Abstract
The paper presents the thermal characterization of Fe-Mn oxide nanoparticles with high SAR value, when used in magnetic field hyperthermia conditions. The synthesis shows good reproducibility. Finally, the paper presents a possible use of the presented nanoparticles included in PLGA nanocarriers for biomedical application.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Jordan, A., Scholz, R., Wust, P., Fahling, H., Roland felix: magnetic fluid hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J. Magn. Magn. Mater. 201, 413–419 (1999). https://doi.org/10.1016/s0304-8853(99)00088-8
Rosensweig, R.E.: Heating magnetic fluid with alternating magnetic field. J. Magn. Magn. Mater. 252, 370 (2002)
Baronzio, G.: A brief overview of hyperthermia in cancer treatment. J. Integr. Oncol. 03 (2014). https://doi.org/10.4172/2329-6771.1000115
Goya, G.F., Asín, L., Ibarra, M.R.: Cell death induced by AC magnetic fields and magnetic nanoparticles: current state and perspectives. Int. J. Hyperth. 29, 810–818 (2013)
Fortin, J.P., Gazeau, F., Wilhelm, C.: Intracellular heating of living cells through Neel relaxation of magnetic nanoparticles. Eur. Biophys. J. EBJ 37, 223–228 (2008)
Hildebrandt, B., Wust, P., Ahlers, O., Dieing, A., Sreenivasa, G., Kerner, T., Felix, R., Riess, H.: The cellular and molecular basis of hyperthermia. Crit. Rev. Oncol./Hematol. 43, 33–56 (2002)
Kozissnik, B., Bohorquez, A.C., Dobson, J., Rinaldi, C.: Magnetic fluid hyperthermia: advances, challenges, and opportunity. Int. J. Hyperth. 29, 706–714 (2013). https://doi.org/10.3109/02656736.2013.837200
Krishnan, K.M.: Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics, and therapy. IEEE Trans. Magn. 46, 2523–2558 (2010)
Brezovich, I.A., Atkinson, W.J., Lilly, M.B.: Local hyperthermia with interstitial techniques. Can. Res. 44, 4752s–4756s (1984)
Laurent, S., Dutz, S., Häfeli, U.O., Mahmoudi, M.: Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv. Coll. Interface. Sci. 166, 8–23 (2011). https://doi.org/10.1016/j.cis.2011.04.003
Dutz, S., H.R.: Magnetic nanoparticles for biomedical heating applications. Z. Phys. Chem. 220, 145 (2005)
Frey, N.A., Peng, S., Cheng, K., Sun, S.: Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem. Soc. Rev. 38, 2532 (2009). https://doi.org/10.1039/b815548h
Xu, C., Sun, S.: Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications. Dalton Trans. 5583 (2009). https://doi.org/10.1039/b900272n
Andreu, I., Natividad, E.: Accuracy of available methods for quantifying the heat power generation of nanoparticles for magnetic hyperthermia. Int. J. Hyperth. 29, 739–751 (2013)
Natividad, E., Castro, M., Mediano, A.: Adiabatic vs. non-adiabatic determination of specific absorption rate of ferrofluids. J. Mag. Magn. Mater. 321, 1497–1500 (2009). https://doi.org/10.1016/j.jmmm.2009.02.072
Pavel, M., Stancu, A.: Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy. IEEE Trans. Magn. 45, 5251–5254 (2009)
Soetaert, F., Kandala, S.K., Bakuzis, A., Ivkov, R.: Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles. Sci. Rep. 7, 6661 (2017). https://doi.org/10.1038/s41598-017-07088-w
Dennis, C.L., Ivkov, R.: Physics of heat generation using magnetic nanoparticles for hyperthermia. Int. J. Hyperth. 29, 715–729 (2013)
Bordelon, D.E., Cornejo, C., Grüttner, C., Westphal, F., DeWeese, T.L., Ivkov, R.: Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields. J. Appl. Phys. 109, 124904 (2011). https://doi.org/10.1063/1.3597820
Urtizberea, A., Natividad, E., Arizaga, A., Castro, M., Mediano, A.: Specific absorption rates and magnetic properties of ferrofluids with interaction effects at low concentrations. J. Phys. Chem. C 114, 4916–4922 (2010). https://doi.org/10.1021/jp912076f
Branquinho, L.C., Carrião, M.S., Costa, A.S., Zufelato, N., Sousa, M.H., Miotto, R., Ivkov, R., Bakuzis, A.F.: Effect of magnetic dipolar interactions on nanoparticle heating efficiency: Implications for cancer hyperthermia. Sci. Rep. 3, 2887 (2013)
Sun, S., Zeng, H., Robinson, D.B., Raoux, S., Rice, P.M., Wang, S.X., Li, G.: Monodisperse MFe2O4 (M = Fe Co, Mn) Nanoparticles. J. Am. Chem. Soc. 126, 273–279 (2003). https://doi.org/10.1021/ja0380852
Ghasemi, E., Mirhabibi, A., Edrissi, M.: Synthesis and rheological properties of an iron oxide ferrofluid. J. Magn. Magn. Mater. 320, 2635–2639 (2008). https://doi.org/10.1016/j.jmmm.2008.05.036
Mariano, R.N., Alberti, D., Cutrin, J.C., Geninatti Crich, S., Aime, S.: Design of PLGA based nanoparticles for imaging guided applications. Mol. Pharm. 11, 4100–4106 (2014). https://doi.org/10.1021/mp5002747
Ruggiero, M.R., Crich, S.G., Sieni, E., Sgarbossa, P., Forzan, M., Cavallari, E., Stefania, R., Dughiero, F., Aime, S.: Magnetic hyperthermia efficiency and 1H-NMR relaxation properties of iron oxide/paclitaxel-loaded PLGA nanoparticles. Nanotechnology 27, 285104 (2016). https://doi.org/10.1088/0957-4484/27/28/285104
Bertani, R., Ceretta, F., Barba, P.D., Dughiero, F., Forzan, M., Michelin, R.A., Sgarbossa, P., Sieni, E., Spizzo, F.: Optimal inductor design for nanofluid heating characterisation. Eng. Comput. 32, 1870–1892 (2015). https://doi.org/10.1108/EC-10-2014-0218
Di Barba, P.D., Dughiero, F., Sieni, E.: Magnetic field synthesis in the design of inductors for magnetic fluid hyperthermia. IEEE Trans. Magn. 46, 2931–2934 (2010)
Del Bianco, L., Spizzo, F., Sgarbossa, P., Sieni, E., Barucca, G., Ruggiero, M.R., Geninatti Crich, S.: Dipolar magnetic interactions in mn-doped magnetite nanoparticles loaded into PLGA nanocapsules for nanomedicine applications. J. Phys. Chem. C 123, 30007–30020 (2019). https://doi.org/10.1021/acs.jpcc.9b09146
Acknowledgements
Roberta Bertani and Mirto Mozzon wish to thank the TWINNING-2017 research project of the Industrial Engineering Department (University of Padova) for the financial support. The research was made possible thanks to the networking of the COST action CA17115 - European network for advancing Electromagnetic hyperthermic medical technologies action (www.um.edu.mt/projects/mywave/).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Sgarbossa, P. et al. (2021). Biomedical Application of Fe-Mn Oxide Nanoparticles. In: Jarm, T., Cvetkoska, A., Mahnič-Kalamiza, S., Miklavcic, D. (eds) 8th European Medical and Biological Engineering Conference. EMBEC 2020. IFMBE Proceedings, vol 80. Springer, Cham. https://doi.org/10.1007/978-3-030-64610-3_23
Download citation
DOI: https://doi.org/10.1007/978-3-030-64610-3_23
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-64609-7
Online ISBN: 978-3-030-64610-3
eBook Packages: EngineeringEngineering (R0)