Abstract
The most reliable means of identifying the hormone- secreting cells in the pituitary gland is immunohistochemical staining. This method has been used by various investigators to classify human and animal pituitary tumors. For many years, the classification of pituitary tumors into three types - acidophilic, basophilic, and chromophobic - was based on their staining by dyes, such as hematoxylin and eosin (H and E), periodic acid Schiff (PAS), orange G, aldehyde fuchsin, and erythrosin. It was believed that the chromophobic tumors did not produce hormone. However, immunohistochemical methods have clearly shown that many chromophobic adenomas do produce hormones; for example, almost all prolactin-secreting tumors are chromophobic (Osamura and Watanabe 1976; Osamura et al. 1978, 1980).
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© 1996 Springer-Verlag Berlin Heidelberg
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Osamura, R.Y., Takayama, S. (1996). Histochemical Identification of Hormones in Pituitary Tumors, Rat. In: Jones, T.C., Capen, C.C., Mohr, U. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60996-1_5
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DOI: https://doi.org/10.1007/978-3-642-60996-1_5
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