Skip to main content
SpringerLink
Log in

Squamous and Basal Cell Carcinoma of the Skin

  • Chapter
Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 1960 Accesses

Abstract

Basal and squamous cell carcinomas of the skin are the most common histologic types of skin cancer and the most common malignancies. They are significantly associated with ultraviolet light exposure, exposure to ionizing radiation, exposure to chemical carcinogens such as arsenic, chronic irritation, and gene mutations. Squamous cell carcinoma is also related to alterations in immune system. The incidence of non-melanoma skin cancer in the United States in 2007 was more than 1 million cases with an annual mortality of less than 2000. Approximately 20% of the American population will develop basal cell carcinoma and/or squamous cell carcinoma during their lifetime.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Avril MF, Auperin A, Margulis A et al. (1997) Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Br J Cancer 76:100–106

    PubMed  CAS  Google Scholar 

  • Boeta-Angeles L, Bennett RG (1998) Features associated with recurrence (basal cell carcinoma). In Miller SJ, Maloney ME (eds) Cutaneous oncology. Pathophysiology, diagnosis, and management. Blackwell Science, Malden, MA, p 646

    Google Scholar 

  • Berti JJ, Sharata HH (1999) Metastatic basal cell carcinoma to the lung. Cutis 63:165–166

    PubMed  CAS  Google Scholar 

  • Chao CK, Gerber RM, Perez CA (1995) Reirradiation of recurrent skin cancer of the face: a successful salvage modality. Cancer 75:2351–2355

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick PJ, Thompson GA, Easterbrook WM et al. (1984) Basal and squamous cell carcinoma of the eyelids and their treatment by radiotherapy. Int J Radiat Oncol Biol Phys 10:449–454

    PubMed  CAS  Google Scholar 

  • Freeman RG, Knox JM, Heaton CL (1964) The treatment of skin cancer: a statistical study of 1,314 skin tumors comparing results obtained with irradiation, surgery, and curettage followed by electrodesiccation. Cancer 17:535–538

    Article  PubMed  CAS  Google Scholar 

  • Friedman HI, Cooper PH, Wanebo HJ (1985) Prognostic and therapeutic use of microstaging of cutaneous squamous cell carcinoma of the trunk and extremities. Cancer 56:1099–1105

    Article  PubMed  CAS  Google Scholar 

  • Greene F, Page D, Fleming I et al. (2002) AJCC Cancer Staging Manual, 6th edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Gupta AK, Cardella CJ, Haberman HF (1986) Cutaneous malignant neoplasms in patients with renal transplants. Arch Dermatol 122:1288–1293

    Article  PubMed  CAS  Google Scholar 

  • Haas AF (1998) Features associated with metastasis (squamous cell carcinoma). In Miller SJ, Maloney ME (eds) Cutaneous oncology. Pathophysiology, diagnosis, and management. Blackwell Science, Malden, MA, p 500

    Google Scholar 

  • Immerman SC, Scanlon EF, Christ M et al. (1983) Recurrent squamous cell carcinoma of the skin. Cancer 51:1537–1540

    Article  PubMed  CAS  Google Scholar 

  • Kopf AW (1979) Computer analysis of 3531 basal cell carcinoma of the skin. J Dermatol 6:267–281

    PubMed  CAS  Google Scholar 

  • Locke J, Karimpour S, Young G et al. (2001) Radiotherapy for epithelial skin cancer. Int J Radiat Oncol Biol Phys 51:748–755

    PubMed  CAS  Google Scholar 

  • Lovett RD, Perez CA, Shapiro SJ et al. (1990) External irradiation of epithelial skin cancer. Int J Radiat Oncol Biol Phys 19:235–242

    PubMed  CAS  Google Scholar 

  • Mazeron JJ, Chassagne D, Crook J et al. (1988) Radiation therapy of carcinomas of the skin of the nose and nasal vestibule. A report of 1676 cases by the Groupe Europeen de Curietherapie. Radiother Oncol 13:165–173

    Article  PubMed  CAS  Google Scholar 

  • Mendenhall WM, Parsons JT, Mendenhall NP et al. (1987) T2–T4 carcinoma of the skin of the head and neck treated with radical irradiation. Int J Radiat Oncol Biol Phys 13:975–981

    PubMed  CAS  Google Scholar 

  • Mendenhall WM, Parsons JT, Mendenhall NP et al. (1989) Carcinoma of the skin of the head and neck with perineural invasion. Head Neck 11: 301–308

    Article  PubMed  CAS  Google Scholar 

  • McCord MW, Mendenhall WM, Parsons JT et al. (1999) Skin cancer of the head and neck with incidental microscopic perineural invasion. Int J Radiat Oncol Biol Phys 43:591–595

    PubMed  CAS  Google Scholar 

  • National Comprehensive Cancer Network (2008) Clinical practice guidelines in oncology: esophageal cancer. Version 2.2007. Available at http://www.nccn.org/professionals/physician_gls/PDF/esophageal.pdf.

    Google Scholar 

  • Robinson JK (1998) Follow-up and prevention. Follow-up and prevention (basal cell carcinoma). In Miller SJ, Maloney ME (eds) Cutaneous oncology. Pathophysiology, diagnosis, and management. Blackwell Science, Malden, MA, pp 695–698

    Google Scholar 

  • Rowe DE, Carroll RJ, Day CL (1989) Long-term recurrence rates in previously untreated basal cell carcinoma: implications for patient follow-up. J Dermatol Surg Ocol 15:315–328

    CAS  Google Scholar 

  • Rowe DE, Carroll RJ, Day CL (1992) Prognostic factors for local recurrence metastasis and survival rates in squamous cell carcinoma of the skin, ear and lip. Implications for treatment modality selection. J Am Acad Dermatol 26:976–990

    Article  PubMed  CAS  Google Scholar 

  • Shin DM, Maloney ME, Lippman SM (1998) Follow-up and prevention (squamous cell carcinoma). In Miller SJ, Maloney ME (eds) Cutaneous oncology. Pathophysiology, diagnosis, and management. Blackwell Science, Malden, MA, pp 565–570

    Google Scholar 

  • Terashi H, Kurata S, Tadokoro T et al. (1997) Perineural and neural involvement in skin cancers. Dermatol Surg 23:259–264

    Article  PubMed  CAS  Google Scholar 

  • Turesson I, Notter G (1984) The influence of fraction size in radiotherapy on the late normal tissue reaction-I: comparison of the effects of daily and once-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 10:593–598

    PubMed  CAS  Google Scholar 

  • Turesson I, Notter G (1984) The influence of fraction size in radiotherapy on the late normal tissue reaction-II: comparison of the effects of daily and twice-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 10:599–606

    PubMed  CAS  Google Scholar 

  • Turesson I, Notter G (1986) The predictive value of skin telangiectasia for late radiation effects in different normal tissues. Int J Radiat Oncol Biol Phys 12:603–609

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 W. Markham Street #771, Little Rock, AR, 72205, USA

    José A. Peñagarícano MD

  2. Winthrop P. Rockefeller Cancer Institute, 4301 W. Markham Street #623, Little Rock, AR, 72205, USA

    Vaneerat Ratanatharathorn MD

Authors
  1. José A. Peñagarícano MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vaneerat Ratanatharathorn MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology National University Cancer Institute of Singapore National University Health System, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  2. Department of Radiation Oncology, Cancer Hospital of Fudan University, 270 Dong An Road, Shanghai, 200232, P.R. China

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  3. College of Medicine, Drexel University, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Peñagarícano, J.A., Ratanatharathorn, V. (2008). Squamous and Basal Cell Carcinoma of the Skin. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77385-6_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77384-9

  • Online ISBN: 978-3-540-77385-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation