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Retinal Pigment Epithelial Detachment in Polypoidal Choroidal Vasculopathy

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Abstract

Formerly described mostly in Asian populations, polypoidal lesions are nowadays detected at a much higher rate also in Caucasians. With up to 17% of nAMD caucasian patients, polypoidal choroidal vasculopathy (PCV) is not a rare disease anymore. Active PCV lesions may be the reason for a developing pigment epithelial detachment (PED) and, as a consequence, these PEDs can be influenced by treating the underlying PCV lesions with laser photocoagulation, photodynamic therapy (PDT), and/or intravitreal anti-VEGF (vascular endothelial growth factor) injections.

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References

  1. Stern RM, Zakov AN, Zegarra N, et al. Multiple recurrent serosanguineous retinal pigment epithelial detachments in black women. Am J Ophthalmol. 1985;10:560–9.

    Article  Google Scholar 

  2. Kleiner RC, Brucker AJ, Johnston RL. The posterior uveal bleeding syndrome. Retina. 1990;10:9–17.

    Article  CAS  PubMed  Google Scholar 

  3. Gass JDM. Diseases causing choroidal exsudative and hemorrhagic localized (disciform) detachment of the retina and retinal pigment epithelium. In:Stereoscopic atlas of macular diseases, vol. 1. 4th ed. London: Mosby; 1997. p. 250–1.

    Google Scholar 

  4. Yannuzzi LA, Sorenson J, Spaide RF, et al. Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina. 1990;10:1–8.

    Article  CAS  PubMed  Google Scholar 

  5. Spaide RF, Yannuzzi LA, Slakter JS, et al. Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina. 1995;15:100–10.

    Google Scholar 

  6. Yannuzzi LA, Ciardella A, Spaide RF, et al. The expanding clinical spectrum of idiopathic polypoidal vasculopathy. Arch Ophthalmol. 1997;115:478–85.

    Article  CAS  PubMed  Google Scholar 

  7. Imamura Y, Engelbert M, Iida T, et al. Polypoidal choroidal vasculopathy. Surv Ophthalmol. 2010;55:501–15.

    Google Scholar 

  8. Ciardella AP, Donsoff IM, Huang SJ, et al. Polypoidal choroidal vasculopathy. Surv Ophthalmol. 2004;49:25–37.

    Article  PubMed  Google Scholar 

  9. Hatz K, Prünte C. Polypoidal choroidal vasculopythy in Caucasian patients with presumed neovascular age-related macular degneration and poor ranibizumab response. Br J Ophthalmol. 2014;98:188–94.

    Article  PubMed  Google Scholar 

  10. Cho JH, Ryod NK, Cho KH, et al. Incidence rate of massive submacular hemorrhage and its risk factors in polypidal vasculopathy. In: Abstract, ARVO 2016; 2016.

    Google Scholar 

  11. Honda S, Matsumiya W, Negi A. Polypoidal choroidal vasculopathy: clinical features and genetic predisposition. Ophthalmologica. 2014;231:59–74.

    Article  PubMed  Google Scholar 

  12. Iwama D, Tsujikawa A, Sasahara M, et al. Polypoidal choroidal vasculopathy with drusen. Jpn J Ophthalmol. 2008;52:116–21.

    Article  PubMed  Google Scholar 

  13. Kuroiwa S, Tateiwa H, Hisatomi T, et al. Pathologic features of surgically excised polypoidal choroidal vasculopathy membranes. Clin Exp Ophthalmol. 2004;32:297–302.

    Article  PubMed  Google Scholar 

  14. Yuzawa M, Mori R, Kawamura A. The origins of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2005;89:602–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nakajima M, Yuzawa M, Shimada H, et al. Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2004;48:249–55.

    Article  PubMed  Google Scholar 

  16. Nakashizuka H, Mitsumata M, Okisaka S, et al. Clinicopathologic findings in polypoidal choroidal vasculopathy. IOVS. 2008;49:4729–37.

    Google Scholar 

  17. Tan CS, Ngo WK. Predictive features of polypoidal choroidal vasculopathy detected using fluorescein angiography. In: Abstract from ASCRS, ASOA Sympoium and Congress; 2015 Apr 17–21; San Diego.

    Google Scholar 

  18. Coscas G, Yamashiro K, Coscas F, et al. Comparison of exudative age-related macular degeneration subtypes in Japanese and French patients: Mulicenter diagnosis with multimodal imaging. Am J Ophthalmol. 2014;158:309–18.

    Article  PubMed  Google Scholar 

  19. Tan CS, Ngo WK, Chen JP, et al. EVEREST study report 2: imaging and grading protocol, and baseline characteristics of a randomised controlled trial of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2015;99(5):624–8. doi:10.1136/bjophthalmol-2014-305674.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Byeon SH, Lee SC, HS O, et al. Incidence and clinical patterns of polypoidal choroidal vasculopathy in Korean patients. Jpn J Ophthalmol. 2008;52:57–62.

    Google Scholar 

  21. Tsujikawa A, Sasahara M, Otani A, et al. Pigment epithelial Detchment in polypoidal choroidal vasculopathy. Am J Ophthalmol. 2007;143:102–11.

    Article  PubMed  Google Scholar 

  22. Shaimov T, Panova I. Diagnostic capabilities of polypoidal choroidal vasculopathy in the absence of indocyanine green angiography. Poster presented at 14th EURETINA Congress; 2014; London.

    Google Scholar 

  23. de Salvo G, Vaz-Pereira S, Keane PA, et al. Sensitivity and specificity of spectral-domain optical coherence tomography in detecting idiopathic polypoidal choroidal vasculopathy. Am J Ophthalmol. 2014;158:1228–38.

    Article  PubMed  Google Scholar 

  24. Lim LW, Tan CS, Chay IW, et al. Optical coherence tomography angiography features of polypoidal vasculopathy and its correlation with indocyanine green angiography. In: Abstract, ARVO 2016; 2016.

    Google Scholar 

  25. Uyama M, Wada M, Nagai Y, et al. Polypoidal choroidal vasculopythy: natural history. Am J Ophthalmol. 2002;133:639–48.

    Article  PubMed  Google Scholar 

  26. Sho K, Takahashi K, Yamada H, et al. Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics. Arch Ophthalmol. 2003;121:1392–6.

    Article  PubMed  Google Scholar 

  27. Cheung CMG, Yang E, Lee WK, et al. The natural history of polypoidal choroidal vasculopathy: a multi-center series of untreated Asian patients. Graefes Arch Clin Exp Ophthalmol. 2015;253:2075–85.

    Article  PubMed  Google Scholar 

  28. Yuzawa M, Mori R, Haruyama M. A study of laser photocoagulation for polypoidal vasculopathy. Jpn J Ophthalmol. 2003;47:379–84.

    Article  PubMed  Google Scholar 

  29. Shiraga F, Shirakata Y, Shiragami C, et al. Laser photocoagulation sparing the Papillomacular bundle for peripapillary polypoidal choroidal vasculopathy lesions. Austin J Clin Ophthalmol. 2014;1:1015–3.

    Google Scholar 

  30. Wong CW, Wong TY, Cheung CMG. Polypoidal choroidal vasculopathy in Asians. J Clin Med. 2015b;4:782–821.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Ueno C, Gomi F, Sawa M, et al. Correlation of indocyanine green angiography and optical coherence tomography findings after intravitreal ranibizumab for polypoidal choroidal vasculopathy. Retina. 2012;32:2006–13.

    Article  CAS  PubMed  Google Scholar 

  32. Kang HM, Koh HJ. Long-term visual outcome and prognostic factors after intravitreal ranibizumab injections for polypoidal choroidal vasculoparthy. Am J Ophthalmol. 2013;156:652–60.

    Article  PubMed  Google Scholar 

  33. Kokame GT, Yeung L, Teramoto K, et al. Polypoidal choroidal vasculopathy, exudation and hemorrhage: results of monthly ranibizumab therapy at one year. Ophthalmologica. 2014;231:94–102.

    Article  CAS  PubMed  Google Scholar 

  34. Kokame GT. Prospective evaluation of subretinal vessel location in polypoidal choroidal vasculopathy and response of hemorrhagic and exudative PCV to high-dose Antiangiogenic therapy. Trans Am Ophthalmol Soc. 2014;112:74–93.

    PubMed  PubMed Central  Google Scholar 

  35. Oishi A, Kojima KH, Mandai M, et al. Comparison of the effect of ranibizumab and verteporfin for polypoidal choroidal vasculopathy: 12-month LAPTOP study results. Am J Opthalmol. 2014;156:644–51.

    Article  Google Scholar 

  36. Inoue M, Arakawa A, Yamane S. Short-term efficacy of intravitreal aflibercept in treatment-naïve patients with polypoidal choroidal vasculopathy. Retina. 2014;34:2178–84.

    Article  CAS  PubMed  Google Scholar 

  37. Hosokawa M, Shiraga F, Yamashita A, et al. Six-month results of intravitreal aflibercept injections for patients with polypoidal choroidal vasculopathy. Br J Ophthalmol. 2015; doi:10.1136/bjophthalmol-2014-305275.

    PubMed  Google Scholar 

  38. Kang HM, Kim YM, Koh HJ. Five-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2013;155:438–47.

    Article  PubMed  Google Scholar 

  39. Wong IY, Shi X, Gangwani R, et al. 1-year results of combined half-dose photodynamic therapy and ranibizumab for polypoidal choroidal vasculopathy. BMC Ophthalmol. 2015;15:66–72.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Koh AHC, Lee WK, Chen LJ, et al. EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy. Retina. 2012;32:1453–64.

    Article  CAS  PubMed  Google Scholar 

  41. Koh AHC, Chen LJ, Chen SJ, et al. Polypoidal vasculopathy: evidence-based guidelines for clinical diagnosis and treatment. Retina. 2013;33:686–716.

    Article  PubMed  Google Scholar 

  42. Tan CS, Lim LW, Ngo WK. Comparison of treatment outcomes among subtypes of polypoidal choroidal vasculopathy in a multicenter randomized controlled study (EVEREST study). In: Abstract, ARVO 2016; 2016.

    Google Scholar 

  43. Lee SJ, Pak KY, Byon IS. Treat-and-extend regimen using ranibizumab for polypoidal choroidal vasculopathy: one year results. In: Abstract, ARVO 2016; 2016.

    Google Scholar 

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Correspondence to Werner Inhoffen .

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Inhoffen, W. (2017). Retinal Pigment Epithelial Detachment in Polypoidal Choroidal Vasculopathy. In: Gamulescu, M., Helbig, H., Wachtlin, J. (eds) Retinal Pigment Epithelial Detachment. Springer, Cham. https://doi.org/10.1007/978-3-319-56133-2_6

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  • DOI: https://doi.org/10.1007/978-3-319-56133-2_6

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