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Aetiopathogenesis of Bipolar Disorder

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Bipolar Disorder
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Abstract

BD was traditionally conceptualized in the frame of mood (affective) disorders until its separation from unipolar depression by DSM-5. This long history caused much of the research to focus indiscriminately on ‘mood disorders’ by pooling together bipolar and unipolar patients in study samples. Bipolar depression was not studied separately from unipolar for too long, and mania was not the intensive focus of research.

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References

  • Adler CM, DelBello MP, Jarvis K, Levine A, Adams J, Strakowski SM (2007) Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biol Psychiatry 61(6):776–781. doi:10.1016/j.biopsych.2006.05.042

    PubMed  Google Scholar 

  • Akiskal HS, McKinney WT Jr (1973) Depressive disorders: toward a unified hypothesis. Science 182(4107):20–29

    CAS  PubMed  Google Scholar 

  • Altshuler LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F, Mintz J, Cohen MS (2005) Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol Psychiatry 58(10):763–769. doi:10.1016/j.biopsych.2005.09.012

    PubMed  Google Scholar 

  • Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK (2011) Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13(4):406–413. doi:10.1111/j.1399-5618.2011.00936.x

    PubMed  Google Scholar 

  • Anderson AK, Phelps EA (2002) Is the human amygdala critical for the subjective experience of emotion? Evidence of intact dispositional affect in patients with amygdala lesions. J Cogn Neurosci 14(5):709–720. doi:10.1162/08989290260138618

    PubMed  Google Scholar 

  • Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O’Donovan MC, Rujescu D, Werge T, Sklar P, Psychiatric Genomics C, Bipolar D, Schizophrenia Working G, Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM (2013) Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet 9(4):e1003455. doi:10.1371/journal.pgen.1003455

    CAS  PubMed Central  PubMed  Google Scholar 

  • Arango C, Rapado-Castro M, Reig S, Castro-Fornieles J, Gonzalez-Pinto A, Otero S, Baeza I, Moreno C, Graell M, Janssen J, Parellada M, Moreno D, Bargallo N, Desco M (2012) Progressive brain changes in children and adolescents with first-episode psychosis. Arch Gen Psychiatry 69(1):16–26. doi:10.1001/archgenpsychiatry.2011.150

    PubMed  Google Scholar 

  • Askland K, Read C, Moore J (2009) Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet 125(1):63–79. doi:10.1007/s00439-008-0600-y

    CAS  PubMed  Google Scholar 

  • Atmaca M, Ozdemir H, Cetinkaya S, Parmaksiz S, Belli H, Poyraz AK, Tezcan E, Ogur E (2007) Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine. J Psychiatr Res 41(10):821–827. doi:10.1016/j.jpsychires.2006.07.006

    PubMed  Google Scholar 

  • Auer DP, Putz B, Kraft E, Lipinski B, Schill J, Holsboer F (2000) Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 47(4):305–313

    CAS  PubMed  Google Scholar 

  • Avramopoulos D, Lasseter VK, Fallin MD, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Pulver AE (2007) Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene. Genet Med 9(11):745–751. doi:10.1097/GIM.0b013e318159a37c

    CAS  PubMed  Google Scholar 

  • Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W (2012) Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry 17(8):818–826. doi:10.1038/mp.2011.89

    CAS  PubMed Central  PubMed  Google Scholar 

  • Balanza-Martinez V, Tabares-Seisdedos R, Selva-Vera G, Martinez-Aran A, Torrent C, Salazar-Fraile J, Leal-Cercos C, Vieta E, Gomez-Beneyto M (2005) Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: a 3-year follow-up study. Psychother Psychosom 74(2):113–119. doi:10.1159/000083170

    PubMed  Google Scholar 

  • Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL, Mandelkern MA, Bramen J, Voytek B, Woods R, Mazziotta JC, Whybrow PC (2005) Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry 10(5):456–469. doi:10.1038/sj.mp.4001647

    CAS  PubMed  Google Scholar 

  • Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, Trakhtenbroit M, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Soares JC (2007) Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry 62(1):7–16. doi:10.1016/j.biopsych.2006.10.027

    CAS  PubMed Central  PubMed  Google Scholar 

  • Benabarre A, Vieta E, Martinez-Aran A, Garcia-Garcia M, Martin F, Lomena F, Torrent C, Sanchez-Moreno J, Colom F, Reinares M, Brugue E, Valdes M (2005) Neuropsychological disturbances and cerebral blood flow in bipolar disorder. Aust N Z J Psychiatry 39(4):227–234. doi:10.1111/j.1440-1614.2004.01558.x

    PubMed  Google Scholar 

  • Benes FM, Todtenkopf MS, Logiotatos P, Williams M (2000) Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain. J Chem Neuroanat 20(3–4):259–269

    CAS  PubMed  Google Scholar 

  • Benes FM, Vincent SL, Todtenkopf M (2001) The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry 50(6):395–406

    CAS  PubMed  Google Scholar 

  • Benes FM, Walsh J, Bhattacharyya S, Sheth A, Berretta S (2003) DNA fragmentation decreased in schizophrenia but not bipolar disorder. Arch Gen Psychiatry 60(4):359–364. doi:10.1001/archpsyc.60.4.359

    PubMed  Google Scholar 

  • Beneyto M, Meador-Woodruff JH (2008) Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 33(9):2175–2186. doi:10.1038/sj.npp.1301604

    CAS  PubMed  Google Scholar 

  • Beneyto M, Kristiansen LV, Oni-Orisan A, McCullumsmith RE, Meador-Woodruff JH (2007) Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 32(9):1888–1902. doi:10.1038/sj.npp.1301312

    CAS  PubMed  Google Scholar 

  • Berk M, Hallam K, Malhi GS, Henry L, Hasty M, Macneil C, Yucel M, Pantelis C, Murphy B, Vieta E, Dodd S, McGorry PD (2010) Evidence and implications for early intervention in bipolar disorder. J Ment Health 19(2):113–126. doi:10.3109/09638230903469111

    PubMed  Google Scholar 

  • Bertolino A, Frye M, Callicott JH, Mattay VS, Rakow R, Shelton-Repella J, Post R, Weinberger DR (2003) Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry 53(10):906–913

    PubMed  Google Scholar 

  • Bielau H, Steiner J, Mawrin C, Trubner K, Brisch R, Meyer-Lotz G, Brodhun M, Dobrowolny H, Baumann B, Gos T, Bernstein HG, Bogerts B (2007) Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study. Ann N Y Acad Sci 1096:157–169. doi:10.1196/annals.1397.081

    CAS  PubMed  Google Scholar 

  • Bitanihirwe BK, Lim MP, Woo TU (2010) N-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. Bipolar Disord 12(1):95–101. doi:10.1111/j.1399-5618.2009.00785.x

    CAS  PubMed Central  PubMed  Google Scholar 

  • Blumberg HP, Stern E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride PA, Eidelberg D, Kocsis JH, Silbersweig DA (2000) Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry 48(11):1045–1052

    CAS  PubMed  Google Scholar 

  • Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS (2003) A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry 60(6):601–609. doi:10.1001/archpsyc.60.6.601

    PubMed  Google Scholar 

  • Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH (2005) Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology (Berl) 183(3):308–313. doi:10.1007/s00213-005-0156-7

    CAS  Google Scholar 

  • Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS (2006) Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biol Psychiatry 59(7):611–618. doi:10.1016/j.biopsych.2005.08.031

    CAS  PubMed  Google Scholar 

  • Bora E, Fornito A, Yucel M, Pantelis C (2010) Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry 67(11):1097–1105. doi:10.1016/j.biopsych.2010.01.020

    PubMed  Google Scholar 

  • Bouras C, Kovari E, Hof PR, Riederer BM, Giannakopoulos P (2001) Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol 102(4):373–379

    CAS  PubMed  Google Scholar 

  • Brambilla P, Nicoletti MA, Harenski K, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2002) Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects. Neuropsychopharmacology 27(5):792–799. doi:10.1016/S0893-133X(02)00352-4

    PubMed  Google Scholar 

  • Bruno SD, Barker GJ, Cercignani M, Symms M, Ron MA (2004) A study of bipolar disorder using magnetization transfer imaging and voxel-based morphometry. Brain 127(Pt 11):2433–2440. doi:10.1093/brain/awh274

    CAS  PubMed  Google Scholar 

  • Bruno SD, Papadopoulou K, Cercignani M, Cipolotti L, Ron MA (2006) Structural brain correlates of IQ changes in bipolar disorder. Psychol Med 36(5):609–618. doi:10.1017/S0033291706007112

    CAS  PubMed  Google Scholar 

  • Burnet PW, Harrison PJ (2000) Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia. Biol Psychiatry 47(1):80–83

    CAS  PubMed  Google Scholar 

  • Buttner N, Bhattacharyya S, Walsh J, Benes FM (2007) DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia. Schizophr Res 93(1–3):33–41. doi:10.1016/j.schres.2007.01.030

    PubMed Central  PubMed  Google Scholar 

  • Cannon DM, Carson RE, Nugent AC, Eckelman WC, Kiesewetter DO, Williams J, Rollis D, Drevets M, Gandhi S, Solorio G, Drevets WC (2006a) Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder. Arch Gen Psychiatry 63(7):741–747. doi:10.1001/archpsyc.63.7.741

    CAS  PubMed  Google Scholar 

  • Cannon DM, Ichise M, Fromm SJ, Nugent AC, Rollis D, Gandhi SK, Klaver JM, Charney DS, Manji HK, Drevets WC (2006b) Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry 60(3):207–217. doi:10.1016/j.biopsych.2006.05.005

    CAS  PubMed  Google Scholar 

  • Chana G, Landau S, Beasley C, Everall IP, Cotter D (2003) Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry 53(12):1086–1098

    PubMed  Google Scholar 

  • Chang K, Adleman NE, Dienes K, Simeonova DI, Menon V, Reiss A (2004) Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry 61(8):781–792. doi:10.1001/archpsyc.61.8.781

    PubMed  Google Scholar 

  • Chow T, Cummings J (2000) Neuropsychiatry: clinical assessment and approach to diagnosis. In: Sadock B, Sadock V (eds) Comprehensive textbook of psychiatry. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Clinton SM, Meador-Woodruff JH (2004) Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder. Neuropsychopharmacology 29(7):1353–1362. doi:10.1038/sj.npp.1300451

    CAS  PubMed  Google Scholar 

  • Cotter D, Mackay D, Landau S, Kerwin R, Everall I (2001) Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 58(6):545–553

    CAS  PubMed  Google Scholar 

  • Cotter D, Landau S, Beasley C, Stevenson R, Chana G, MacMillan L, Everall I (2002) The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol Psychiatry 51(5):377–386

    CAS  PubMed  Google Scholar 

  • Coyle TR, Kochunov P, Patel RD, Nery FG, Lancaster JL, Mangin JF, Riviere D, Pillow DR, Davis GJ, Nicoletti MA, Serap Monkul E, Fox PT, Soares JC (2006) Cortical sulci and bipolar disorder. Neuroreport 17(16):1739–1742. doi:10.1097/01.wnr.0000239957.53072.f0

    PubMed  Google Scholar 

  • Cross-Disorder Group of the Psychiatric Genomics C, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayes M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisen L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kahler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landen M, Langstrom N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Muhleisen TW, Muir WJ, Muller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nothen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O’Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnstrom K, Reif A, Ribases M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zollner S, International Inflammatory Bowel Disease Genetics C, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O’Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45(9):984–994. doi:10.1038/ng.2711

    CAS  PubMed  Google Scholar 

  • Davanzo P, Thomas MA, Yue K, Oshiro T, Belin T, Strober M, McCracken J (2001) Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 24(4):359–369. doi:10.1016/S0893-133X(00)00207-4

    CAS  PubMed  Google Scholar 

  • Davanzo P, Yue K, Thomas MA, Belin T, Mintz J, Venkatraman TN, Santoro E, Barnett S, McCracken J (2003) Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. Am J Psychiatry 160(8):1442–1452

    PubMed  Google Scholar 

  • Davenport YB, Adland ML, Gold PW, Goodwin FK (1979) Manic-depressive illness: psychodynamic features of multigenerational families. Am J Orthopsychiatry 49(1):24–35

    CAS  PubMed  Google Scholar 

  • Davidson J (1972) Cholinergic-adrenergic hypothesis of mania and depression. Lancet 2(7789):1249

    CAS  PubMed  Google Scholar 

  • Davidson RJ, Irwin W (1999) The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 3(1):11–21

    PubMed  Google Scholar 

  • Dean B, Pavey G, McLeod M, Opeskin K, Keks N, Copolov D (2001) A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann’s Area 9 from subjects with bipolar disorder. J Affect Disord 66(2–3):147–158

    CAS  PubMed  Google Scholar 

  • Di Renzo G, Amoroso S, Taglialatela M, Canzoniero L, Basile V, Fatatis A, Annunziato L (1989) Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion. Eur J Pharmacol 162(2):371–373

    PubMed  Google Scholar 

  • Doris A, Belton E, Ebmeier KP, Glabus MF, Marshall I (2004) Reduction of cingulate gray matter density in poor outcome bipolar illness. Psychiatry Res 130(2):153–159. doi:10.1016/j.pscychresns.2003.09.002

    PubMed  Google Scholar 

  • Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386(6627):824–827. doi:10.1038/386824a0

    CAS  PubMed  Google Scholar 

  • Dunn RT, Kimbrell TA, Ketter TA, Frye MA, Willis MW, Luckenbaugh DA, Post RM (2002) Principal components of the beck depression inventory and regional cerebral metabolism in unipolar and bipolar depression. Biol Psychiatry 51(5):387–399

    CAS  PubMed  Google Scholar 

  • Eastwood SL, Harrison PJ (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull 55(5):569–578

    CAS  PubMed  Google Scholar 

  • Engel GL (1977) The need for a new medical model: a challenge for biomedicine. Science 196(4286):129–136

    CAS  PubMed  Google Scholar 

  • Engel GL (1980) The clinical application of the biopsychosocial model. Am J Psychiatry 137(5):535–544

    CAS  PubMed  Google Scholar 

  • Evans DL, Golden R (1987) The dexamethasone suppression test: a review. In: Loosen P, Nemeroff C (eds) Handbook of clinical psychoneuroendocrinology. Wiley, New York, pp 313–335

    Google Scholar 

  • Farrow TF, Whitford TJ, Williams LM, Gomes L, Harris AW (2005) Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biol Psychiatry 58(9):713–723. doi:10.1016/j.biopsych.2005.04.033

    PubMed  Google Scholar 

  • Fessler RG, Deyo SN, Meltzer HY, Miller RJ (1984) Evidence that the medial and dorsal raphe nuclei mediate serotonergically-induced increases in prolactin release from the pituitary. Brain Res 299(2):231–237

    CAS  PubMed  Google Scholar 

  • Fountoulakis KN, Vieta E (2008) Treatment of bipolar disorder: a systematic review of available data and clinical perspectives. Int J Neuropsychopharmacol 11(7):999–1029. doi:10.1017/S1461145708009231

    CAS  PubMed  Google Scholar 

  • Fountoulakis KN, Iacovides A, Kaprinis S, Kaprinis G (2006) Life events and clinical subtypes of major depression: a cross-sectional study. Psychiatry Res 143(2–3):235–244. doi:10.1016/j.psychres.2005.09.018

    PubMed  Google Scholar 

  • Fountoulakis KN, Vieta E, Siamouli M, Valenti M, Magiria S, Oral T, Fresno D, Giannakopoulos P, Kaprinis GS (2007) Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder. Ann Gen Psychiatry 6:27. doi:10.1186/1744-859X-6-27

    PubMed Central  PubMed  Google Scholar 

  • Fountoulakis KN, Giannakopoulos P, Kovari E, Bouras C (2008a) Assessing the role of cingulate cortex in bipolar disorder: neuropathological, structural and functional imaging data. Brain Res Rev 59(1):9–21. doi:10.1016/j.brainresrev.2008.04.005

    PubMed  Google Scholar 

  • Fountoulakis KN, Grunze H, Panagiotidis P, Kaprinis G (2008b) Treatment of bipolar depression: an update. J Affect Disord 109(1–2):21–34. doi:10.1016/j.jad.2007.10.016

    PubMed  Google Scholar 

  • Fountoulakis KN, Kelsoe JR, Akiskal H (2012) Receptor targets for antidepressant therapy in bipolar disorder: an overview. J Affect Disord 138(3):222–238. doi:10.1016/j.jad.2011.04.043

    CAS  PubMed  Google Scholar 

  • Frye MA, Watzl J, Banakar S, O’Neill J, Mintz J, Davanzo P, Fischer J, Chirichigno JW, Ventura J, Elman S, Tsuang J, Walot I, Thomas MA (2007) Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 32(12):2490–2499. doi:10.1038/sj.npp.1301387

    CAS  PubMed  Google Scholar 

  • Garattini S, Mennini T, Samanin R (1987) From fenfluramine racemate to d-fenfluramine. Specificity and potency of the effects on the serotoninergic system and food intake. Ann N Y Acad Sci 499:156–166

    CAS  PubMed  Google Scholar 

  • Goodwin GM, Cavanagh JT, Glabus MF, Kehoe RF, O’Carroll RE, Ebmeier KP (1997) Uptake of 99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: associations with mania. Br J Psychiatry 170:426–430

    CAS  PubMed  Google Scholar 

  • Green HS, Kane JM (1983) The dexamethasone suppression test in depression. Clin Neuropharmacol 6(1):7–24

    CAS  PubMed  Google Scholar 

  • Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Sadovnick AD, Akiskal HS, Kelsoe JR (2013a) Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder. J Affect Disord 150(3):1031–1040. doi:10.1016/j.jad.2013.05.035

    CAS  PubMed Central  PubMed  Google Scholar 

  • Greenwood TA, Bipolar Genome Study C, Kelsoe JR (2013b) Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. PLoS One 8(1):e53804. doi:10.1371/journal.pone.0053804

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gruber SA, Rogowska J, Yurgelun-Todd DA (2004) Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord 82(2):191–201. doi:10.1016/j.jad.2003.10.010

    PubMed  Google Scholar 

  • Hajek T, Carrey N, Alda M (2005) Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord 7(5):393–403. doi:10.1111/j.1399-5618.2005.00238.x

    PubMed  Google Scholar 

  • Harkness KL, Luther J (2001) Clinical risk factors for the generation of life events in major depression. J Abnorm Psychol 110(4):564–572

    CAS  PubMed  Google Scholar 

  • Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB (2002) The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety 15(3):117–125. doi:10.1002/da.10015

    PubMed  Google Scholar 

  • Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, Yurgelun-Todd D, Zarate C, Kikinis R, Jolesz FA, McCarley RW (1999) Subgenual cingulate cortex volume in first-episode psychosis. Am J Psychiatry 156(7):1091–1093

    CAS  PubMed Central  PubMed  Google Scholar 

  • Houenou J, Wessa M, Douaud G, Leboyer M, Chanraud S, Perrin M, Poupon C, Martinot JL, Paillere-Martinot ML (2007) Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Mol Psychiatry 12(11):1001–1010. doi:10.1038/sj.mp.4002010

    CAS  PubMed  Google Scholar 

  • Itokawa M, Yamada K, Iwayama-Shigeno Y, Ishitsuka Y, Detera-Wadleigh S, Yoshikawa T (2003) Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans. Neurosci Lett 345(1):53–56

    CAS  PubMed  Google Scholar 

  • Janowsky DS, El-Yousefo MK, Davis JM, Sekerke HJ (1972) A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2(7778):632–635

    CAS  PubMed  Google Scholar 

  • Javadapour A, Malhi GS, Ivanovski B, Chen X, Wen W, Sachdev P (2007) Increased anterior cingulate cortex volume in bipolar I disorder. Aust N Z J Psychiatry 41(11):910–916. doi:10.1080/00048670701634978

    PubMed  Google Scholar 

  • Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL (2008) N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine’s antidepressant activity. Neuropsychopharmacology 33(10):2303–2312. doi:10.1038/sj.npp.1301646

    CAS  PubMed  Google Scholar 

  • Kaur S, Sassi RB, Axelson D, Nicoletti M, Brambilla P, Monkul ES, Hatch JP, Keshavan MS, Ryan N, Birmaher B, Soares JC (2005) Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. Am J Psychiatry 162(9):1637–1643. doi:10.1176/appi.ajp.162.9.1637

    PubMed  Google Scholar 

  • Kelsoe JR (2003) Arguments for the genetic basis of the bipolar spectrum. J Affect Disord 73(1–2):183–197

    PubMed  Google Scholar 

  • Kelsoe J (2009) Mood disorders: genetics. In: Sadock B, Sadock V, Ruiz P (eds) Kaplan & Sadock’s comprehensive textbook of psychiatry, 9th edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Kendler KS, Thornton LM, Gardner CO (2000) Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am J Psychiatry 157(8):1243–1251

    CAS  PubMed  Google Scholar 

  • Knable MB (1999) Schizophrenia and bipolar disorder: findings from studies of the Stanley Foundation Brain Collection. Schizophr Res 39(2):149–152; discussion 163

    CAS  PubMed  Google Scholar 

  • Koethe D, Llenos IC, Dulay JR, Hoyer C, Torrey EF, Leweke FM, Weis S (2007) Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression. J Neural Transm 114(8):1055–1063. doi:10.1007/s00702-007-0660-5

    CAS  PubMed  Google Scholar 

  • Kristiansen LV, Meador-Woodruff JH (2005) Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression. Schizophr Res 78(1):87–93. doi:10.1016/j.schres.2005.06.012

    PubMed  Google Scholar 

  • Kruger S, Seminowicz D, Goldapple K, Kennedy SH, Mayberg HS (2003) State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge. Biol Psychiatry 54(11):1274–1283

    PubMed  Google Scholar 

  • Kruger S, Alda M, Young LT, Goldapple K, Parikh S, Mayberg HS (2006) Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings. Am J Psychiatry 163(2):257–264. doi:10.1176/appi.ajp.163.2.257

    PubMed  Google Scholar 

  • Kupfer DJ (1976) REM latency: a psychobiologic marker for primary depressive disease. Biol Psychiatry 11(2):159–174

    CAS  PubMed  Google Scholar 

  • Kutcher S, Marton P, Szalai J, Kennedy B (1992) Specificity of psychoanalytic hypotheses regarding the onset of adolescent psychoses: an empirical test of a psychodynamic model. J Am Acad Child Adolesc Psychiatry 31(4):699–701. doi:10.1097/00004583-199207000-00018; discussion 701–792

    CAS  PubMed  Google Scholar 

  • Lagopoulos J, Hermens DF, Naismith SL, Scott EM, Hickie IB (2012) Frontal lobe changes occur early in the course of affective disorders in young people. BMC Psychiatry 12:4. doi:10.1186/1471-244X-12-4

    PubMed Central  PubMed  Google Scholar 

  • Lennox BR, Jacob R, Calder AJ, Lupson V, Bullmore ET (2004) Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med 34(5):795–802

    CAS  PubMed  Google Scholar 

  • Lim KO, Rosenbloom MJ, Faustman WO, Sullivan EV, Pfefferbaum A (1999) Cortical gray matter deficit in patients with bipolar disorder. Schizophr Res 40(3):219–227

    CAS  PubMed  Google Scholar 

  • Lim CS, Baldessarini RJ, Vieta E, Yucel M, Bora E, Sim K (2013) Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: review of the evidence. Neurosci Biobehav Rev 37(3):418–435. doi:10.1016/j.neubiorev.2013.01.003

    PubMed  Google Scholar 

  • Lin A, Reniers RL, Wood SJ (2013) Clinical staging in severe mental disorder: evidence from neurocognition and neuroimaging. Br J Psychiatry Suppl 54:s11–s17. doi:10.1192/bjp.bp.112.119156

    PubMed  Google Scholar 

  • Lochhead RA, Parsey RV, Oquendo MA, Mann JJ (2004) Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry. Biol Psychiatry 55(12):1154–1162. doi:10.1016/j.biopsych.2004.02.026

    PubMed  Google Scholar 

  • Loeb LR, Loeb FF Jr (1992) A psychodynamic approach to the early diagnosis of manic-depressive disorder in adolescence. Adolesc Psychiatry 18:348–364

    CAS  PubMed  Google Scholar 

  • Lopez-Larson MP, DelBello MP, Zimmerman ME, Schwiers ML, Strakowski SM (2002) Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biol Psychiatry 52(2):93–100

    PubMed  Google Scholar 

  • Louet E, Consoli A, Lucanto R, Duplant N, Bailly-Salin MJ, Lemoigne A, Martin M, Mayer C, Thompson C, Gollier-Briant F, Laurent C, Brunelle J, Bodeau N, Cohen D (2010) Psychodynamic-oriented psychological assessment predicts evolution to schizophrenia at 8-year follow-up in adolescents hospitalized for a manic/mixed episode: interest of an overall subjective rating. J Physiol Paris 104(5):257–262. doi:10.1016/j.jphysparis.2010.08.004

    PubMed  Google Scholar 

  • Lyoo IK, Kim MJ, Stoll AL, Demopulos CM, Parow AM, Dager SR, Friedman SD, Dunner DL, Renshaw PF (2004) Frontal lobe gray matter density decreases in bipolar I disorder. Biol Psychiatry 55(6):648–651. doi:10.1016/j.biopsych.2003.10.017

    PubMed  Google Scholar 

  • Lyoo IK, Sung YH, Dager SR, Friedman SD, Lee JY, Kim SJ, Kim N, Dunner DL, Renshaw PF (2006) Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord 8(1):65–74. doi:10.1111/j.1399-5618.2006.00284.x

    PubMed  Google Scholar 

  • Maas JW (1975) Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression. Arch Gen Psychiatry 32(11):1357–1361

    CAS  PubMed  Google Scholar 

  • Mah L, Zarate CA Jr, Singh J, Duan YF, Luckenbaugh DA, Manji HK, Drevets WC (2007) Regional cerebral glucose metabolic abnormalities in bipolar II depression. Biol Psychiatry 61(6):765–775. doi:10.1016/j.biopsych.2006.06.009

    CAS  PubMed  Google Scholar 

  • Malhi GS, Lagopoulos J, Owen AM, Ivanovski B, Shnier R, Sachdev P (2007) Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study. J Affect Disord 97(1–3):109–122. doi:10.1016/j.jad.2006.06.005

    PubMed  Google Scholar 

  • Marlinge E, Bellivier F, Houenou J (2014) White matter alterations in bipolar disorder: potential for drug discovery and development. Bipolar Disord 16(2):97–112. doi:10.1111/bdi.12135

    CAS  PubMed  Google Scholar 

  • Martucci L, Wong AH, De Luca V, Likhodi O, Wong GW, King N, Kennedy JL (2006) N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: polymorphisms and mRNA levels. Schizophr Res 84(2–3):214–221. doi:10.1016/j.schres.2006.02.001

    PubMed  Google Scholar 

  • McCarthy MJ, Liang S, Spadoni AD, Kelsoe JR, Simmons AN (2014) Whole brain expression of bipolar disorder associated genes: structural and genetic analyses. PLoS One 9(6):e100204. doi:10.1371/journal.pone.0100204

    PubMed Central  PubMed  Google Scholar 

  • McCullumsmith RE, Kristiansen LV, Beneyto M, Scarr E, Dean B, Meador-Woodruff JH (2007) Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder. Brain Res 1127(1):108–118. doi:10.1016/j.brainres.2006.09.011

    CAS  PubMed Central  PubMed  Google Scholar 

  • McDonald C, Bullmore ET, Sham PC, Chitnis X, Wickham H, Bramon E, Murray RM (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 61(10):974–984. doi:10.1001/archpsyc.61.10.974

    PubMed  Google Scholar 

  • Miller CL, Llenos IC, Dulay JR, Weis S (2006) Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 1073–1074:25–37. doi:10.1016/j.brainres.2005.12.056

    PubMed  Google Scholar 

  • Moore CM, Breeze JL, Gruber SA, Babb SM, Frederick BB, Villafuerte RA, Stoll AL, Hennen J, Yurgelun-Todd DA, Cohen BM, Renshaw PF (2000) Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disord 2(3 Pt 2):207–216

    CAS  PubMed  Google Scholar 

  • Moore PB, Shepherd DJ, Eccleston D, Macmillan IC, Goswami U, McAllister VL, Ferrier IN (2001) Cerebral white matter lesions in bipolar affective disorder: relationship to outcome. Br J Psychiatry J Ment Sci 178:172–176

    CAS  Google Scholar 

  • Moore CM, Biederman J, Wozniak J, Mick E, Aleardi M, Wardrop M, Dougherty M, Harpold T, Hammerness P, Randall E, Lyoo IK, Renshaw PF (2007a) Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Affect Disord 99(1–3):19–25. doi:10.1016/j.jad.2006.08.023

    CAS  PubMed Central  PubMed  Google Scholar 

  • Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, Finn CT, Frederick B, Renshaw PF (2007b) Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Am Acad Child Adolesc Psychiatry 46(4):524–534. doi:10.1097/chi.0b013e31802f5f2c

    PubMed Central  PubMed  Google Scholar 

  • Moorhead TW, McKirdy J, Sussmann JE, Hall J, Lawrie SM, Johnstone EC, McIntosh AM (2007) Progressive gray matter loss in patients with bipolar disorder. Biol Psychiatry 62(8):894–900. doi:10.1016/j.biopsych.2007.03.005

    PubMed  Google Scholar 

  • Mueller HT, Meador-Woodruff JH (2004) NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr Res 71(2–3):361–370. doi:10.1016/j.schres.2004.02.016

    PubMed  Google Scholar 

  • Mundo E, Tharmalingham S, Neves-Pereira M, Dalton EJ, Macciardi F, Parikh SV, Bolonna A, Kerwin RW, Arranz MJ, Makoff AJ, Kennedy JL (2003) Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder. Mol Psychiatry 8(2):241–245. doi:10.1038/sj.mp.4001218

    CAS  PubMed  Google Scholar 

  • Musselman DL, Nemeroff CB (1996) Depression and endocrine disorders: focus on the thyroid and adrenal system. Br J Psychiatry Suppl 30:123–128

    PubMed  Google Scholar 

  • Nery FG, Chen HH, Hatch JP, Nicoletti MA, Brambilla P, Sassi RB, Mallinger AG, Keshavan MS, Soares JC (2009) Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study. Bipolar Disord 11(2):145–153. doi:10.1111/j.1399-5618.2009.00662.x

    PubMed  Google Scholar 

  • Nudmamud-Thanoi S, Reynolds GP (2004) The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders. Neurosci Lett 372(1–2):173–177. doi:10.1016/j.neulet.2004.09.035

    CAS  PubMed  Google Scholar 

  • Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, Vawter MP, Kelsoe JR, Psychiatric Genomics Consortium Bipolar G (2014) Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry 71(6):657–664. doi:10.1001/jamapsychiatry.2014.176

    CAS  PubMed  Google Scholar 

  • Oedegaard KJ, Greenwood TA, Lunde A, Fasmer OB, Akiskal HS, Kelsoe JR, Consortium NGIBD (2010) A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. J Affect Disord 122(1–2):14–26. doi:10.1016/j.jad.2009.06.014

    CAS  PubMed  Google Scholar 

  • Ongur D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A 95(22):13290–13295

    CAS  PubMed Central  PubMed  Google Scholar 

  • Pavuluri MN, O’Connor MM, Harral E, Sweeney JA (2007) Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry 62(2):158–167. doi:10.1016/j.biopsych.2006.07.011

    PubMed  Google Scholar 

  • Paykel ES, Rao BM, Taylor CN (1984) Life stress and symptom pattern in out-patient depression. Psychol Med 14(3):559–568

    CAS  PubMed  Google Scholar 

  • Paykel ES, Cooper Z, Ramana R, Hayhurst H (1996) Life events, social support and marital relationships in the outcome of severe depression. Psychol Med 26(1):121–133

    CAS  PubMed  Google Scholar 

  • Peckys D, Hurd YL (2001) Prodynorphin and kappa opioid receptor mRNA expression in the cingulate and prefrontal cortices of subjects diagnosed with schizophrenia or affective disorders. Brain Res Bull 55(5):619–624

    CAS  PubMed  Google Scholar 

  • Post RM, Silberstein SD (1994) Shared mechanisms in affective illness, epilepsy, and migraine. Neurology 44(10 Suppl 7):S37–S47

    CAS  PubMed  Google Scholar 

  • Post RM, Weiss SR (1989) Sensitization, kindling, and anticonvulsants in mania. J Clin Psychiatry 50(Suppl):23–30; discussion 45–47

    PubMed  Google Scholar 

  • Post RM, Weiss SR (1998) Sensitization and kindling phenomena in mood, anxiety, and obsessive-compulsive disorders: the role of serotonergic mechanisms in illness progression. Biol Psychiatry 44(3):193–206

    CAS  PubMed  Google Scholar 

  • Post RM, Weiss SR, Pert A (1984) Differential effects of carbamazepine and lithium on sensitization and kindling. Prog Neuropsychopharmacol Biol Psychiatry 8(3):425–434

    CAS  PubMed  Google Scholar 

  • Post RM, Weiss SR, Pert A (1988) Implications of behavioral sensitization and kindling for stress-induced behavioral change. Adv Exp Med Biol 245:441–463

    CAS  PubMed  Google Scholar 

  • Post RM, Susan R, Weiss B (1992) Sensitization, kindling, and carbamazepine: an update on their implications for the course of affective illness. Pharmacopsychiatry 25(1):41–43. doi:10.1055/s-2007-1014386

    CAS  PubMed  Google Scholar 

  • Quattrone A, Schettini G, di Renzo G, Tedeschi G, Preziosi P (1979) Effect of midbrain raphe lesion or 5,7-dihydroxytryptamine treatment on the prolactin-releasing action of quipazine and D-fenfluramine in rats. Brain Res 174(1):71–79

    CAS  PubMed  Google Scholar 

  • Raedler TJ, Knable MB, Lafargue T, Urbina RA, Egan MF, Pickar D, Weinberger DR (1999) In vivo determination of striatal dopamine D2 receptor occupancy in patients treated with olanzapine. Psychiatry Res 90(2):81–90

    CAS  PubMed  Google Scholar 

  • Ravindran AV, Matheson K, Griffiths J, Merali Z, Anisman H (2002) Stress, coping, uplifts, and quality of life in subtypes of depression: a conceptual frame and emerging data. J Affect Disord 71(1–3):121–130

    PubMed  Google Scholar 

  • Roth RM, Koven NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ (2006) Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport 17(11):1085–1089. doi:10.1097/01.wnr.0000227979.06013.57

    PubMed  Google Scholar 

  • Rowland NE, Carlton J (1986) Neurobiology of an anorectic drug: fenfluramine. Prog Neurobiol 27(1):13–62

    CAS  PubMed  Google Scholar 

  • Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ (2001) Decision-making in mania: a PET study. Brain 124(Pt 12):2550–2563

    CAS  PubMed  Google Scholar 

  • Sassi RB, Brambilla P, Hatch JP, Nicoletti MA, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2004) Reduced left anterior cingulate volumes in untreated bipolar patients. Biol Psychiatry 56(7):467–475. doi:10.1016/j.biopsych.2004.07.005

    PubMed  Google Scholar 

  • Savitz JB, Price JL, Drevets WC (2014) Neuropathological and neuromorphometric abnormalities in bipolar disorder: view from the medial prefrontal cortical network. Neurosci Biobehav Rev 42:132–147. doi:10.1016/j.neubiorev.2014.02.008

    CAS  PubMed  Google Scholar 

  • Scarr E, Pavey G, Sundram S, MacKinnon A, Dean B (2003) Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder. Bipolar Disord 5(4):257–264

    CAS  PubMed  Google Scholar 

  • Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122(5):509–522

    CAS  PubMed  Google Scholar 

  • Seager MA, Huff KD, Barth VN, Phebus LA, Rasmussen K (2004) Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity. Biol Psychiatry 55(11):1103–1109. doi:10.1016/j.biopsych.2004.02.012

    CAS  PubMed  Google Scholar 

  • Seager MA, Barth VN, Phebus LA, Rasmussen K (2005) Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats: implications for bipolar disorder. Psychopharmacology (Berl) 181(1):126–133. doi:10.1007/s00213-005-2198-2

    CAS  Google Scholar 

  • Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lonnqvist J, Nothen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 73(1):49–62. doi:10.1086/376547

    CAS  PubMed Central  PubMed  Google Scholar 

  • Siever LJ, Murphy DL, Slater S, de la Vega E, Lipper S (1984) Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Sci 34(11):1029–1039

    CAS  PubMed  Google Scholar 

  • Silverstone T, McPherson H, Li Q, Doyle T (2003) Deep white matter hyperintensities in patients with bipolar depression, unipolar depression and age-matched control subjects. Bipolar Disord 5(1):53–57

    PubMed  Google Scholar 

  • Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (2008) Whole-genome association study of bipolar disorder. Mol Psychiatry 13(6):558–569. doi:10.1038/sj.mp.4002151

    CAS  PubMed Central  PubMed  Google Scholar 

  • Soares JC, Kochunov P, Monkul ES, Nicoletti MA, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Lancaster J, Fox P (2005) Structural brain changes in bipolar disorder using deformation field morphometry. Neuroreport 16(6):541–544

    PubMed  Google Scholar 

  • Spirtes MA (1976) Lithium levels in monkey and human brain after chronic, therapeutic, oral dosage. Pharmacol Biochem Behav 5(2):143–147

    CAS  PubMed  Google Scholar 

  • Steggles GR (2012) The process of recovery of a schizoaffectively disordered mind: a psychoanalytic theory of the functional psychoses, the psychodynamic pentapointed cognitive construct theory. BMJ Case Rep. doi:10.1136/bcr-2012-006683

    PubMed  Google Scholar 

  • Stokes PE, Stoll PM, Koslow SH, Maas JW, Davis JM, Swann AC, Robins E (1984) Pretreatment DST and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. A multicenter study. Arch Gen Psychiatry 41(3):257–267

    CAS  PubMed  Google Scholar 

  • Strakowski SM, Wilson DR, Tohen M, Woods BT, Douglass AW, Stoll AL (1993) Structural brain abnormalities in first-episode mania. Biol Psychiatry 33(8–9):602–609

    CAS  PubMed  Google Scholar 

  • Strakowski SM, DelBello MP, Zimmerman ME, Getz GE, Mills NP, Ret J, Shear P, Adler CM (2002) Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. Am J Psychiatry 159(11):1841–1847

    PubMed  Google Scholar 

  • Strakowski SM, Adler CM, Holland SK, Mills NP, DelBello MP, Eliassen JC (2005) Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task. Am J Psychiatry 162(9):1697–1705. doi:10.1176/appi.ajp.162.9.1697

    PubMed  Google Scholar 

  • Swanda R, Haaland K, LaRue A (2000) Clinical neuropsychology and intellectual assessment of adults. In: Sadock B, Sadock V (eds) Comprehensive textbook of psychiatry. Lippincott Williams & Wilkins, Philadelphia, pp 689–702

    Google Scholar 

  • Tarsy D, Leopold N, Sax DS (1972) Cholinergic-adrenergic hypothesis of mania and depression. Lancet 2(7787):1153

    CAS  PubMed  Google Scholar 

  • Tekin S, Cummings JL (2002) Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res 53(2):647–654

    PubMed  Google Scholar 

  • Thomas EA, Dean B, Scarr E, Copolov D, Sutcliffe JG (2003) Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder. Mol Psychiatry 8(2):167–175. doi:10.1038/sj.mp.4001223

    CAS  PubMed  Google Scholar 

  • Thomson KC, Hendrie HC (1972) Environmental stress in primary depressive illness. Arch Gen Psychiatry 26(2):130–132

    CAS  PubMed  Google Scholar 

  • Todtenkopf MS, Vincent SL, Benes FM (2005) A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain. Schizophr Res 73(1):79–89. doi:10.1016/j.schres.2004.08.018

    PubMed  Google Scholar 

  • Torgerson CM, Irimia A, Leow AD, Bartzokis G, Moody TD, Jennings RG, Alger JR, Van Horn JD, Altshuler LL (2013) DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. Brain Imag Behav 7(2):129–139. doi:10.1007/s11682-012-9202-3

    Google Scholar 

  • Toro C, Deakin JF (2005) NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr Res 80(2–3):323–330. doi:10.1016/j.schres.2005.07.003

    PubMed  Google Scholar 

  • Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, Knable MB (2005) Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 57(3):252–260. doi:10.1016/j.biopsych.2004.10.019

    CAS  PubMed  Google Scholar 

  • Van Praag M, Leijnse B (1963) Die Bedeutung Dermonoamineoxydashemmung als Antidepressives Prinzip I. Psychopharmacologia 4(1):1–14

    Google Scholar 

  • Vieta E, Locklear J, Gunther O, Ekman M, Miltenburger C, Chatterton ML, Astrom M, Paulsson B (2010) Treatment options for bipolar depression: a systematic review of randomized, controlled trials. J Clin Psychopharmacol 30(5):579–590. doi:10.1097/JCP.0b013e3181f15849

    CAS  PubMed  Google Scholar 

  • Vita A, De Peri L, Sacchetti E (2009) Gray matter, white matter, brain, and intracranial volumes in first-episode bipolar disorder: a meta-analysis of magnetic resonance imaging studies. Bipolar Disord 11(8):807–814. doi:10.1111/j.1399-5618.2009.00759.x

    PubMed  Google Scholar 

  • Webster MJ, O’Grady J, Kleinman JE, Weickert CS (2005) Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 133(2):453–461. doi:10.1016/j.neuroscience.2005.02.037

    CAS  PubMed  Google Scholar 

  • Wellcome Trust Case Control C (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678. doi:10.1038/nature05911

    Google Scholar 

  • Wessa M, Houenou J, Paillere-Martinot ML, Berthoz S, Artiges E, Leboyer M, Martinot JL (2007) Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. Am J Psychiatry 164(4):638–646. doi:10.1176/appi.ajp.164.4.638

    PubMed  Google Scholar 

  • Wilke M, Kowatch RA, DelBello MP, Mills NP, Holland SK (2004) Voxel-based morphometry in adolescents with bipolar disorder: first results. Psychiatry Res 131(1):57–69. doi:10.1016/j.pscychresns.2004.01.004

    PubMed  Google Scholar 

  • Wiste AK, Arango V, Ellis SP, Mann JJ, Underwood MD (2008) Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder. Bipolar Disord 10(3):349–359. doi:10.1111/j.1399-5618.2007.00528.x

    PubMed  Google Scholar 

  • Woo TU, Walsh JP, Benes FM (2004) Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch Gen Psychiatry 61(7):649–657. doi:10.1001/archpsyc.61.7.649

    CAS  PubMed  Google Scholar 

  • Woo TU, Kim AM, Viscidi E (2008a) Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Brain Res 1218:267–277. doi:10.1016/j.brainres.2008.03.092

    CAS  PubMed Central  PubMed  Google Scholar 

  • Woo TU, Shrestha K, Lamb D, Minns MM, Benes FM (2008b) N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Biol Psychiatry 64(9):803–809. doi:10.1016/j.biopsych.2008.04.034

    CAS  PubMed  Google Scholar 

  • Yatham LN, Goldstein JM, Vieta E, Bowden CL, Grunze H, Post RM, Suppes T, Calabrese JR (2005) Atypical antipsychotics in bipolar depression: potential mechanisms of action. J Clin Psychiatry 66(Suppl 5):40–48

    CAS  PubMed  Google Scholar 

  • Young LT, Warsh JJ, Kish SJ, Shannak K, Hornykeiwicz O (1994) Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry 35(2):121–127

    CAS  PubMed  Google Scholar 

  • Zavitsanou K, Katsifis A, Mattner F, Huang XF (2004) Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder. Neuropsychopharmacology 29(3):619–625. doi:10.1038/sj.npp.1300367

    PubMed  Google Scholar 

  • Zavitsanou K, Katsifis A, Yu Y, Huang XF (2005) M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull 65(5):397–403. doi:10.1016/j.brainresbull.2005.02.007

    CAS  PubMed  Google Scholar 

  • Zimmerman ME, DelBello MP, Getz GE, Shear PK, Strakowski SM (2006) Anterior cingulate subregion volumes and executive function in bipolar disorder. Bipolar Disord 8(3):281–288. doi:10.1111/j.1399-5618.2006.00298.x

    PubMed  Google Scholar 

  • Zipursky RB, Seeman MV, Bury A, Langevin R, Wortzman G, Katz R (1997) Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res 26(2–3):85–92

    CAS  PubMed  Google Scholar 

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Fountoulakis, K.N. (2015). Aetiopathogenesis of Bipolar Disorder. In: Bipolar Disorder. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37216-2_13

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