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Low-Grade Adenosquamous Carcinoma

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Adenosquamous carcinoma; Infiltrative syringomatous adenoma; Syringomatous squamous tumor

Definition

Low-grade adenosquamous carcinoma (LGASC) of the breast is exceedingly uncommon, and it is characterized by well-developed gland formation mixed with solid nests of squamous cells in a spindle cell background.

Clinical Features

  • Incidence: LGASC belongs to the family of “metaplastic breast cancers,” it represents from 0.2 to 5% of all breast carcinomas. Such a variability of incidence is due to a plethora of terminologies used by different authors to designate these tumors. Consequently, it is not surprising that there are series of metaplastic carcinomas that do not even report a single case of LGASC, while other authors estimate their incidence around 0.58% of the total of invasive breast cancers. The real prevalence of this histotype is probably underestimated due to the diagnostic difficulties in recognizing it correctly. In any case this entity has to be considered...

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References and Further Reading

  • Boecker, W., Stenman, G., Loening, T., Andersson, M. K., Sinn, H. P., Barth, P., Oberhellmann, F., Bos, I., Berg, T., Marusic, Z., Samoilova, V., & Buchwalow, I. (2014). Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: Evidence for a common origin. Histopathology, 65, 9–23.

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  • Geyer, F. C., Lambros, M. B. K., Natrajan, R., Mehta, R., Mackay, A., Savage, K., Parry, S., Ashworth, A., Badve, S., & Reis-Filho, J. S. (2010). Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast. Modern Pathology, 23, 951–960.

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  • Kawaguchi, K., & Shin, S. J. (2012). Immunohistochemical staining characteristics of low-grade adenosquamous carcinoma of the breast. American Journal of Surgical Pathology, 36, 1009–1020.

    Article  PubMed  Google Scholar 

  • Rosen, P. P., & Ernsberger, D. (1987). Low-grade adenosquamous carcinoma: A variant of metaplastic mammary carcinoma. American Journal of Surgical Pathology, 11, 351–358.

    Article  CAS  PubMed  Google Scholar 

  • Senger, J. L., Meiers, P., & Kanthan, R. (2015). Bilateral synchronous low-grade adenosquamous carcinoma of the breast: A case report with review of current literature. International Journal of Surgery Case Reports, 14, 53–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Experimental Medicine, Section of Pathologic Anatomy and Histology, Medical School, University of Perugia, Perugia, Italy

    Angelo Sidoni

Authors
  1. Angelo Sidoni
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Corresponding author

Correspondence to Angelo Sidoni .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Sidoni, A. (2018). Low-Grade Adenosquamous Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4712-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4712-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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