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The Complex and Integral Roles of Pericytes Within the Neurovascular Unit in Health and Disease

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Biology of Pericytes – Recent Advances

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL,volume 68))

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Abbreviations

20-HETE:

20-hydroxyeicosatetraenoic acid

Aβ:

amyloid beta

AD :

Alzheimer’s disease

ALS :

amyotrophic lateral sclerosis

ApoE:

apolipoprotein E

α-SMA:

alpha-smooth muscle actin

ATP:

adenosine triphosphate

BBB :

blood-brain barrier

BOLD:

blood oxygen level dependent

CADASIL:

cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

CNS:

central nervous system

COX:

cyclooxygenase

CSF:

cerebrospinal fluid

DTA:

diptheria toxin A

fMRI:

functional magnetic resonance imaging

ICAM:

intracellular adhesion molecule

iDTR:

Cre-dependent human diptheria toxin receptor

IgG:

immunoglobulin G

IL:

interleukin

LRP-1:

low density lipoprotein receptor-related protein 1

MHC:

major histocompatibility complex

MMP9:

matrix metalloprotease 9

MS :

multiple sclerosis

NADPH:

nicotinamide adenine dinucleotide phosphate

NF-κB:

nuclear factor-kappa B

NO:

nitric oxide

NOX4:

nicotinamide adenine dinucleotide phosphate oxidase 4

NVU :

neurovascular unit

OPC:

oligodendrocyte precursor cell

PDGF-BB:

platelet-derived growth factor-BB

PDGFRβ:

platelet-derived growth factor receptor beta

PGE2:

prostaglandin E2

sPDGFRβ:

soluble platelet-derived growth factor receptor beta

TGFβ:

transforming growth factor beta

TGFβR2:

transforming growth factor beta receptor 2

TNFα:

tumor necrosis factor alpha

VCAM:

vascular cell adhesion molecule

VEGF:

vascular endothelial growth factor

VEGFR2:

vascular endothelial growth factor receptor 2

VSMC:

vascular smooth muscle cell

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Acknowledgements

I would like to acknowledge the assistance of Dr. Jo-Maree Courtney in figure generation and Drs Jo-Maree Courtney and Gary Morris for constructive feedback on the chapter.

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This article does not contain any studies with human participants or animals performed by the author.

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The author declares he has no conflict of interest.

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BAS receives funding from the National Health and Medical Research Council (APP1137776, APP1163384) and the Rebecca L. Cooper Foundation.

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  1. Medical Sciences, Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia

    Brad A. Sutherland

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  1. Columbia Univ Med Cent, Dept. Radiology, Univ Federal de Minas Gerais, Dept Patho, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Sutherland, B.A. (2021). The Complex and Integral Roles of Pericytes Within the Neurovascular Unit in Health and Disease. In: Birbrair, A. (eds) Biology of Pericytes – Recent Advances. Stem Cell Biology and Regenerative Medicine, vol 68. Humana, Cham. https://doi.org/10.1007/978-3-030-62129-2_2

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