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Nutrition, Adolescent Pregnancy and Bone

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Nutritional Influences on Bone Health

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Abstract

Pregnancy during adolescence often occurs before peak bone mass has been fully consolidated. This may have short or long-term implications for maternal, fetal and neonatal skeletal health. Optimal calcium and vitamin D intake are essential for bone health, but data regarding metabolism of these nutrients in relation to skeletal health among pregnant teens remains limited. This review summarizes calcium and vitamin D homeostasis in relation to bone outcomes in the pregnant teen and her neonate, and adult pregnancy is used as a reference for comparison throughout. The conclusion highlights key gaps in knowledge and challenges for future work in this area.

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References

  1. Control CfD. Vital signs. CDC [Internet]; 2011.

    Google Scholar 

  2. Prevention USCfDCa. Preventing repeat teen births. Vital signs [Internet]. 2013 06/15/15 [cited 2015 06/15/2015].

    Google Scholar 

  3. Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heaney RP. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. J Clin Invest. 1994;93(2):799–808.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Matkovic V, Fontana D, Tominac C, Goel P, Chesnut CH. Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. Am J Clin Nutr. 1990;52(5):878–88.

    CAS  PubMed  Google Scholar 

  5. Forbes GB. Calcium accumulation by the human fetus. Pediatrics. 1976;57(6):976–7.

    CAS  PubMed  Google Scholar 

  6. Bailey DA, Martin AD, McKay HA, Whiting S, Mirwald R. Calcium accretion in girls and boys during puberty: a longitudinal analysis. J Bone Miner Res. 2000;15(11):2245–50.

    Article  CAS  PubMed  Google Scholar 

  7. Abrams SA, O’Brien KO, Liang LK, Stuff JE. Differences in calcium absorption and kinetics between black and white girls aged 5–16 years. J Bone Miner Res. 1995;10(5):829–33.

    Article  CAS  PubMed  Google Scholar 

  8. Aloia JF. African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. Am J Clin Nutr. 2008;88(2):545S–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Martin JA, Hamilton BE, Osterman MJ, Curtin SC, Matthews TJ. Births: final data for 2013. Natl Vital Stat Rep. 2015;64(1):1–65.

    Google Scholar 

  10. Institute of Medicine FaNB. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011.

    Google Scholar 

  11. Berner LA, Keast DR, Bailey RL, Dwyer JT. Fortified foods are major contributors to nutrient intakes in diets of US children and adolescents. J Acad Nutr Diet. 2014;114(7):1009–22.e8.

    Article  PubMed  Google Scholar 

  12. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.

    Article  CAS  PubMed  Google Scholar 

  13. Heaney RP, Skillman TG. Calcium metabolism in normal human pregnancy. J Clin Endocrinol Metab. 1971;33(4):661–70.

    Article  CAS  PubMed  Google Scholar 

  14. Ritchie LD, Fung EB, Halloran BP, Turnlund JR, Van Loan MD, Cann CE, King JC. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr. 1998;67(4):693–701.

    CAS  PubMed  Google Scholar 

  15. O’Brien KO, Donangelo CM, Zapata CL, Abrams SA, Spencer EM, King JC. Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations. Am J Clin Nutr. 2006;83(2):317–23.

    PubMed  Google Scholar 

  16. Jarjou LM, Laskey MA, Sawo Y, Goldberg GR, Cole TJ, Prentice A. Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake. Am J Clin Nutr. 2010;92(2):450–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;226(10):2341–57.

    Article  Google Scholar 

  18. Brannon PM, Picciano MF. Vitamin D in pregnancy and lactation in humans. Ann Rev Nutr. 2011;31:89–115.

    Article  CAS  Google Scholar 

  19. Zhang JY, Lucey AJ, Horgan R, Kenny LC, Kiely M. Impact of pregnancy on vitamin D status: a longitudinal study. Br J Nutr. 2014;112(7):1081–7.

    Article  CAS  PubMed  Google Scholar 

  20. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014;99(5):1631–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Powe CE, Karumanchi SA, Thadhani R. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014;370(9):880–1.

    CAS  PubMed  Google Scholar 

  22. Hollis BW, Bikle DD. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014;370(9):879–80.

    PubMed  PubMed Central  Google Scholar 

  23. Cross NA, Hillman LS, Allen SH, Krause GF, Vieira NE. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr. 1995;61(3):514–23.

    CAS  PubMed  Google Scholar 

  24. Wagner CL, McNeil R, Hamilton SA, Winkler J, Rodriguez Cook C, Warner G, et al. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am J Obstet Gynecol. 2013;208(2):137.e1–13.

    Article  CAS  Google Scholar 

  25. Young BE, McNanley TJ, Cooper EM, McIntyre AW, Witter F, Harris ZL, O’Brien KO. Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents. J Bone Miner Res. 2012;27(1):177–86.

    Article  CAS  PubMed  Google Scholar 

  26. Kovacs CS. The role of vitamin D in pregnancy and lactation: insights from animal models and clinical studies. Ann Rev Nutr. 2012;32:97–123.

    Article  CAS  Google Scholar 

  27. Scholl TO, Chen X, Stein TP. Maternal calcium metabolic stress and fetal growth. Am J Clin Nutr. 2014;99(4):918–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. O’Brien KO, Donangelo CM, Ritchie LD, Gildengorin G, Abrams S, King JC. Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period. Am J Clin Nutr. 2012;96(1):64–72.

    Article  PubMed  PubMed Central  Google Scholar 

  29. O’Brien KO, Nathanson MS, Mancini J, Witter FR. Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. Am J Clin Nutr. 2003;78(6):1188–93.

    PubMed  Google Scholar 

  30. Olausson H, Goldberg GR, Laskey MA, Schoenmakers I, Jarjou LM, Prentice A. Calcium economy in human pregnancy and lactation. Nutr Res Rev. 2012;25(1):40–67.

    Article  CAS  PubMed  Google Scholar 

  31. Sowers MF, Scholl T, Harris L, Jannausch M. Bone loss in adolescent and adult pregnant women. Obstet Gynecol. 2009;96(2):189–93.

    Google Scholar 

  32. Whisner CM, Young BE, Pressman EK, Queenan RA, Cooper EM, O’Brien KO. Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents. Int J Obes. 2015;39(4):565–70.

    Article  CAS  Google Scholar 

  33. Javaid MK, Crozier SR, Harvey NC, Taylor P, Inskip HM, Godfrey KM, Cooper C, Southhampton Women’s Survey Study Group. Maternal and seasonal predictors of change in calcaneal quantitative ultrasound during pregnancy. J Clin Endocrinol Metab. 2015;90(9):5182–7.

    Article  Google Scholar 

  34. Shim KS. Pubertal growth and epiphyseal fusion. Ann Pediatr Endocrinol Metab. 2015;20(1):8–12.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Lloyd T, Lin HM, Eggli DF, Dodson WC, Demers LM, Legro RS. Adolescent caucasian mothers have reduced adult hip bone density. Fertil Steril. 2002;77(1):136–40.

    Article  PubMed  Google Scholar 

  36. Ward KA, Adams JE, Mughal MZ. Bone status during adolescence, pregnancy and lactation. Curr Opin Obestet Gynecol. 2005;17(4):435–9.

    Article  Google Scholar 

  37. Diogenes ME, Bezerra FF, Rezende EP, Taveira MF, Pinhal I, Donangelo CM. Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial. Am J Clin Nutr. 2013;98(1):82–91.

    Article  CAS  PubMed  Google Scholar 

  38. Cho GJ, Shin JH, Yi KW, Park HT, Kim T, Hur JY, Kim SH. Adolescent pregnancy is associated with osteoporosis in postmenopausal women. Menopause. 2012;19(4):456–60.

    Article  PubMed  Google Scholar 

  39. Wallace JM, Luther JS, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Hay Jr WW. Nutritional modulation of adolescent pregnancy outcome – a review. Placenta. 2006;27(A):S61–8.

    Article  PubMed  Google Scholar 

  40. Chang SC, O’Brien KO, Nathanson MS, Mancini J, Witter FR. Characteristics and risk factors for adverse birth outcomes in pregnant black adolescents. J Pediatr. 2003;43(2):250–7.

    Article  Google Scholar 

  41. Chang SC, O’Brien KO, Nathanson MS, Caulfield LE, Mancini J, Witter FR. Fetal femur length is influenced by maternal dairy intake in pregnant African American adolescents. Am J Clin Nutr. 2003;77(5):1248–54.

    CAS  PubMed  Google Scholar 

  42. Young BE, McNanley TJ, Cooper EM, McIntyre AW, Witter F, Harris ZL, O’Brien KO. Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. Am J Clin Nutr. 2012;95(5):1103–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Diogenes ME, Bezerra FF, Rezende EP, Donangelo CM. Calcium plus vitamin D supplementation during third trimester of pregnancy in adolescents accustomed to low calcium diets did not affect infant bone mass at early lactation in a randomized controlled trial. J Nutr. 2015;145(7):1515–23.

    Article  CAS  PubMed  Google Scholar 

  44. Jarjou LM, Sawo Y, Goldberg GR, Laskey MA, Cole TJ, Prentice A. Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study. Am J Clin Nutr. 2013;98(3):723–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Jarjou LM, Prentice A, Sawo Y, Laskey MA, Bennett J, Goldberg GR, Cole TJ. Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr. 2006;83(3):657–66.

    CAS  PubMed  Google Scholar 

  46. Razzaque MS. Bone-kidney axis in systemic phosphate turnover. Arc Biochem Biophys. 2014;561:154–8.

    Article  CAS  Google Scholar 

  47. Chang SC, O’Brien KO, Nathanson MS, Mancini J, Witter FR. Hemoglobin concentrations influence birth outcomes in pregnant African-American adolescents. J Nutr. 2003;133(7):2348–55.

    CAS  PubMed  Google Scholar 

  48. Zhou LM, Yang WW, Hua JZ, Deng CQ, Tao XG, Stoltzfus RJ. Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. Am J Epidemiol. 1988;148(10):998–1006.

    Article  Google Scholar 

  49. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976–89.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Nutritional Sciences, Cornell University, Rm 230 Savage, Ithaca, NY, 14853, USA

    Kimberly O. O’Brien PhD & Cora M. Best MHS

Authors
  1. Kimberly O. O’Brien PhD
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  2. Cora M. Best MHS
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Correspondence to Kimberly O. O’Brien PhD .

Editor information

Editors and Affiliations

  1. Nutrition and Science, Purdue University, West Lafayette, Indiana, USA

    Connie M. Weaver

  2. Deakin University, Melbourne, Australia

    Robin M. Daly

  3. Geriatrics and Aging Research, University of Zurich, Zurich, Switzerland

    Heike A. Bischoff-Ferrari

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© 2016 Springer International Publishing Switzerland

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O’Brien, K.O., Best, C.M. (2016). Nutrition, Adolescent Pregnancy and Bone. In: Weaver, C., Daly, R., Bischoff-Ferrari, H. (eds) Nutritional Influences on Bone Health. Springer, Cham. https://doi.org/10.1007/978-3-319-32417-3_26

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  • DOI: https://doi.org/10.1007/978-3-319-32417-3_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32415-9

  • Online ISBN: 978-3-319-32417-3

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