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An Overview of the Endovascular Treatment of Intracranial Aneurysms

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Textbook of Catheter-Based Cardiovascular Interventions

Abstract

Endovascular treatment has become the mainstay of treatment for most ruptured and many unruptured cerebral aneurysms. This chapter first discusses key evidence for this development and presents the equipment and procedures for standard unassisted coiling of cerebral aneurysms. Major complications and management/preventive measures are reviewed together with adjunctive issues such as anaesthesia, anticoagulation and post-procedural care. Then, simpler assist techniques for aneurysm coiling (balloon remodelling and the double microcatheter approach) are described. The second section of the chapter covers reconstructive approaches to the treatment of complex aneurysms. Indications for the use of devices such as stents, flow diverters, other neck bridge devices and intrasaccular flow disruption devices are discussed, and an overview of the evidence for their use provided. Practical technical considerations specific to the use of these devices are presented and complications discussed for each class of device. The final section of the chapter discusses deconstructive and combined endovascular therapy options, along with necessary occlusion testing. The procedural and technical aspects of parent vessel occlusion are presented along with key management tips. A brief overview of combined approaches is given at the end of the chapter. Illustrative figures are provided throughout the text along with key references.

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Notes

  1. 1.

    Roadmaps (trace subtract fluoroscopy) are produced when a peak bolus is automatically traced over the area in view when contrast is administered under fluoroscopy. The resulting image shows a vascular structure as if it were completely filled: the reference image or “roadmap”. Subsequent fluoroscopy shows the progress of the intervention over this reference image. The roadmap image can be faded in/out for enhanced viewing. Run exposure can be performed without losing the roadmap image, saving contrast and X-ray dose. In addition, the subtracted fluoroscopy can be re-masked to compensate for movement.

  2. 2.

    SmartMask™ (or equivalent) simplifies roadmapping procedures by overlaying fluoroscopy with a selected reference digital subtraction angiography image on the live monitor. The reference and fluoroscopy images can be adjusted to preference.

References and Recommended Further Reading

  1. Abud DG, Spelle L, Piotin M, et al. Venous phase timing during balloon test occlusion as a criterion for permanent internal carotid artery sacrifice. Am J Neuroradiol. 2005;26:2602–9.

    PubMed  Google Scholar 

  2. Aletich VA, Debrun GM, Monsein LH, et al. Giant serpentine aneurysms: a review and presentation of five cases. Am J Neuroradiol. 1995;16:1061–72.

    PubMed  CAS  Google Scholar 

  3. Arat A, Islak C, Saatci I, et al. Endovascular parent artery occlusion in large-giant or fusiform distal posterior cerebral artery aneurysms. Neuroradiology. 2002;44:700–5.

    Article  PubMed  Google Scholar 

  4. Barker DW, Jungreis CA, Horton JA, et al. Balloon test occlusion of the internal carotid artery: change in stump pressure over 15 minutes and its correlation with xenon CT cerebral blood flow. Am J Neuroradiol. 1993;14:587–90.

    PubMed  CAS  Google Scholar 

  5. Biondi A, Jean B, Vivas E, et al. Giant and large peripheral cerebral aneurysms: etiopathologic considerations, endovascular treatment, and long-term follow-up. Am J Neuroradiol. 2006;27:1685–92.

    PubMed  CAS  Google Scholar 

  6. Briganti F, Cirillo S, Caranci F, et al. Development of “de novo” aneurysms following endovascular procedures. Neuroradiology. 2002;44:604–9.

    Article  CAS  PubMed  Google Scholar 

  7. Brinjikji W, Cloft HJ, Kallmes DF. Difficult aneurysms for endovascular treatment: overwide or undertall? Am J Neuroradiol. 2009;30:1513–7.

    Article  CAS  PubMed  Google Scholar 

  8. Brinjikji W, McDonald JS, Kallmes DF, Cloft HJ. Rescue treatment of thromboembolic complications during endovascular treatment of cerebral aneurysms. Stroke. 2013;44:1343–7.

    Article  CAS  PubMed  Google Scholar 

  9. Brinjikji W, Murad MH, Lanzino G, et al. Endovascular treatment of intracranial aneurysms with flow diverters: a meta-analysis. Stroke. 2013;44:442–7.

    Article  PubMed  Google Scholar 

  10. Brunberg JA, Frey KA, Horton JA, et al. Positron emission tomography determination of cerebral blood flow during test occlusion of the internal carotid artery. Am J Neuroradiol. 1994;15:725–32.

    PubMed  CAS  Google Scholar 

  11. Chalouhi N, Tjoumakaris S, Gonzalez LF, et al. Coiling of large and giant aneurysms: complications and long-term results of 334 cases. Am J Neuroradiol. 2014;35:546–52.

    Article  CAS  PubMed  Google Scholar 

  12. Chalouhi N, Starke RM, Koltz MT, et al. Stent-assisted coiling versus balloon remodelling of wide-neck aneurysms: comparison of angiographic outcomes, Am J Neuroradiol. 2013;34:1987–1992.

    Article  CAS  PubMed  Google Scholar 

  13. Chalouhi N, Jabbour P, Singhal S, et al. Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 cases. Stroke. 2013;44:1348–53.

    Article  PubMed  Google Scholar 

  14. Chapot R, Houdart E, Saint-Maurice JP, et al. Endovascular treatment of cerebral mycotic aneurysms. Radiology. 2002;222:389–96.

    Article  PubMed  Google Scholar 

  15. Chapot R. T stenting. Personal communication at Brainstorm Neurointerventional Course, Edinburgh; 2013.

    Google Scholar 

  16. Connolly ES, Rabinstein AA, Carphuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage. Stroke. 2012;43:1711–37.

    Article  PubMed  Google Scholar 

  17. Connors JJ. Temporary test occlusion of the internal carotid artery. In: Connors JJ, Wojak JC, editors. Interventional neuroradiology. Strategies and practical techniques. Philadelphia: Saunders; 1999. p. 377–90.

    Google Scholar 

  18. Connors JJ. Permanent occlusion of the internal carotid artery. In: Connors JJ, Wojak JC, editors. Interventional neuroradiology. Strategies and practical techniques. Philadelphia: Saunders; 1999. p. 390–408.

    Google Scholar 

  19. Connors JJ, Wojak J. Rupture of a vessel, aneurysm or arteriovenous malformation. In: Connors JJ, Wojak JC, editors. Interventional neuroradiology. Strategies and practical techniques. Philadelphia: Saunders; 1999. p. 775–81.

    Google Scholar 

  20. Cooper BB. Lectures on the principles and practice of surgery. 2nd ed. Philadelphia: Blanchard and Lee; 1852.

    Google Scholar 

  21. Cruz JP, Chow M, O'Kelly C, et al. Delayed ipsilateral parenchymal hemorrhage following flow diversion for the treatment of anterior circulation aneurysms. Am J Neuroradiol. 2012;33:603–8.

    Article  CAS  PubMed  Google Scholar 

  22. Currie S, Mankad K, Goddard A. Endovascular treatment of intracranial aneurysms: review of current practice. Postgrad Med J. 2011;87:1041–50.

    Article  Google Scholar 

  23. de Gast AN, Sprengers ME, van Rooij WJ, et al. Long term 3T-MRA follow-up after therapeutic occlusion of the internal carotid artery to detect possible de novo aneurysm formation. Am J Neuroradiol. 2007;28:508–10.

    PubMed  Google Scholar 

  24. Drake CG, Peerless SJ. Giant fusiform intracranial aneurysms: review of 120 patients treated surgically from 1965 to 1992. J Neurosurg. 1997;87:141–62.

    Article  CAS  PubMed  Google Scholar 

  25. Dyste GW, Beck DW. De novo aneurysm formation following carotid ligation: case report and review of the literature. Neurosurgery. 1989;24:88–92.

    Article  CAS  PubMed  Google Scholar 

  26. Eckard DA, O’Boynick PL, McPherson C, et al. Coil occlusion of the parent artery for treatment of symptomatic peripheral intracranial aneurysms. Am J Neuroradiol. 2000;21:137–42.

    PubMed  CAS  Google Scholar 

  27. Farouque HM, Tremmel JA, Raissi Shabari F, et al. Risk factors for the development of retroperitoneal hematoma after percutaneous coronary intervention in the era of glycoprotein IIb/IIIa inhibitors and vascular closure devices. J Am Coll Cardiol. 2005;45:363–8.

    Article  CAS  PubMed  Google Scholar 

  28. Fields JD, Brambrink L, Dogan A, et al. Stent assisted coil embolization of unruptured middle cerebral artery aneurysms. J Neurointerv Surg. 2013;5:15–9.

    Article  PubMed  Google Scholar 

  29. Fiorella D, Woo HH. Balloon assisted treatment of intracranial aneurysms: the conglomerate coil mass technique. J Neurointerv Surg. 2009;1:121–31.

    Article  CAS  PubMed  Google Scholar 

  30. Fischer S, Vajda Z, Aguilar Perez M, et al. Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissections. Neuroradiology. 2012;54:369–82.

    Article  PubMed  Google Scholar 

  31. Fox AJ, Vinuela F, Pelz DM, et al. Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms. J Neurosurgery. 1987;66:40–6.

    Article  CAS  Google Scholar 

  32. Gabriel CM, Stevens JC, Bremner F, et al. Optic chiasm enhancement associated with giant aneurysm and yttrium treated pituitary adenoma. J Neurol Neurosurg Psychiatry. 2004;75:1343–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Guo J, Shi K, Yang H, et al. Endothelin receptor antagonists for subarachnoid haemorrhage. Cochrane Database Syst Rev. 2012. https://doi.org/10.1002/14651858.CD008354.pub2.

  34. Halbach VV, Higashida RT, Dowd CF, et al. Endovascular treatment of vertebral artery dissections and pseudoaneurysms. J Neurosurg. 1993;79:183–1.

    Article  CAS  PubMed  Google Scholar 

  35. Hammoud D, Gailloud P, Olivi A, Murphy KJ. Acute vasogenic edema induced by thrombosis of a giant intracranial aneurysm: a cause of pseudostroke after therapeutic occlusion of the parent vessel. Am J Neuroradiol. 2003;24:1237–9.

    PubMed  Google Scholar 

  36. Huang QH, Wu YF, Xu Y, Hong B, et al. Vascular geometry change because of endovascular stent placement for anterior communicating artery aneurysms. Am J Neuroradiol. 2011;32:1721–5.

    Article  PubMed  Google Scholar 

  37. Ihn YK, Kim DI, Kim BS, Lee JM. Utility of catheter-assisted Guglielmi detachable coiling in the treatment of wide-necked aneurysms. Acat Neurochir. 2006;148:1045–52.

    Article  CAS  Google Scholar 

  38. International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms-risk of rupture and risks of surgical intervention. N Engl J Med. 1998;339:1725–33.

    Article  Google Scholar 

  39. International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362:103–10.

    Article  Google Scholar 

  40. Jain R, Hoeffner EG, Deveikis JP, et al. Carotid perfusion CT with balloon occlusion and acetazolamide challenge test: feasibility. Radiology. 2004;231:906–13.

    Article  PubMed  Google Scholar 

  41. Johnston SC, Higashida RT, Barrow DL, et al. Recommendations for the endovascular treatment of aneurysms. Stroke. 2002;33:2536–44.

    Article  PubMed  Google Scholar 

  42. Johnston SC, Zhao S, Dudley RA, et al. Treatment of unruptured cerebral aneurysms in California. Stroke. 2001;32:597–605.

    Article  CAS  PubMed  Google Scholar 

  43. Kale BD, Cloft HJ, Lanzino G, et al. A qualitative, systematic review of the literature on stent assisted coiling in ruptured aneurysms. Am J Neuroradiol. 2011;32:1232–6.

    Article  Google Scholar 

  44. Kirkpatrick PJ, Turner CL, Smith C, et al. Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial. Lancet Neurol. 2014;13:666–75.

    Article  CAS  PubMed  Google Scholar 

  45. Kulcsár Z, Houdart E, Bonafé A, et al. Intra-aneurysmal thrombosis as a possible cause of delayed aneurysm rupture after flow-diversion treatment. Am J Neuroradiol. 2011;32:20–5.

    Article  PubMed  Google Scholar 

  46. Lanzer P. Mastering endovascular techniques: a guide to excellence. Philadelphia: Lippincott Williams & Wilkins; 2007.

    Google Scholar 

  47. Li MH, Gao BL, Fang C, Cheng YS, Li YD, Wang J, Xu GP. Prevention and management of intraprocedural rupture of intracranial aneurysm with detachable coils during embolization. Neuroradiology. 2006;48:907–15.

    Article  PubMed  Google Scholar 

  48. Malek AM, Halbach VV, Phatouros CC, et al. Balloon-assist technique for endovascular coil embolization of geometrically difficult intracranial aneurysms. Neurosurgery. 2000;46:1397–406.

    Article  CAS  PubMed  Google Scholar 

  49. Masaryk TJ, Perl J, Wallace RC, et al. Detachable balloon embolization: concomitant use of a second safety balloon. Am J Neuroradiol. 1999;20:1103–6.

    PubMed  CAS  Google Scholar 

  50. Hitter BO. Neuropsychological sequelae of subarachnoid hemorrhage and its treatment. New York: Springer; 2001.

    Google Scholar 

  51. Medel R, Crowley RW, Hamilton DK, Dumont AS. Endovascular obliteration of an intracranial pseudoaneurysm: the utility of Onyx. J Neurosurg Pediatrics. 2009;4:445–8.

    Article  Google Scholar 

  52. Mees SMD, Algra A, Vandertop WP, et al. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet. 2012;380:44–9.

    Article  CAS  PubMed Central  Google Scholar 

  53. Molyneux AJ, Kerr RS, Yu LM, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005;366:809–17.

    Article  PubMed  Google Scholar 

  54. Molyneux AJ, Kerr RS, Birks J, et al. Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up. Lancet Neurol. 2009;8:427–33.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Molyneux AJ, Birks J, Clarke A, et al. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT). Lancet. 2015;385:691–7.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Molyneux AJ, Clarke A, Sneade M, et al. Cerecyte coil trial: angiographic outcomes of a prospective randomized trial comparing endovascular coiling of cerebral aneurysms with either cerecyte or bare platinum coils. Stroke. 2012;43:2544–50.

    Article  CAS  PubMed  Google Scholar 

  57. Moody EB, Dawson RP, Sandler MP. 99mTc-HMPAO SPECT imaging in interventional neuroradiology: validation of balloon test occlusion. Am J Neuroradiol. 1991;12:1043–4.

    PubMed  CAS  Google Scholar 

  58. Morris P. Practical neuroangiography. 1st ed. Baltimore: Lippincott Williams & Wilkins; 1997.

    Google Scholar 

  59. National Patient Safety Agency. Patient safety update. WHO surgical safety checklist. London: NPSA; 2009.

    Google Scholar 

  60. Naggara ON, White PM, Guilbert F, et al. Endovascular treatment of intracranial unruptured aneurysms: systematic review and meta-analysis of the literature on safety and efficacy. Radiology. 2010;256:887–97.

    Article  PubMed  Google Scholar 

  61. Nelson PK, Levy DI. Balloon-assisted coil embolization of wide-necked aneurysms of the internal carotid artery: medium-term angiographic and clinical follow-up in 22 patients. Am J Neuroradiol. 2001;22:19–26.

    PubMed  CAS  Google Scholar 

  62. Oxley TJ, Dowling RJ, Mitchell PJ, et al. Antiplatelet resistance and thromboembolic complications in neurointerventional procedures. Front Neurol. 2011;2:83.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Patel MR, Jneid H, Derdeyn CP, et al. Arteriotomy closure devices for cardiovascular procedures. Circulation. 2010;122:1882–93.

    Article  PubMed  Google Scholar 

  64. Pierot L, Liebig T, Sychra V, et al. Intrasaccular flow-disruption treatment of intracranial aneurysms: preliminary results of a multicenter clinical study. Am J Neuroradiol. 2012;33:1232–8.

    Article  CAS  PubMed  Google Scholar 

  65. Pierot L, Cognard C, Anxionnat R, et al. CLARITY Investigators Remodeling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate postoperative occlusion than did conventional coil embolization with comparable safety. Radiology. 2011;258:546–52.

    Article  PubMed  Google Scholar 

  66. Pierot L, Costalat C, Moret J, et al. Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study. J Neurosurg. 2016;124:1250–6.

    Article  PubMed  Google Scholar 

  67. Piotin M, Blanc R, Spelle L, et al. Stent-assisted coiling of intracranial aneurysms: clinical and angiographic results in 216 consecutive aneurysms. Stroke. 2010;41:110–5.

    Article  PubMed  Google Scholar 

  68. Poevaya NV, Kalani YS, Steinberg GK, Tse VCK. The transition from hunterian ligation to intracranial aneurysm clips: a historical perspective. Neurosurg Focus. 2006;20:1–7.

    Article  Google Scholar 

  69. Pollak JS, Lee GK, White RI, Dormandy B. Comparison of the mechanical properties of detachable balloons for emboltherapy. J Vasc Intervention Radiol. 1993;4:91–5.

    Article  CAS  Google Scholar 

  70. Proctor M, Black P. Minimally invasive neurosurgery. New York: Humana; 2006.

    Google Scholar 

  71. Rajpal S, Moftakhar R, Bauer AM, et al. Superselective Wada test for ruptured spontaneous fusiform middle cerebral artery aneurysm: a technical case report. J Neurointervent Surg. 2011;3:237–41.

    Article  Google Scholar 

  72. Rayes M, Bahgat DA, Kupsky WJ, Mittal S. Middle cerebral artery pseudoaneurysm formation following stereotactic biopsy. Can J Neurol Sci. 2009;35:664–8.

    Article  Google Scholar 

  73. Raymond J, Guilbert F, Weill A, et al. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke. 2003;34:1398–403.

    Article  PubMed  Google Scholar 

  74. Royal College of Radiologists. Guidelines for radiologist in implementing the NPSA Safe Surgery requirement. London: The Royal College of Radiologists; 2009.

    Google Scholar 

  75. Royal College of Radiologists. Guidance for Fellows in implementing surgical safety checklists for radiological procedures. London: The Royal College of Radiologists; 2013.

    Google Scholar 

  76. Sani S, Lopes D. Treatment of a middle cerebral artery bifurcation aneurysm using a double neuroform stent “Y” configuration and coil embolization: technical case report. Neurosurgery. 2005;57(Suppl 1):E209.

    PubMed  Google Scholar 

  77. Scott DA, Keston P, White PM, Sellar R. Vascular plug for ICA occlusion in cavernous carotid aneurysms: technical note. Neuroradiology. 2008;50:795–8.

    Article  PubMed  Google Scholar 

  78. Serbineko FA. Balloon catheterisation and occlusion of major cerebral vessels. J Neurosurg. 1974;41:125–45.

    Article  Google Scholar 

  79. Shi ZS, Ziegler J, Duckwiler GR, et al. Management of giant middle cerebral artery aneurysms with incorporated branches: partial endovascular coiling or combined extracranial-intracranial bypass-a team approach. Neurosurgery. 2009;65:121–9.

    Article  PubMed  Google Scholar 

  80. Siddiqui AH, Abla AA, Kan P, et al. Panacea or problem: flow diverters in the treatment of symptomatic large or giant fusiform vertebrobasilar aneurysms. J Neurosurg. 2012;116:1258–66.

    Article  PubMed  Google Scholar 

  81. Sluzewski M, van Rooij WJ, Slob MJ, et al. Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils. Radiology. 2004;231:653–8.

    Article  PubMed  Google Scholar 

  82. Taussky P, Lanzino G, Cloft H, Kallmes D. A checklist in the event of aneurysm perforation during coiling. Am J Neuroradiol 2010;31:E59. doi: https://doi.org/10.3174/ajnr.A2140.

    Article  PubMed  Google Scholar 

  83. van der Schaaf IC, Brilstra EH, Buskens E, Rinkel GJE. Endovascular treatment of aneurysms in the cavernous sinus: a systematic review on balloon occlusion of the parent vessel and embolization with coils. Stroke. 2002;33:313–8.

    Article  PubMed  Google Scholar 

  84. van Rooij WJ, Sluzewski M, Slob MJ, et al. Predictive value of angiographic testing for tolerance to therapeutic occlusion of the carotid artery. Am J Neuroradiol. 2005;26:175–8.

    PubMed  Google Scholar 

  85. van Rooij W, Sluzewski M. Endovascular treatment of large and giant aneurysms. Am J Neuroradiol. 2009;30:12–8.

    Article  PubMed  Google Scholar 

  86. van Rooij W, Peluso JP, Bechan RS, Sluzewski M. WEB treatment of ruptured intracranial aneurysms. Am J Neuroradiol. 2016;37:1679–83.

    Article  PubMed  Google Scholar 

  87. Wardlaw JM, White PM. The detection and management of unruptured intracranial aneurysms. Brain. 2000;123:205–21.

    Article  PubMed  Google Scholar 

  88. White PM, Wardlaw JM. Unruptured intracranial aneurysms. Neuroradiology. 2003;30:336–50.

    CAS  Google Scholar 

  89. White PM, Lewis SC, Gholkar AG, et al. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial. Lancet. 2011;377:1655–62.

    Article  CAS  PubMed  Google Scholar 

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White, P., du Plessis, J., Mitra, D. (2018). An Overview of the Endovascular Treatment of Intracranial Aneurysms. In: Lanzer, P. (eds) Textbook of Catheter-Based Cardiovascular Interventions. Springer, Cham. https://doi.org/10.1007/978-3-319-55994-0_68

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