative during interstitial phototherapy of solid tumors. Otolaryngol. Head Neck Surg. 92: 532–536.

    Google Scholar 

  22. Kessel D (1986) Porphyrin-lipoprotein association as a factor in porphyrin localization. Cancer Lett. 33: 183–188.

    Google Scholar 

  23. LeeSee K, Forbes I J and Betts W H (1987) Oxygen dependency of phototoxicity with hematoporphyrin derivative. Photochem. Photobiol. 39: 631–634.

    Google Scholar 

  24. Moan J (1986) Porphyrin photosensitization and phototherapy. Photochem. Photobiol. 43: 681 - 690.

    Google Scholar 

  25. Moan J and Christensen T (1979) Photodynamic inactivation of cancer cells in vitro: Effect of irradiation temperature and dose fractionation. Cancer Lett. 6: 331–335.

    Google Scholar 

  26. Moan J, Peng Q, Evensen J F, Berg K, Western A and Rimington C (1987) Photosensitizing efficiencies, tumor- and cellular uptake of different photosensitizing drugs relevant for photodynamic therapy of cancer. Photochem. Photobiol. (in press).

    Google Scholar 

  27. Moan J, Rimington C, Evensen J F and Western A (1985) Binding of porphyrins to serum proteins pp 193–205. In: Methods in porphyrin photosensitization. Kessel D (ed). Plenum Press (New York).

    Google Scholar 

  28. Moan J and Sommer S (1985) Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. Cancer Res. 45: 1608–1610.

    Google Scholar 

  29. Moore J V, Keene J P and Land E J (1986) Dose-response relationships for photodynamic injury to murine skin. Br.J. Radiol. 59: 257–261.

    Google Scholar 

  30. Peng Q, Evensen J F, Rimington C and Moan J (1987) A comparison of different photosensitizing dyes with respect to uptake in C3H-tumors and tissues of mice. Cancer Lett, (in press).

    Google Scholar 

  31. Reyftman J P, Morliere P, Goldstein S, Santus R, Dubertret L and Lagrange D (1984). Interaction of human low density lipoproteins with porphyrins: A spectroscopic and photochemical study. Photochem. Photobiol. 40: 721–729.

    Google Scholar 

  32. Selman S H, Kreimer-Birnbaum M, Chaudhuri K, Garbo G M,Seaman D A, Keck R W, Ben-Hur E and Rosenthal I (1986). Photodynamic treatment of transplantable bladder tumors in rodents after pretreatment with chloroaluminium tetrasulfophthalocyanine. J.Urol. 136: 141–145.

    Google Scholar 

  33. Star W M, Marijnissen J P A, van den Berg Blok A E and Reinhold H S (1984) Destructive effect of photoradiation on the microcirculation of a rat mammary tumor growing in sandwich observation chambers, pp 637–645. In Porphyrin Localization and Treatment of Tumors. Doiron D R and Gomer C J (Eds.) Alan R Liss, Inc. ( New York ).

    Google Scholar 

  34. Tochner Z, Mitchell J B, Smith P, Harrington F, Glatstein E,Russo D and Russo A (1986) Photodynamic therapy of ascites tumours within the peritoneal cavity. Br.J.Cancer 53: 733–736.

    Google Scholar 

  35. Tralau C J, MacRobert A J, Coleridge-Smith P D, Barr H and Bown S G (1987) Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcoma. Br.J.Cancer 55: 389–395.

    Google Scholar 

  36. Waldow S M and Dougherty T J (1984) Interaction of Hyperthermia and photoradiation therapy. Rad.Res. 97: 380–385.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysics, Institute for Cancer Research, Montebello, 0310, Oslo 3, Norway

    J. Moan & J. F. Evensen

Authors
  1. J. Moan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. F. Evensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratoire de Biophysique, INSERM U 201, CNRS UA 481, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  2. Muséum National d’Histoire Naturelle 61, Rue Buffon, 75005, Paris, France

    Giuliana Moreno

  3. Department of Chemistry and Chemical Engineering, Royal Military College of Canada Kingston, K7K 5LO, Ontario, Canada

    Roy Henry Pottier

  4. Department of Chemistry, Paisley College, PA1 2BE, Paisley, Scottland,UK

    Terence George Truscott

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Moan, J., Evensen, J.F. (1988). Photoradiation Therapy of Rodent Tumors. In: Moreno, G., Pottier, R.H., Truscott, T.G. (eds) Photosensitisation. NATO ASI Series, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73151-8_61

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73151-8_61

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73153-2

  • Online ISBN: 978-3-642-73151-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation