Abstract
Lung cancer is a significant cause of morbidity and mortality in the United States, with an estimated 173,000 new lung cancer cases and 156,300 deaths due to lung cancer in 2003 [1]. Eighty-five percent of these patients are diagnosed with non-small cell lung cancer (NSCLC), of which 15–20% will have early stage disease [2]. Treatment options for early stage NSCLC depend on patient factors, such as pulmonary reserve, to determine if a patient is a surgical candidate or not. Typically, standard “cut-off” medical guidelines for surgical resection of NSCLC include the following: baseline forced expiratory volume in 1 s (FEV1) < 40% of predicted, post-operative predicted FEV1 < 30%, severely reduced diffusion capacity, baseline hypoxemia and/or hypercapnia, and exercise oxygen consumption < 50% predicted. For the relatively healthy patient, the traditional treatment of choice for Stage I (T1–2, N0, M0) NSCLC usually consists of radical surgery (lobectomy, pneumonectomy) resulting in an approximate 60% to 80% 5-year overall survival [3]–[5].
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McGarry, R.C. (2007). Stereotactic Body Radiation Therapy in the Treatment of Early Stage Non-Small Cell Lung Cancer. In: Urschel, H.C., Kresl, J.J., Luketich, J.D., Papiez, L., Timmerman, R.D., Schulz, R.A. (eds) Treating Tumors that Move with Respiration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69886-9_13
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DOI: https://doi.org/10.1007/978-3-540-69886-9_13
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