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Hereditary Pancreatitis and Chronic Pancreatitis

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Textbook of Pediatric Gastroenterology, Hepatology and Nutrition

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Abstract

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas characterized by irreversible structural changes and fibrotic replacement of the pancreatic parenchyma leading to permanent loss of exocrine and endocrine function (Lowe, Curr Gastroenterol Rep 6(3):240–246, 2004; Pediatric practice gastroenterology, McGraw Hill, New York, pp. 428–440, 2010; Morinville et al., J Pediatr Gastroenterol Nutr 55(3):261–265, 2012; Nydegger et al., J Gastroenterol Hepatol 21(3):499–509, 2006). The overall incidence of CP in adults is 2–4 per 100,000 persons per year and has increased over the years (Yadav et al., Am J Gastroenterol 106(12):2192–2199, 2011; Spanier et al., World J Gastroenterol. 19(20):3018–3026, 2013). The prevalence of CP in childhood is unknown, but estimated to be low. This chapter outlines the main forms of CP in children, with an emphasis on the hereditary forms.

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Authors and Affiliations

  1. Stead Family Department of Pediatrics, University of Iowa Children’s Hospital, 2865 JPP Pediatrics, 200 Hawkins Drive, 52242, Iowa City, IA, USA

    Aliye Uc

  2. Pediatric Gastroenterology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel

    Michael Wilschanski

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  1. Aliye Uc
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Correspondence to Aliye Uc .

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Editors and Affiliations

  1. Department of Pediatrics, University of Chicago, Chicago, Illinois, USA

    Stefano Guandalini

  2. Clinical Director Child Health King’s College Hospital, Professor and Director Pediatric Liver, GI and Nutrition Center, London, United Kingdom

    Anil Dhawan

  3. Department of Pediatrics, Hebrew University Hadassah Hospital, Jerusalem, Israel

    David Branski

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Uc, A., Wilschanski, M. (2016). Hereditary Pancreatitis and Chronic Pancreatitis. In: Guandalini, S., Dhawan, A., Branski, D. (eds) Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. Springer, Cham. https://doi.org/10.1007/978-3-319-17169-2_34

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