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Upper Urinary Tract Carcinoma In Situ

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Urothelial Malignancies of the Upper Urinary Tract

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Abstract

Upper tract carcinoma in situ (UTCIS) is a non-muscle invasive, high-grade cancer involving the epithelial lining of the renal pelvis, calyces, and ureter. While progression to muscle invasion or metastasis occurs infrequently, UTCIS remains a vexing clinical conundrum for diagnosis, therapy, and subsequent surveillance. Organ preservation remains a central tenet in the management of UTCIS with topical intracavitary instillation playing a critical role to achieve this goal. Nonetheless, owing to the uncommon presentation of UTCIS, treatment paradigms and algorithms are often extrapolated from management of bladder CIS. In that regard, acknowledging that the clinical behavior between these two entities is distinct, prospective evaluation focusing on the UTCIS patient cohort is critical for the future.

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Author information

Authors and Affiliations

  1. Division of Urology, Penn State Milton S. Hershey Medical Center, 500 University Drive, C4830F, Hershey, 17033, PA, USA

    Jay D. Raman

  2. Department of Pathology, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, 17033, PA, USA

    Joshua L. Warrick

  3. Department of Surgery (Urology), University of Texas Houston, 6410 Fannin Street, Houston, 77030, TX, USA

    Grant P. Redrow

  4. Department of Urology, University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Houston, 77030, TX, USA

    Surena F. Matin

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  1. Jay D. Raman
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  2. Joshua L. Warrick
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  4. Surena F. Matin
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Correspondence to Jay D. Raman .

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Editors and Affiliations

  1. Chief, Section of Endourology and Minimally Invasive Urology, Westchester Medical Health Network, Valhalla, New York, USA

    Majid Eshghi

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Raman, J.D., Warrick, J.L., Redrow, G.P., Matin, S.F. (2018). Upper Urinary Tract Carcinoma In Situ. In: Eshghi, M. (eds) Urothelial Malignancies of the Upper Urinary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-51263-1_8

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  • DOI: https://doi.org/10.1007/978-3-319-51263-1_8

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