Abstract
Constraint-induced movement therapy (CIMT) is a physical rehabilitation approach that can be used for children with unilateral cerebral palsy (CP). The focus is restraint of the less-affected hand along with intensive practice in daily activities to encourage the use of the more-affected hand with the aim to improve its function. It is one of the most investigated upper-extremity rehabilitation approaches in this population, and there is good evidence of efficacy. This chapter will describe important aspects to consider when implementing CIMT in clinical practice. Various models of the approach will be described, as well as the underlying theories for treatment and supporting evidence. CIMT as well as bimanual training and goal-directed training should be seen as an intensive complement to usual care and other specific needs for children with unilateral CP.
References
Aarts PB, Jongerius PH, Geerdink YA, Van Limbeek J, Geurts AC (2010) Effectiveness of modified constraint-induced movement therapy in children with unilateral spastic cerebral palsy: a randomized controlled trial. Neurorehabil Neural Repair 24:509–518
Arner M, Eliasson AC, Nicklasson S, Sommerstein K, Hagglund G (2008) Hand function in cerebral palsy. Report of 367 children in a population-based longitudinal health care program. J Hand Surg Am 33: 1337–1347
Basu AP (2014) Early intervention after perinatal stroke: opportunities and challenges. Dev Med Child Neurol 56:516–521
Charles JR, Gordon AM (2007) A repeated course of constraint-induced movement therapy results in further improvement. Dev Med Child Neurol 49:770–773
Charles JR, Wolf SL, Schneider JA, Gordon AM (2006) Efficacy of a child-friendly form of constraint-induced movement therapy in hemiplegic cerebral palsy: a randomized control trial. Dev Med Child Neurol 48: 635–642
Chen HC, Kang LJ, Chen CL, Lin KC, Chen FC, Wu KP (2016) Younger children with cerebral palsy respond better than older ones to therapist-based constraint-induced therapy at home on functional outcomes and motor control. Phys Occup Ther Pediatr 36:171–185
Chiu HC, Ada L (2016) Constraint-induced movement therapy improves upper limb activity and participation in hemiplegic cerebral palsy: a systematic review. J Physiother 62:130–137
Comans T, Mihala G, Sakzewski L, Boyd RN, Scuffham P (2017) The cost-effectiveness of a web-based multimodal therapy for unilateral cerebral palsy: the Mitii randomized controlled trial. Dev Med Child Neurol 59:756–761
De Brito Brandao M, Gordon AM, Mancini MC (2012) Functional impact of constraint therapy and bimanual training in children with cerebral palsy: a randomized controlled trial. Am J Occup Ther 66:672–681
Deluca SC, Trucks MR, Wallace DA, Ramey SL (2017) Practice-based evidence from a clinical cohort that received pediatric constraint- induced movement therapy. J Pediatr Rehabil Med 10:37–46
Deppe W, Thuemmler K, Fleischer J, Berger C, Meyer S, Wiedemann B (2013) Modified constraint-induced movement therapy versus intensive bimanual training for children with hemiplegia – a randomized controlled trial. Clin Rehabil 27:909–920
Diaz Heijtz R, Almeida R, Eliasson AC, Forssberg H (2018) Genetic variation in the dopamine system influences intervention outcome in children with cerebral palsy. EBioMedicine 28:162–167
Durand E, Plante P, Pelletier AA, Rondeau J, Simard F, Voisin J (2017) At-home and in-group delivery of constraint-induced movement therapy in children with hemiparesis: a systematic review. Ann Phys Rehabil Med 61:245–261
Eliasson AC, Holmefur M (2014) The influence of early modified constraint-induced movement therapy training on the longitudinal development of hand function in children with unilateral cerebral palsy. Dev Med Child Neurol 57:89–94
Eliasson AC, Krumlinde-Sundholm L, Shaw K, Wang C (2005) Effects of constraint-induced movement therapy in young children with hemiplegic cerebral palsy: an adapted model. Dev Med Child Neurol 47:266–275
Eliasson AC, Shaw K, Berg E, Krumlinde-Sundholm L (2011) An ecological approach of constraint induced movement therapy for 2-3-year-old children: a randomized control trial. Res Dev Disabil 32:2820–2828
Eliasson AC, Krumlinde-Sundholm L, Gordon AM, Feys H, Klingels K, Aarts PB, Rameckers E, Autti-Ramo I, Hoare B, European Network For Health Technology, A (2014) Guidelines for future research in constraint-induced movement therapy for children with unilateral cerebral palsy: an expert consensus. Dev Med Child Neurol 56:125–137
Eliasson AC, Nordstrand L, Ek L, Lennartsson F, Sjostrand L, Tedroff K, Krumlinde-Sundholm L (2018) The effectiveness of baby-cimt in infants younger than 12 months with clinical signs of unilateral-cerebral palsy; an explorative study with randomized design. Res Dev Disabil 72:191–201
Facchin P, Rosa-Rizzotto M, Visona Dalla Pozza L, Turconi AC, Pagliano E, Signorini S, Tornetta L, Trabacca A, Fedrizzi E (2011) Multisite trial comparing the efficacy of constraint-induced movement therapy with that of bimanual intensive training in children with hemiplegic cerebral palsy: postintervention results. Am J Phys Med Rehabil 90:539–553
Ferre CL, Gordon AM (2017) Coaction of individual and environmental factors: a review of intensive therapy paradigms for children with unilateral spastic cerebral palsy. Dev Med Child Neurol 59:1139–1145
Ferre CL, Brandao MB, Hung YC, Carmel JB, Gordon AM (2015) Feasibility of caregiver-directed home-based hand-arm bimanual intensive training: a brief report. Dev Neurorehabil 18:69–74
Ferre CL, Brandao M, Surana B, Dew AP, Moreau NG, Gordon AM (2017) Caregiver-directed home-based intensive bimanual training in young children with unilateral spastic cerebral palsy: a randomized trial. Dev Med Child Neurol 59:497–504
Geerdink Y, Aarts P, Van Der Burg J, Steenbergen B, Geurts A (2015) Intensive upper limb intervention with self-management training is feasible and promising for older children and adolescents with unilateral cerebral palsy. Res Dev Disabil 43–44:97–105
Gordon AM, Charles J, Wolf SL (2006) Efficacy of constraint-induced movement therapy on involved upper-extremity use in children with hemiplegic cerebral palsy is not age-dependent. Pediatrics 117:E363–E373
Gordon AM, Hung YC, Brandao M, Ferre CL, Kuo HC, Friel K, Petra E, Chinnan A, Charles JR (2011) Bimanual training and constraint-induced movement therapy in children with hemiplegic cerebral palsy: a randomized trial. Neurorehabil Neural Repair 25:692–702
Gupta D, Barachant A, Gordon AM, Ferre C, Kuo HC, Carmel JB, Friel KM (2017) Effect of sensory and motor connectivity on hand function in pediatric hemiplegia. Ann Neurol 82:766–780
Hanna SE, Law MC, Rosenbaum PL, King GA, Walter SD, Pollock N, Russell DJ (2003) Development of hand function among children with cerebral palsy: growth curve analysis for ages 16 to 70 months. Dev Med Child Neurol 45:448–455
Hoare B, Imms C, Villanueva E, Rawicki HB, Matyas T, Carey L (2013) Intensive therapy following upper limb botulinum toxin a injection in young children with unilateral cerebral palsy: a randomized trial. Dev Med Child Neurol 55:238–247
Holmefur M, Krumlinde-Sundholm L, Bergstrom J, Eliasson AC (2010) Longitudinal development of hand function in children with unilateral cerebral palsy. Dev Med Child Neurol 52:352–357
Holmstrom L, Vollmer B, Tedroff K, Islam M, Persson JK, Kits A, Forssberg H, Eliasson AC (2010) Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy. Dev Med Child Neurol 52:145–152
Hung YC, Casertano L, Hillman A, Gordon AM (2011) The effect of intensive bimanual training on coordination of the hands in children with congenital hemiplegia. Res Dev Disabil 32:2724–2731
Islam M, Nordstrand L, Holmstrom L, Kits A, Forssberg H, Eliasson AC (2014) Is outcome of constraint-induced movement therapy in unilateral cerebral palsy dependent on corticomotor projection pattern and brain lesion characteristics? Dev Med Child Neurol 56:252–258
James S, Ziviani J, Ware RS, Boyd RN (2015) Randomized controlled trial of web-based multimodal therapy for unilateral cerebral palsy to improve occupational performance. Dev Med Child Neurol 57:530–538
Kirton A, Andersen J, Herrero M, Nettel-Aguirre A, Carsolio L, Damji O, Keess J, Mineyko A, Hodge J, Hill MD (2016) Brain stimulation and constraint for perinatal stroke hemiparesis: the plastic champs trial. Neurology 86:1659–1667
Klingels K, Demeyere I, Jaspers E, De Cock P, Molenaers G, Boyd R, Feys H (2012) Upper limb impairments and their impact on activity measures in children with unilateral cerebral palsy. Eur J Paediatr Neurol 16:475–484
Krumlinde-Sundholm L, Ek L, Sicola E, Sjostrand L, Guzzetta A, Sgandurra G, Cioni G, Eliasson AC (2017) Development of the hand assessment for infants: evidence of internal scale validity. Dev Med Child Neurol 59:1276–1283
Kuhnke N, Juenger H, Walther M, Berweck S, Mall V, Staudt M (2008) Do patients with congenital hemiparesis and ipsilateral corticospinal projections respond differently to constraint-induced movement therapy? Dev Med Child Neurol 50:898–903
Martin JH, Chakrabarty S, Friel KM (2011) Harnessing activity-dependent plasticity to repair the damaged corticospinal tract in an animal model of cerebral palsy. Dev Med Child Neurol 53:9–13
Nordstrand L, Eliasson AC (2013) Six years after a modified constraint induced movement therapy (cimt) program–what happens when the children have become young adults? Phys Occup Ther Pediatr 33:163–169
Nordstrand L, Eliasson AC, Holmefur M (2016) Longitudinal development of hand function in children with unilateral spastic cerebral palsy aged 18 months to 12 years. Dev Med Child Neurol 58:1042–1048
Novak I, Mcintyre S, Morgan C, Campbell L, Dark L, Morton N, Stumbles E, Wilson SA, Goldsmith S (2013) A systematic review of interventions for children with cerebral palsy: state of the evidence. Dev Med Child Neurol 55:885–910
Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom-Hernandez J, Cioni G, Damiano D, Darrah J, Eliasson AC, De Vries LS, Einspieler C, Fahey M, Fehlings D, Ferriero DM, Fetters L, Fiori S, Forssberg H, Gordon AM, Greaves S, Guzzetta A, Hadders-Algra M, Harbourne R, Kakooza-Mwesige A, Karlsson P, Krumlinde-Sundholm L, Latal B, Loughran-Fowlds A, Maitre N, Mcintyre S, Noritz G, Pennington L, Romeo DM, Shepherd R, Spittle AJ, Thornton M, Valentine J, Walker K, White R, Badawi N (2017) Early, accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment. JAMA Pediatr 171(9):897–907
Rostami HR, Malamiri RA (2012) Effect of treatment environment on modified constraint-induced movement therapy results in children with spastic hemiplegic cerebral palsy: a randomized controlled trial. Disabil Rehabil 34:40–44
Ryll UC, Bastiaenen CHG, Eliasson A-C (2017) Assisting hand assessment and children’s hand-use experience questionnaire –observed versus perceived bimanual performance in children with unilateral cerebral palsy. Phys Occup Ther Pediatr 37:199–209
Sakzewski L, Sicola E, Verhage CH, Sgandurra G, Eliasson AC (2018) Development of hand function during the first year of life in children with unilateral cerebral palsy. Dev Med Child Neurol. https://doi.org/10.1111/dmcn.14091
Sakzewski L, Ziviani J, Abbott D, Macdonell R, Jackson G, Boyd R (2011) Randomized trial of constraint-induced movement therapy and bimanual training on activity outcomes for children with congenital hemiplegia. Dev Med Child Neurol 53:313–320
Sakzewski L, Gordon A, Eliasson AC (2014a) The state of the evidence for intensive upper limb therapy approaches for children with unilateral cerebral palsy. J Child Neurol 29:1077–1090
Sakzewski L, Provan K, Ziviani J, Boyd RN (2014b) Comparison of dosage of intensive upper limb therapy for children with unilateral cerebral palsy: how big should the therapy pill be? Res Dev Disabil 37c:9–16
Sakzewski L, Ziviani J, Boyd RN (2014c) Efficacy of upper limb therapies for unilateral cerebral palsy: a meta-analysis. Pediatrics 133:E175–E204
Sakzewski L, Miller L, Ziviani J, Abbott DF, Rose S, Macdonell RA, Boyd RN (2015) Randomized comparison trial of density and context of upper limb intensive group versus individualized occupational therapy for children with unilateral cerebral palsy. Dev Med Child Neurol 57:539–547
Shikako-Thomas K, Fehlings D, Germain M, Gordon AM, Maynard D, Majnemer A (2017) Current practice “constraints” in the uptake and use of intensive upper extremity training: a Canadian perspective. Phys Occup Ther Pediatr 38:143
Smorenburg AR, Gordon AM, Kuo HC, Ferre CL, Brandao M, Bleyenheuft Y, Carmel JB, Friel KM (2017) Does corticospinal tract connectivity influence the response to intensive bimanual therapy in children with unilateral cerebral palsy? Neurorehabil Neural Repair 31:250–260
Staudt M, Gordon AM (2016) Combining rtms and cimt: a “one-size-fits-all” therapy for congenital hemiparesis? Neurology 86:1652–1654
Staudt M, Gerloff C, Grodd W, Holthausen H, Niemann G, Krageloh-Mann I (2004) Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol 56:854–863
Taub E, Miller NE, Novack TA, Cook EW, Iii F, C W, Nepomuceno CS, Connell JS, Crago JE (1993) Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 74:347–354
Taub E, Uswatte G, Pidikiti R (1999) Constraint-induced movement therapy: a new family of techniques with broad application to physical rehabilitation–a clinical review [see comments]. [Review] [91 refs]. J Rehabil Res Dev 36:237–251
Tervahauta MH, Girolami GL, Oberg GK (2017) Efficacy of constraint-induced movement therapy compared with bimanual intensive training in children with unilateral cerebral palsy: a systematic review. Clin Rehabil 31:1445–1456
Valvano J (2004) Activity-focused motor interventions for children with neurological conditions. Phys Occup Ther Pediatr 24:79–107
Winstein CJ, Miller JP, Blanton S, Taub E, Uswatte G, Morris D, Nichols D, Wolf S (2003) Methods for a multisite randomized trial to investigate the effect of constraint-induced movement therapy in improving upper extremity function among adults recovering from a cerebrovascular stroke. Neurorehabil Neural Repair 17:137–152
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Eliasson, AC., Gordon, A.M. (2020). Constraint-Induced Movement Therapy for Children and Youth with Hemiplegic/Unilateral Cerebral Palsy. In: Miller, F., Bachrach, S., Lennon, N., O'Neil, M.E. (eds) Cerebral Palsy. Springer, Cham. https://doi.org/10.1007/978-3-319-74558-9_175
Download citation
DOI: https://doi.org/10.1007/978-3-319-74558-9_175
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-74557-2
Online ISBN: 978-3-319-74558-9
eBook Packages: MedicineReference Module Medicine