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Phosphine and Metal Phosphide

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Abstract

Pesticides and grain fumigants play an important part in the development of agriculture and enhance grain production in the world. Their use has led to improved quantity and better quality of crops, resulting in better availability of food grains to the population. Despite these benefits, the increased availability of pesticides and grain fumigants has led to them being misused as agents of self-harm [1, 2].

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References

  1. Murali R, Bhalla A, Singh D, Singh S. Acute poisoning: 15 yr experience of a large north-west Indian hospital. Clin Toxicol. 2008;47:1–4. doi:10.1080/15563650701885807.

    Google Scholar 

  2. Gupta S, Ahlawat SK. Aluminium phosphide poisoning: a review. J Toxicol Clin Toxicol. 1995;33:19–24.

    Article  CAS  PubMed  Google Scholar 

  3. Goldman LR, Menge D, Epstien DM, et al. Acute symptoms in person residing near a field treated with soil fumigants. West J Med. 1987;147:95–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Shadnia S. Fumigants, Chapter 111. In: Hoffman R, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, editors. Goldfrank’s toxicologic emergencies. 10th ed. New York: McGraw Hill Education; 2015. p. 1381–8.

    Google Scholar 

  5. Singh S, Dilawari JB, Vashist R, Malhotra HS, Sharma BK. Aluminium phosphide ingestion in man. Br Med J. 1985;290:1110–1.

    Article  CAS  Google Scholar 

  6. Siwach SB, Yadav DR, Arora DR, Arora B, Dalal SJ. Acute aluminium phosphide poisoning. An epidemiological, clinical and histopathological study. J Assoc Physcians India. 1988;36:594–6.

    CAS  Google Scholar 

  7. Chugh SN, Chugh K, Ram S, Malhotra KC. Electrocardiographic abnormalities in aluminium phosphide poisoning with special reference to its incidence, pathogenesis, mortality and histopathology. J Indian Med Assoc. 1991;89:32–5.

    CAS  PubMed  Google Scholar 

  8. Khosla SN, Chugh SN, Nand N, Saini RS. Systemic involvement in aluminum phosphide poisoning. J Assoc Physcians India. 1986;34:227–30.

    CAS  Google Scholar 

  9. Bajaj R, Wasir HS, Aggarwal R, et al. Clinical toxicity and outcome in eleven intensively monitored patients. Natl Med J India. 1988;1:270–4.

    Google Scholar 

  10. Kalra R, Elhence GP, Mehrotra ML, Srivastava SSL, Mitra A, Aggarwal R, Ram A. A study of aluminium phosphide poisoning with special reference to electrocardiographic changes. J Assoc Physcians India. 1990;38:471–3.

    Google Scholar 

  11. Moghdamnia AA, Abdollahi M. An epidemiological study of poisoning in northern Islamic Republic of Iran. East Mediterr Health J. 2002;8:88–94.

    Google Scholar 

  12. Abder-Rahman HA, Battah AH, Ibraheem YM, Shomaf MS, el- Batanich N. Aluminum phosphide fatalities, new local experience. Med Sci Law. 2000;40:164–813.

    CAS  PubMed  Google Scholar 

  13. Akkaoui M, Achour S, Abidi K, Himdi B, Madani A, Zeggwagh AA, Abouqal R. Reversible myocardial injury associated with aluminium phosphide poisoning. Clin Toxicol. 2007;45(6):728–31.

    Article  CAS  Google Scholar 

  14. Nocera A, Levitin HW, Hilton JM. Dangerous bodies: a case of fatal aluminium phosphide poisoning. Med J Aust. 2000;173:133–5.

    CAS  PubMed  Google Scholar 

  15. Popp W, Mentfewitz J, Gotz R, et al. Phosphine gas poisoning in a German office. Lancet. 2002;359:1574.

    Article  PubMed  Google Scholar 

  16. Brautbar N, Howard J. Phosphine toxicity: report of two cases and review of the literature. Toxicol Ind Health. 2002;18(2):71–5.

    Article  CAS  PubMed  Google Scholar 

  17. Bogle RG, Theron P, Brooks P, et al. Aluminium phosphide poisoning. Emerg Med J. 2006;23:e3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Chugh SN. Aluminium phosphide poisoning: present status and management. J Assoc Physicians India. 1992;40:401–5.

    CAS  PubMed  Google Scholar 

  19. Chugh SN, Malhotra KC. Acute pericarditis in aluminium phosphide poisoning. J Assoc Physicians India. 1992;40:564.

    CAS  PubMed  Google Scholar 

  20. Zaebst DD, Blade LM, Burroughs GE, Morelli-Schroth P, Woodfin WJ. Phosphine exposures in grain elevators during fumigation with aluminium phosphide. Appl Ind Hyg. 1988;3:146–54.

    Article  CAS  Google Scholar 

  21. International program on chemical safety for phosphine and selected metal phosphides. Environmental Health Criteria 73. Geneva: WHO;1988. http://www.inchem.org/documents/ehc/ehc73.htm. Accessed 23 Dec 2015.

  22. Shadania S, Soltaninejad K. Spontaneous ignition due to intentional acute aluminium phosphide poisoning. J Emerg Med. 2011;40:179–81.

    Article  Google Scholar 

  23. Wahab A, Rabbani MU, Wahab S, et al. Spontaneous self ignition in case of acute aluminium phosphide poisoning. Am J Emerg Med. 2009;27:752.e5–6.

    Article  Google Scholar 

  24. Yadav J, Ahlawat BK, Dubey BP, et al. Spontaneous ignition in case of celphos poisoning. Am J Forensic Med Pathol. 2007;28:353–5.

    Article  PubMed  Google Scholar 

  25. Balali M. International Program on Chemical Safety (IPCS): Phosphine: poison information monograph 865. Nov 1991. http://www.inchem.org/documents/pims/chemical/pims865.htm. Accessed 23 Dec 2015.

  26. Goel A, Aggarwal P. Pesticide poisoning. Natl Med J India. 2007;20:182–91.

    PubMed  Google Scholar 

  27. Plunkett ER. Handbook of industrial toxicology. 3rd ed. New York: Chemical Publishing Company; 1987. p. 430–2.

    Google Scholar 

  28. Tripathy SK, Gautam CS, Sharma PL. Clinical pharmacology of aluminium phosphide poisoning. Indian J Pharm. 1992;24:134–7.

    Google Scholar 

  29. Anger F, Paysant F, Brousse F, et al. Fatal aluminium phosphide poisoning. J Anal Toxicol. 2000;24:90–2.

    Article  CAS  PubMed  Google Scholar 

  30. Chugh SN, Pal R, Singh V, et al. Serial blood phosphine levels in acute aluminium phosphide poisoning. J Assoc Physicians India. 1996;104:190–3.

    CAS  Google Scholar 

  31. Jain AK, Nigam M, Garg SD, Dubey BP, Arora A. Aluminium phosphide poisoning Autopsy findings. JIAFM. 2005;27:35–9.

    Google Scholar 

  32. Gurjar M, Baronia AK, Azim A, et al. Managing aluminium phosphide poisoning. J Emerg Trauma Shock. 2011;4:378–84.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Nakakita H, Katsumata Y, Ozawa T. The effect of phosphine on the respiration of rat liver mitochondria. J Biochem. 1971;68:589–93.

    Google Scholar 

  34. Chefurka W, Kashi KP, Bond EJ. The effect of phosphine on electron transport in mitochondria. Pesticide Biochem Physio. 1976;6:65–84.

    Article  CAS  Google Scholar 

  35. Price NR, Dance SJ. Some biochemical aspect of phosphine action and resistance in three stored product beetles. Comp Biochem Physiol. 1983;76:277–81.

    CAS  Google Scholar 

  36. Dua R, Gill KD. Effect of aluminium phosphide exposure on kinetic properties of cytochrome oxidase and mitochondrial energy metabolism in rat brain. Biochim Biophys Acta. 1674;2004:4–11.

    Google Scholar 

  37. Dua R, Gill KD. Aluminum phosphide exposure: implications on rat brain lipid peroxidation and anti-oxidant defence system. Pharmacol Toxicol. 2001;89:315–9.

    Article  CAS  PubMed  Google Scholar 

  38. Singh S, Kumar S, Kaur A, Bhalla A, Gill KD. Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol. 2006;44(3):155–8.

    Article  CAS  Google Scholar 

  39. Chugh SN, Mittal A, Seth S, et al. Lipid peroxidation in acute aluminium poisoning. J Assoc Physicians India. 1995;43:265–6.

    CAS  PubMed  Google Scholar 

  40. Chugh SN, Arora V, Sharma A, et al. Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning. Indian J Med Res. 1996;104:190–3.

    CAS  PubMed  Google Scholar 

  41. Anand R, Kumari P, Kaushal A, Bal A, Wani WY, Sunkaria A, Dua R, Singh S, Bhalla A, Gill KD. Effect of aluminium phosphide exposure on rats-a biochemical and histological correlation. Toxicol Lett. 2012;215:62–9.

    Article  CAS  PubMed  Google Scholar 

  42. Sharma N, Mahi S, Bhalla A, APAMT 2007) Bhalla A, Mahi S, Sharma N, Singh S. Polyserositis: an unusual complication of aluminium phosphide poisoning. Asia Pac J Med Toxicol. 2012;1(1): 1407.

    Google Scholar 

  43. NIOSH: Preventing phosphine and explosions during fumigation. Publication No 11–126. http://www.cdc.gov/niosh/docs/99-126/pdfs/99-126.pdf. Accessed 22 Jan 2016.

  44. Sudakin DL. Occupational exposure to aluminium phosphide and phosphine gas? A suspected case report and review of literature. Hum Exp Toxicol. 2005;24:27–33.

    Article  CAS  PubMed  Google Scholar 

  45. Bajaj R, Wasir HS. Epidemic aluminium phosphide poisoning in northern India. Lancet. 1988;1(8589):820–1.

    Article  Google Scholar 

  46. Singh S, Singh D, Wig N, Inderjit, Sharma BK. Aluminium phosphide ingestion- A clinico-pathologic study. J Toxicol Clin Toxicol. 1996;34:703–6.

    Article  CAS  PubMed  Google Scholar 

  47. Chugh SN, Sant R, Chugh K, Malhotra KC. Spot diagnosis of aluminium phosphide ingestion; an application of simple test. J Assoc Physcians India. 1989;37:219–20.

    CAS  Google Scholar 

  48. Mathiharan K, Patnaik AK. Modi’s medical jurisprudence and toxicology. 23rd ed. Nagpur (India): LexisNexis Butterworth Wadhwa;2005. p. 436.

    Google Scholar 

  49. Bansal YS, Singh D, Settia P, Attrey SD. Precautions while conducting silver nitrate test for aluminium phosphide. J Ind Acad For en Med. 2006;28(3):88–90.

    Google Scholar 

  50. Musshoff F. Gas chromatographic analysis of phosphine in biological material in a case of suicide. Forensic Sci Int. 2008;177:e35–8.

    Article  CAS  PubMed  Google Scholar 

  51. Vins Jansen A, Thrane KE. Gas chromatographic determination of phosphine in ambient air. Analysis. 1978;103:1195–8.

    CAS  Google Scholar 

  52. Jain SM, Bharani A, Sepaha GC, et al. Electrocardiographic changes in aluminium phosphide poisoning. J Assoc Physicians India. 1985;33:406–9.

    CAS  PubMed  Google Scholar 

  53. Soltaninejad K, Beyranvand MR, Momenzedeh SA, et al. Electrocardiographic findings and cardiac manifestations in acute aluminium phosphide poisoning. J Forenisc Legal Med. 2012;19:291–3.

    Article  Google Scholar 

  54. Siwach SB, Singh H, Jagdish, et al. Cardiac arrhythmias in aluminium phosphide poisoning studied by continuous holter and cardioscopic monitoring. J Assoc Physicians India. 1998;46:598–601.

    CAS  PubMed  Google Scholar 

  55. Bhasin P, Mittal HS, Mitra A. An echocardiographic study in aluminium phosphide poisoning. (abstract). J assoc Physicians India. 1991; 39:851.

    Google Scholar 

  56. Gupta MS, Malik A, Sharma VK, et al. Cardiovascular manifestations in aluminium phosphide poisoning with special reference to echocardiographic changes. J Assoc Physicians India. 1995;43:773.

    CAS  PubMed  Google Scholar 

  57. Proudfoot AT. Zinc and aluminium phosphide poisoning. Clin Toxicol. 2009;47:89–100.

    Article  CAS  Google Scholar 

  58. Chugh SN, Kumar P, Sharma A, et al. Magnesium status and magnesium sulphate therapy in acute aluminium phosphide intoxication. Magnes Res. 1994;7:289–94.

    CAS  PubMed  Google Scholar 

  59. Chugh SN, Kumar P, Aggarwal HK, et al. Efficacy of magnesium sulphate in acute aluminium phosphide poisoning. J Assoc Physicians India. 1994;42:373–5.

    CAS  PubMed  Google Scholar 

  60. Singh RB, Saharia RB, Sharma VK. Can aluminium phosphide cause hypermagnesemia? A study of 121 patients. Magnes Trace Elem. 1990;9:212–8.

    CAS  PubMed  Google Scholar 

  61. Singh RB, Singh RG, Singh U. Hypermagnesemia following aluminium phosphide poisoning. Int J Ciln Pharm Ther Toxicol. 1991;29:82–5.

    CAS  Google Scholar 

  62. Chugh SN, Kishore K, Aggarwal N, et al. Hypoglycaemia in acute aluminium phosphide poisoning. J Assoc Physicians India. 2000;48:855–6.

    CAS  PubMed  Google Scholar 

  63. Frangides CY, Pneumatikos IA. Persistent severe hypoglycaemia in severe aluminium phosphide poisoning. Intensive Care Med. 2002;28:223.

    Article  PubMed  Google Scholar 

  64. Mehrpour O, Dolati M, Soltaninejad K, et al. Evaluation of histopathological changes in fatal aluminium phosphide poisoning. Indian J Forensic Med Toxicol. 2008;2:34–8.

    Google Scholar 

  65. Maitai CK, Njoroge DK, Abuga KO, et al. Investigation of possible antidotal effects of activated charcoal, sodium bicarbonate, hydrogen peroxide and potassium permanganate in zinc phosphide poisoning. East Central Afr J Phram Sci. 2002;5:38–41.

    Google Scholar 

  66. Pajoumand A, Jalali N, Abdollahi M, et al. Survival after acute aluminium phosphide poisoning. J Pharm Pract Res. 2002;32:297–9.

    Article  Google Scholar 

  67. Goswami L, Bindal M, Sen P, et al. Fat and oil inhibit release of phosphine from aluminium phosphide-its clinical implications. Indian J Exp Biol. 1994;32:647–9.

    CAS  PubMed  Google Scholar 

  68. Shadnia S, Rahimi M, Pajoumand A, et al. Successful treatment of acute aluminium phosphide poisoning, possible benefit of coconut oil. Hum Exp Toxicol. 2005;24:215–8.

    Article  CAS  PubMed  Google Scholar 

  69. Mital HS, Mehrotra TN, Dwivedi KK, et al. A study of aluminium phosphide poisoning with special reference to silver nitrate test. J Assoc Physcians India. 1992;40:473–4.

    CAS  Google Scholar 

  70. Christophers AJ, Singh S, Goddard DG. Dangerous bodies: a case of fatal aluminium phosphide poisoning. MJA. 2002;176(8):403.

    PubMed  Google Scholar 

  71. Abu-Zidan FM. Optimizing the value of measuring inferior vena cava diameter in shocked patients. World J Crit Care Med. 2016;5(1):7–11.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Moazezi Z, Abedi SH. A successful management of aluminium phosphide intoxication. Caspian J Intern Med. 2011;2(3):286–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Mehrpour O, Ferzaneh E, Abdollahi M. Successful treatment of aluminium phosphide poisoning with Digoxin: a case report and review of literature. Int J Pharmacol. 2011;7:761–4.

    Article  CAS  Google Scholar 

  74. Sanei-zadeh H, Farajidana H. Is there a role of digoxin in the management of aluminium phosphide poisoning? Med Hypotheses. 2011;76:756–66.

    Google Scholar 

  75. Chugh SN, Ram S, Arora RB, Saini AS, Malhotra KC. Adrenocortical involvement in aluminium phosphide poisoning. Indian J Med Res. 1989;90:289–94.

    CAS  PubMed  Google Scholar 

  76. Azad A, Lall SB, Mitra S. Effect of N-acetylcysteine and L-NAME on aluminum phosphide induced cardiovascular toxicity in rats. Acta Pharmacol Sin. 2001;22:298–304.

    CAS  PubMed  Google Scholar 

  77. Tehrani H, Halvaie Z, Shadnia S, et al. Protective effects of N acetyl cysteine on aluminium phosphide induced oxidative stress in acute human poisoning. Clin Toxicol. 2013;51:23–8.

    Article  CAS  Google Scholar 

  78. Bhalla A, Jyotinath P, Singh S, Sharma N. Antioxidant therapy in patients with severe aluminium phosphide poisoning-A pilot study. Indian Jr Critical care medicine (in press).

    Google Scholar 

  79. Marquis JK, Lerrick AJ. Non competitive inhibition by aluminium, scandium and yttrium of acetylcholinesterase from electrophorus electricus. Biochem Pharmacol. 1982;31:1437–40.

    Article  CAS  PubMed  Google Scholar 

  80. Marquis JK. Aluminium inhibition of human serum cholinesterase. Bull Environ Contam Toxicol. 1983;31:164–9.

    Article  CAS  PubMed  Google Scholar 

  81. Potter WT, Garry VF, Kelly JT, et al. Radiometric assay of red cell and plasma cholinesterase in pesticide appliers of Minnesota. Toxicol Appl Pharmacol. 1993;119:150–5.

    Article  CAS  PubMed  Google Scholar 

  82. Hassanian Moghaddam H, Pajoumand A. Two years epidemiological survey of aluminium phosphide poisoning. Iranian J Toxicol. 2007;1:1–9.

    Google Scholar 

  83. Siddaiah L, Adhyapak S, Jaydev S, et al. Intra aortic balloon pump in toxic myocarditis due to aluminium phosphide poisoning. J Medical Toxicol. 2009;5:80–3.

    Article  Google Scholar 

  84. Hassanian Moghaddam H, Zamani N, Rahimii M, Hajesmaeili M, Teherkhani M, Sadeghi R. Successful treatment of aluminium phosphide poisoning by extra corporeal membrane oxygenation. Basic Clin Pharmacol Toxicol. 2016;118(3):243–6.

    Article  CAS  PubMed  Google Scholar 

  85. Saidi H, Shokranesh F, Ghafouri HB, et al. Effect of hyperbaric oxygen on survival time of aluminium phosphide intoxicated rats. J Res Med Sci. 2011;16:1306–12.

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Misra SP, Dwivedi M. Aluminium phosphide induced esophageal strictures. J Clin Gastroenterol. 2009;43(5):405–9.

    Article  PubMed  Google Scholar 

  87. Kochhar R, Dutta U, Poornachandra KS, Vaiphai K, Bhagat S, Nagi B, Singh K. Clinical profile and outcome of aluminium phosphide induced esophageal strictures. J Med Toxicol. 2010;6(3):301–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Jain RK, Gouda NB, Sharma VK, Dubey TN, Shende A, Malik R, Tiwari G. Esophageal complications following aluminium phosphide ingestion: an emerging issue among survivors of poisoning. Dysphagia. 2009;25:271–6.

    Article  PubMed  Google Scholar 

  89. Louriz M, Dendane T, Abidi K, Madani N, Abouqal R, Zeggwagh AA. Prognostic factors of acute aluminum phosphide poisoning. Indian J Med Sci. 2009;63(6):227–34.

    Article  CAS  PubMed  Google Scholar 

  90. Shadnia S, Mehrpour O, Soltaninejad S. A simplified acute physiology score in the prediction of acute aluminum phosphide poisoning outcome. Indian Jr Med Sci. 2010;64:532–5.

    Article  Google Scholar 

  91. Singh S, Bhalla A. Aluminium phosphide poisoning. Jr Mahatama Gandhi Inst Med Sci. 2015;20:15–9.

    Article  Google Scholar 

  92. Bhalla A, Jhuria L, Sharma N, Kumar S, Singh S. Comparing three point PGI scoring system with SAPS II and SOFA score as prognostic marker in acute aluminium phosphide poisoning. 13th APAMT Meeting 2014, Shenyang. www.asiatox.org/13thAPAMT/OP/oral presentation_pdf. Accessed 24 Mar 2016.

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Correspondence to Ashish Bhalla .

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Grading System for Levels of Evidence Supporting Recommendations in Critical Care Toxicology, 2nd Edition

Grading System for Levels of Evidence Supporting Recommendations in Critical Care Toxicology, 2nd Edition

  1. I

    Evidence obtained from at least one properly randomized controlled trial

  2. II-1

    Evidence obtained from well-designed controlled trials without randomization

  3. II-2

    Evidence obtained from well-designed cohort or case–control analytic studies, preferably from more than one center or research group.

  4. II-3

    Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments (such as the results of the introduction of penicillin treatment in the 1940s) could also be regarded as this type of evidence

  5. III

    Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees

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Bhalla, A. (2016). Phosphine and Metal Phosphide. In: Brent, J., Burkhart, K., Dargan, P., Hatten, B., Megarbane, B., Palmer, R. (eds) Critical Care Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-20790-2_84-1

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