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Toxoplasmose

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Infektionserkrankungen der Schwangeren und des Neugeborenen

Zusammenfassung

Die Toxoplasmose ist eine weltweit vorkommende Zoonose. Sie wird durch das Protozoon Toxoplasma gondii, einen intrazellulären Erreger, hervorgerufen. Der Erreger wurde erstmals im Jahr 1908 als Parasit in einem Nagetier, dem Gondi, nachgewiesen und primär der Gattung der Leishmanien zugeordnet. Die erste Beschreibung einer Erkrankung beim Menschen erfolgte 1923 mit dem nachfolgenden Nachweis einer diaplazentaren Übertragung im Jahr 1939. Ende der 1960er Jahre erfolgte die vollständige Aufklärung des Entwicklungszyklus von Toxoplasma gondii.

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Literatur

  • Azevedo KM, Setubal S, Lopes VG, Camacho LA, Oliveira SA (2010) Congenital toxoplasmosis transmitted by human immunodeficiency-virus infected women. Braz J Infect Dis 14:186–189

    PubMed  Google Scholar 

  • Berrebi A, Kobuch WE, Bessieres MH, Bloom MC, Rolland M, Sarramon MF, Roques C, Fournie A (1994) Termination of pregnancy for maternal toxoplasmosis. Lancet 344:36–39

    Article  PubMed  CAS  Google Scholar 

  • Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, Withers S, Meier P, McLeod R, Toxoplasmosis Study G (2005) Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening. Am J Obstet Gynecol 192:564–571

    Article  PubMed  Google Scholar 

  • Cortina-Borja M, Tan HK, Wallon M, Paul M, Prusa A, Buffolano W, Malm G, Salt A, Freeman K, Petersen E, Gilbert RE (2010) Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study. PLoS Med 7:

    Google Scholar 

  • Djurkovic-Djakovic O (1995) Toxoplasma infection and pathological outcome of pregnancy. Gynecol Obstet Invest 40:36–41

    Article  PubMed  CAS  Google Scholar 

  • Dunn D, Wallon M, Peyron F, Petersen E, Peckham C, Gilbert R (1999) Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet 353:1829–1833

    Article  PubMed  CAS  Google Scholar 

  • Faucher B, Garcia-Meric P, Franck J, Minodier P, Francois P, Gonnet S, L’Ollivier C, Piarroux R (2012) Long-term ocular outcome in congenital toxoplasmosis: a prospective cohort of treated children. J Infect 64:104–109

    Article  PubMed  CAS  Google Scholar 

  • Fernandes RC, Vasconcellos VP, Araujo LC, Medina-Acosta E (2009) Vertical transmission of HIV and toxoplasma by reactivation in a chronically infected woman. Braz J Infect Dis 13:70–71

    Article  PubMed  Google Scholar 

  • Freeman K, Tan HK, Prusa A, Petersen E, Buffolano W, Malm G, Cortina-Borja M, Gilbert R (2008) Predictors of retinochoroiditis in children with congenital toxoplasmosis: European, prospective cohort study. Pediatrics 121:e1215–1222

    Article  PubMed  Google Scholar 

  • Friese K, Schäfer A, Hof H (2003) Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin

    Google Scholar 

  • Friese K, Mörike K, Neumann G, Windorfer A (2009) Arzneimittel in der Schwangerschaft und Stillzeit: Ein Leitfaden für Ärzte und Apotheker. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Gagliuso DJ, Teich SA, Friedman AH, Orellana J (1990) Ocular toxoplasmosis in AIDS patients. Trans Am Ophthalmol Soc 88:63–86 (discussion 86–68)

    PubMed  CAS  Google Scholar 

  • Garcia-Méric P, Franck J, Dumon H, Piarroux R (2010) Management of congenital toxoplasmosis in France: current data. Presse Med 39(5):530–538

    Article  PubMed  Google Scholar 

  • Garly ML, Petersen E, Pedersen C, Lundgren JD, Gerstoft J (1997) Toxoplasmosis in Danish AIDS patients. Scand J Infect Dis 29:597–600

    Article  PubMed  CAS  Google Scholar 

  • Gras L, Wallon M, Pollak A, Cortina-Borja M, Evengard B, Hayde M, Petersen E, Gilbert R (2005) Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centres. Acta Paediatr 94:1721–1731

    Article  PubMed  Google Scholar 

  • Gross U (2004) Prevalence and public-health-aspects of toxoplasmosis. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:692–697

    PubMed  CAS  Google Scholar 

  • Groß U, Roos T, Friese K (2001) Toxoplasmose in der Schwangerschaft. Dt Ärztebl 98:3293–3300

    Google Scholar 

  • Groß U, Hruzik A, Hlobil H (2009) Toxoplasmose und Schwangerschaft. Der Gynäkologe 42:793–798

    Article  Google Scholar 

  • Guerina NG (1994) Congenital infection with Toxoplasma gondii. Pediatr Ann 23:147–151

    Google Scholar 

  • Hahn H, Kaufmann SHE, Schulz TF, Suerbaum S (2009) Medizinische Mikrobiologie und Infektiologie. Springer, Heidelberg

    Book  Google Scholar 

  • Hlobil H, Gültig K, Naser K, Nötzel K (1992) Konnatale Toxoplasma-Infektionen in Baden-Württemberg. Klin Lab :679–686

    Google Scholar 

  • Hotop A, Hlobil H, Gross U (2012) Efficacy of rapid treatment initiation following primary Toxoplasma gondii infection during pregnancy. Clin Infect Dis 54(11):1545–1552

    Article  PubMed  CAS  Google Scholar 

  • Jones MH, Sever JL, Baker TH, Hallatt JH, Goldenberg ED, Justus KM, Gilkeson MR (1969) Toxoplasmosis and abortion. Am J Obstet Gynecol 104:919–920

    PubMed  CAS  Google Scholar 

  • Jones JL, Dargelas V, Roberts J, Press C, Remington JS, Montoya JG (2009) Risk factors for Toxoplasma gondii infection in the United States. Clin Infect Dis 49:878–884

    Article  PubMed  Google Scholar 

  • Jones JL, Krueger A, Schulkin J, Schantz PM (2010) Toxoplasmosis prevention and testing in pregnancy, survey of obstetrician-gynaecologists. Zoonoses. Public Health 57:27–33

    CAS  Google Scholar 

  • Kaiser K, van Loon AM, Pelloux H, Ferrandiz J, Picot S, Wallace P, Peyron F (2007) Multicenter proficiency study for detection of Toxoplasma gondii in amniotic fluid by nucleic amplification methods. Clinica Chimica Acta 375:99–103

    Article  CAS  Google Scholar 

  • Kieffer F, Wallon M, Garcia P, Thulliez P, Peyron F, Franck J (2008) Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosis. Pediatr Infect Dis J 27:27–32

    Article  PubMed  Google Scholar 

  • Lago EG, Conrado GS, Piccoli CS, Carvalho RL, Bender AL (2009) Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis. Eur J Clin Microbiol Infect Dis 28:345–351

    Article  PubMed  CAS  Google Scholar 

  • McLeod R, Boyer K, Karrison T, Kasza K, Swisher C, Roizen N, Jalbrzikowski J, Remington J, Heydemann P, Noble AG, Mets M, Holfels E, Withers S, Latkany P, Meier P (2006) Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis 42:1383–1394

    Article  PubMed  Google Scholar 

  • Meroni V, Genco F (2008) Toxoplasmosis in pregnancy: evaluation of diagnostic methods. Parassitologia 50:51–53

    PubMed  CAS  Google Scholar 

  • Montoya JG, Liesenfeld O (2004) Toxoplasmosis. Lancet 363:1965–1976

    Article  PubMed  CAS  Google Scholar 

  • Mylonas I, Friese K (2009) Infektionen in der Gynäkologie und Geburtshilfe. Elsevier Verlag – Urban, München

    Google Scholar 

  • Olariu TR, Remington JS, McLeod R, Alam A, Montoya JG (2011) Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants. Pediatr Infect Dis J 30(12):1056–1061

    Article  PubMed  Google Scholar 

  • Pappas G, Roussos N, Falagas ME (2009) Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 39:1385–1394

    Article  PubMed  Google Scholar 

  • Petersen E (2007) Prevention and treatment of congenital toxoplasmosis. Expert Rev Anti Infect Ther 5:285–293

    Article  PubMed  Google Scholar 

  • Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A, Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M, Roizen N, Cezar S, Remington J, Meier P, McLeod R (2008) Longitudinal study of new eye lesions in treated congenital toxoplasmosis. Ophthalmology 115:553–559 (e558)

    Article  PubMed  Google Scholar 

  • Reiter-Owona I (2005) Laboratory diagnosis of toxoplasmosis - possibilities and Limitations. J Lab Med 29:439–445

    CAS  Google Scholar 

  • Remington J, McLeod R, Thulliez P, Desmonts G (2006) Toxoplasmosis. In: Remington J, Klein J, Wilson C, Baker C (Hrsg) Infectious diseases of the fetus and newborn infant, 6. Aufl. Elsevier Saunders,

    Google Scholar 

  • RKI-Ratgeber (2007) Toxoplasmose. Epidemiologischen Bulletin: 40/2007

    Google Scholar 

  • Romand S, Wallon M, Franck J, Thulliez P, Peyron F, Dumon H (2001) Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol 97:296–300

    Article  PubMed  CAS  Google Scholar 

  • Roos T, Martius J, Gross U, Schrod L (1993) Systematic serologic screening for toxoplasmosis in pregnancy. Obstet Gynecol 81:243–250

    PubMed  CAS  Google Scholar 

  • Roser D, Nielsen HV, Petersen E, Saugmann-Jensen P, Norgaard-Pedersen B (2010) Congenital toxoplasmosis--a report on the Danish neonatal screening programme. J Inherit Metab Dis 33:241–247

    Article  Google Scholar 

  • Rudin C, Boubaker K, Raeber PA, Vaudaux B, Bucher C, Garweg JG, Hoesli I, Kind I, Hohlfeld P (2008) Swiss Working Group on congenital Toxoplasmosis. Toxoplasmosis during pregnancy and infancy. A new approach for Switzerland. . Swiss Med Wkly 138:1–8

    Google Scholar 

  • Sanchez VR, Pitkowski MN, Fernandez Cuppari AV, Rodriguez FM, Fenoy IM, Frank FM, Goldman A, Corral RS, Martin V (2011) Combination of CpG-oligodeoxynucleotides with recombinant ROP2 or GRA4 proteins induces protective immunity against Toxoplasma gondii infection. Exp Parasitol 128:448–453

    Article  PubMed  CAS  Google Scholar 

  • Strauss A (2008) Ultraschallpraxis Gynäkologie und Geburtshilfe. Springer, Heidelberg

    Google Scholar 

  • Syrocot, Thiebaut R, Leproust S, Chene G, Gilbert R (2007) Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet 369:115–122

    Article  Google Scholar 

  • Tenter AM, Fehlhaber K (2002) Toxoplasmose: Eine lebensmittelübertragene Parasitose. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 45:549–555

    Article  Google Scholar 

  • Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30:1217–1258

    Article  PubMed  CAS  Google Scholar 

  • Villena I, Ancelle T, Delmas C, Garcia P, Brezin AP, Thulliez P, Wallon M, King L, Goulet V (2010) Congenital toxoplasmosis in France in 2007: first results from a national surveillance system. Euro Surveill 15:

    Google Scholar 

  • Wallon M, Kodjikian L, Binquet C, Garweg J, Fleury J, Quantin C, Peyron F (2004) Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics 113:1567–1572

    Article  PubMed  Google Scholar 

  • Wilson CB, Remington JS, Stagno S, Reynolds DW (1980) Development of adverse sequelae in children born with subclinical congenital Toxoplasma infection. Pediatrics 66:767–774

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik u. Poliklinik f. Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Ludwig-Maximilians-Universität München, Maistraße 11, 80337, München, Deutschland

    Ioannis Mylonas

  2. Zentrum Hygiene und Humangenetik, Institut für Medizinische Mikrobiologie, Universitätsmedizin Göttingen, Kreuzbergring 57, 37075, Göttingen, Deutschland

    Uwe Groß Prof. Dr.

  3. Laborärzte Sindelfingen, Vogelhainweg 4 – 6, 71065, Sindelfingen, Deutschland

    Harald Hlobil Dr. med.

  4. Klinik u. Poliklinik f. Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Ludwig-Maximilians-Universität München, Maistraße 11, 80337, München, Deutschland

    Klaus Friese Prof. Dr. med.

  5. Abteilung für Kinderheilkunde, Allg. Österreichisches Krankenhaus St. Josef Braunau GmbH, Ringstraße 60, 5280, Braunau, Österreich

    Uwe Wintergerst Prim. Prof. Dr. med.

Authors
  1. Ioannis Mylonas
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  2. Uwe Groß Prof. Dr.
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  3. Harald Hlobil Dr. med.
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  4. Klaus Friese Prof. Dr. med.
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  5. Uwe Wintergerst Prim. Prof. Dr. med.
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Editors and Affiliations

  1. Klinik u. Poliklinik f. Frauenheilkunde, und Geburtshilfe, Ludwig-Maximilians-Universität München, Maistraße 11, München, 80337, Germany

    Klaus Friese

  2. Klinikum Innenstadt, Klinik für Geburtshilfe, Ludwig-Maximilians-Universität München, Maistr. 11, München, 80337, Germany

    Ioannis Mylonas

  3. Neonato. im Perinatalzen. Großhadern, Dr. von Haunerschen Kinderspital, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Andreas Schulze

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Mylonas, I., Groß, U., Hlobil, H., Friese, K., Wintergerst, U. (2013). Toxoplasmose. In: Friese, K., Mylonas, I., Schulze, A. (eds) Infektionserkrankungen der Schwangeren und des Neugeborenen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78325-1_37

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  • DOI: https://doi.org/10.1007/978-3-540-78325-1_37

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