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Vascular Manifestations in COVID 19

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Neuroimaging of Covid-19. First Insights based on Clinical Cases

Abstract

Neurological symptoms described in COVID-19 infected patients (hypo-ageusia, anosmia, confusion, seizures, etc.) are often associated to presence of stroke and/or brain hemorrhages that sometimes can occur together. As COVID-19 has spread around the world, evidence has grown for an association with cerebrovascular disease. The association between COVID-19 and cerebrovascular complications were reported in an early retrospective case series from Wuhan [1], Italy [2, 3], and Netherlands [4] and extensively reported in Chap. 2.

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References

  1. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77:683–90.

    Google Scholar 

  2. Lodigiani C, Iapichino G, Carenzo L, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14.

    Google Scholar 

  3. Benussi A, Pilotto A, Premi E, et al. Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy. Neurology. 2020;95:e910.

    Google Scholar 

  4. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–7.

    Google Scholar 

  5. Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T. Neurological associations of COVID-19. Lancet Neurol. 2020;19:767–83.

    Google Scholar 

  6. Merkler AE, Parikh NS, Mir S, et al. Risk of ischemic stroke in patients with Covid-19 versus patients with influenza. medRxiv. 2020; https://doi.org/10.1101/2020.05.18.20105494.

  7. Wang A, Mandigo GK, Yim PD, Meyers PM, Lavine SD. Stroke and mechanical thrombectomy in patients with COVID-19: technical observations and patient characteristics. J Neurointervent Surg. 2020;12:648.

    Google Scholar 

  8. Simon E, Benjamin M, Hocine R, et al. Treatment of acute ischemic stroke due to large vessel occlusion with COVID-19. Stroke. 2020;51:2540–3.

    Google Scholar 

  9. Sweid A, Hammoud B, Bekelis K, et al. Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019. Int J Stroke. 2020;15:733–42.

    Google Scholar 

  10. Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age- and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78:2166–71.

    Google Scholar 

  11. Wang M, Monticone RE, Lakatta EG. Proinflammation of aging central arteries: a mini-review. Gerontology. 2014;60:519–29.

    Google Scholar 

  12. Poyiadji N, Cormier P, Patel PY, et al. Acute pulmonary embolism and COVID-19. Radiology. 2020;297:E335.

    Google Scholar 

  13. Arbour N, Day R, Newcombe J, Talbot PJ. Neuroinvasion by human respiratory coronaviruses. J Virol. 2000;74:8913.

    Google Scholar 

  14. Desforges M, Le Coupanec A, Brison E, Meessen-Pinard M, Talbot PJ. Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Adv Exp Med Biol. 2014;807:75–96.

    Google Scholar 

  15. Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, Yaffe MB, Moore HB, Barrett CD. Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): a case series. J Thromb Haemost. 2020;18:1752–5.

    Google Scholar 

  16. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, Wang H, Wan J, Wang X, Lu Z. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5:811–8.

    Google Scholar 

  17. Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Synd. 2020;14:247–50.

    Google Scholar 

  18. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–9.

    Google Scholar 

  19. Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, Bi Z, Zhao Y. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109:531–8.

    Google Scholar 

  20. Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke. 2003;34:2518–32.

    Google Scholar 

  21. Shi K, Tian D-C, Li Z-G, Ducruet AF, Lawton MT, Shi F-D. Global brain inflammation in stroke. Lancet Neurol. 2019;18:1058–66.

    Google Scholar 

  22. Arenillas Juan F, José Á-S, Molina Carlos A, Pilar C, Joan M, Álex R, Bernardo I, Manuel Q. C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke. 2003;34:2463–8.

    Google Scholar 

  23. Sarzi-Puttini P, Giorgi V, Sirotti S, Marotto D, Ardizzone S, Rizzardini G, Antinori S, Galli M. COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? Clin Exp Rheumatol. 2020;38:337–42.

    Google Scholar 

  24. Bhatia R, Sylaja PN, Srivastava MVP, et al. Consensus statement - suggested recommendations for acute stroke management during the COVID-19 pandemic: expert group on behalf of the Indian Stroke Association. Ann Indian Acad Neurol. 2020;23:S15–23.

    Google Scholar 

  25. Li Y, Li M, Wang M, Zhou Y, Chang J, Xian Y, Wang D, Mao L, Jin H, Hu B. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5:279.

    Google Scholar 

  26. Baracchini C, Pieroni A, Viaro F, Cianci V, Cattelan AM, Tiberio I, Munari M, Causin F. Acute stroke management pathway during Coronavirus-19 pandemic. Neurol Sci. 2020;41:1003–5.

    Google Scholar 

  27. Khosravani H, Rajendram P, Notario L, Chapman MG, Menon BK. Protected code stroke: hyperacute stroke management during the coronavirus disease 2019 (COVID-19) pandemic. Stroke. 2020;51:1891–5.

    Google Scholar 

  28. AHA/ASA Stroke Council Leadership. Temporary emergency guidance to US Stroke Centers during the coronavirus disease 2019 (COVID-19) pandemic. Stroke. 2020;51:1910–2.

    Google Scholar 

  29. Dogra S, Jain R, Cao M, et al. Hemorrhagic stroke and anticoagulation in COVID-19. J Stroke Cerebrovasc Dis. 2020;29:104984.

    Google Scholar 

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Authors and Affiliations

  1. Neuroradiology Department, Papa Giovanni XXIII Hospital, Bergamo, Italy

    Antonino Barletta, Maria Luisa Colleoni, Luca Quilici, Gabriele Gallizioli & Simonetta Gerevini

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  1. Antonino Barletta
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  2. Maria Luisa Colleoni
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  3. Luca Quilici
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  4. Gabriele Gallizioli
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  5. Simonetta Gerevini
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Correspondence to Simonetta Gerevini .

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Editors and Affiliations

  1. Neuroradiology Department, Papa Giovanni XXIII Hospital, Bergamo, Italy

    Simonetta Gerevini M.D.

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Barletta, A., Colleoni, M.L., Quilici, L., Gallizioli, G., Gerevini, S. (2021). Vascular Manifestations in COVID 19. In: Gerevini M.D., S. (eds) Neuroimaging of Covid-19. First Insights based on Clinical Cases. Springer, Cham. https://doi.org/10.1007/978-3-030-67521-9_3

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  • DOI: https://doi.org/10.1007/978-3-030-67521-9_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-67520-2

  • Online ISBN: 978-3-030-67521-9

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