Abstract:
Both polyhalogenated hydrocarbons, such as dioxins and related molecules and poly aromatic hydrocarbons (PAHs) are known contaminants of oils and lipids. The toxicity of several of these compounds is well established and limit values have been established. Unfortunately, there is a large gap in our knowledge on the toxic properties of many of these compounds, particularly the PAHs. Therefore it is very difficult to determine the potential health hazards of mixtures of these compounds. For this reason we have developed biological detection methods that are based on the mode of action of these compounds that allow a more direct measurement of potential human health hazards when compared with chemical analysis.
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References
Collins JF, Brown JP, Alexeeff GV, Salmon AG (1998) Potency equivalency factors for some polycyclic aromatic hydrocarbons and polycyclic aromatic hydrocarbon derivatives. Regul Toxicol Pharmacol 28: 45–54.
European Commission (2001) EU White Paper,Strategy for a future chemicals policy. Brussels: Blackwell Publishing.
Garrison PM, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30: 194–203.
Hamers T, van Schaardenburg MD, Felzel EC, Murk AJ, Koeman JH (2000) The application of reporter gene assays for the determination of the toxic potency of diffuse air pollution. Sci Total Environ 262: 159–174.
Jonker MT, Brils JM, Sinke AJ, Murk AJ, Koelmans AA (2006) Weathering and toxicity of marine sediments contaminated with oils and polycyclic aromatic hydrocarbons. Environ Toxicol Chem 25: 1345–1353.
Machala M, Vondrácek J, Bláha L, Ciganek M, Neca JV (2001) Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutat Res 497: 49–62.
Puglisi E, Murk AJ, van den Berg HJ, Grotenhuis T (2007) Extraction and bioanalysis of the ecotoxicologically relevant fraction of contaminants in sediments. Environ Toxicol Chem 26: 2122–2128.
Tolbert PE (1997) Oils and cancer. Cancer Causes Control 8: 386–405.
Van den Berg M, Birnbaum L, Brunstrom B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, van Leeuwen FX, Liem AK, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106: 775–792.
Vondrácek J, Machala M, Minksová K, Bláha L, Murk AJ, KozubÃk A, Hofmanová J, Hilscherová K, Ulrich R, Ciganek M, Neca J, Svrcková D, Holoubek I (2001) Monitoring river sediments contaminated predominantly with polyaromatic hydrocarbons by chemical and in vitro bioassay techniques. Environ Toxicol Chem 20: 1499–1506.
Yaffe D, Cohen Y, Arey J, Grosovsky AJ (2001) Multimedia analysis of PAHs and nitro-PAH daughter products in the Los Angeles Basin. Risk Anal 21: 275–294.
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van der Burg, B., Jonas, A., Sonneveld, E. (2010). Human Cell Line Based Assays for Toxic Poly Halogenated and Poly Aromatic Hydrocarbons in Oils and Lipids. In: Timmis, K.N. (eds) Handbook of Hydrocarbon and Lipid Microbiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77587-4_348
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DOI: https://doi.org/10.1007/978-3-540-77587-4_348
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-77584-3
Online ISBN: 978-3-540-77587-4
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