Abstract
The cause of increased cerebrospinal fluid pressure (CSFP) in pseudotumor cerebri (PC) is not known. The clinical features of the disease (headache, papilledema, elevated CSFP with small ventricles and no space-occupying lesions) suggest two potential causes: brain edema or vascular engorgement secondary to loss of normal vascular tone. SAHS and JOYNT (1) showed the presence of “intracellular and extracellular” edema by light microscopy in brain biopsies from 10 patients. However, FOLEY (2) showed a striking increase in cerebral blood flow (CBF) in 3 patients, which was proportional to the increase in CSFP. To resolve this question, CBF, cerebral blood volume (CBV) and oxygen consumption (CMRO2) were measured in patients with PC undergoing diagnostic cerebral angiography.
This work was supported by U.S. PHS Grant No. 5 PO1 HL13851, by Research Grant RR0396 from the Division of Research Resources of the NIH, by Teacher-Investigator Award I F11 HS11059 (Dr. Raichle) and Grant No. PO1 NSL 6833 from the National Institute of Neurological Disease and Stroke, and by NIH Training Grants No. TO1-NS0551 and No. TO1-GM-01747.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
SAHS, A.L., JOYNT, R.J.: Brain swelling of unknown cause. Neurology 6, 791–803 (1956).
FOLEY, J.: Benign forms of intracranial hypertension — “toxic” and “otitic” hydrocephalus. Brain 78, 1–41 (1955).
TER-POGOSSIAN, M.M., EICHLING, J.O., DAVIS, D.O., WELCH, M.J.: The determination of regional cerebral blood flow by means of water labeled with radioactive oxygen-15. Radiology 93, 31–40 (1969).
PHELPS, M.E., GRUBB, R.L., TER-POGOSSIAN, M.M.: In vivo regional cerebral blood volume by X-ray fluorescence: validation of method. J. Appl. Physiol. 35, 741–747 (1973).
TER-POGOSSIAN, M.M., EICHLING, J.O., DAVIS, D.O., WIELCH, M.J., METZGER, J.M.: The measure in vivo of regional cerebral oxygen utilization by means of oxy-hemoglobin labeled with radioactive oxygen-15. J. Clin. Invest. 49, 381–391 (1970).
GRUBB, R.L., PHELPS, M.E., RAICHLE, M.E., TER-POGOSSIAN, M.M.: The effects of arterial blood pressure on the regional cerebral blood volume by X-ray fluorescence. Stroke 4, 390–399 (1973).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Raichle, M.E. et al. (1975). Cerebral Hemodynamics and Metabolism in Pseudotumor Cerebri. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_41
Download citation
DOI: https://doi.org/10.1007/978-3-642-66086-3_41
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66088-7
Online ISBN: 978-3-642-66086-3
eBook Packages: Springer Book Archive