Synonyms
Localized fibrous mesothelioma; Localized fibrous tumor; Pleural fibroma; SFTP. Other names used in the past: Localized pleural mesothelioma; Solitary fibrous mesothelioma; Submesothelial fibroma; Subserosal fibroma
Definition
Solitary fibrous tumor of the pleura (SFTP) is an uncommon neoplasm, often with an indolent clinical course. The origin of this tumor was a subject of controversy for many years. Initially, these localized pleural tumors were considered to have a mesothelial origin, similar to the diffuse pleural mesothelioma; therefore, it was called “localized mesothelioma.” However, in more recent years, advances in electron microscopy and immunohistochemistry have demonstrated that SFTP arises from the submesothelial mesenchymal layer, differentiating them from pleural mesotheliomas. SFTP is not associated with asbestos exposure or with any other environmental agent, as opposed to pleural mesotheliomas.
SFTP has benign and malignant variants, determined by...
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References and Further Reading
Cardillo, G., Lococo, F., Carleo, F., et al. (2012). Solitary fibrous tumors of the pleura. Current Opinion in Pulmonary Medicine, 18, 339–346.
de Perrot, M., Fischer, S., Brundler, M. A., et al. (2002). Solitary fibrous tumors of the pleura. Annals of Thoracic Surgery, 74, 285–293.
England, D. M., Hochholzer, L., & McCarthy, M. J. (1989). Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. American Journal of Surgical Pathology, 13(8), 640–658.
Harrison-Phipps, K. M., Nichols, F. C., Schleck, C. D., et al. (2009). Solitary fibrous tumor of the pleura: Results of surgical treatment and long-term prognosis. Journal of Thoracic and Cardiovascular Surgery, 138(1), 19–25.
Okike, N., Bernatz, P. E., & Woolner, L. B. (1978). Localized mesothelioma of the pleura, benign and malignant variants. Journal of Thoracic and Cardiovascular Surgery, 75, 363–372.
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Clement, C., Allen, T.C. (2018). Solitary Fibrous Tumor, Pleural. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_390
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DOI: https://doi.org/10.1007/978-3-319-66796-6_390
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