Skip to main content
SpringerLink
Log in

Role of Metastasectomy in Prostate Cancer Patients Following Primary Treatment

  • Chapter
  • First Online:
Salvage Therapy for Prostate Cancer

  • 363 Accesses

Abstract

Metastasis-directed therapy (MDT) has been proposed as a therapeutic option in oligometastatic PCa patients, in order to delay palliative systemic treatment or even to attain cure in selected patients. This chapter examines the role of metastasectomy after primary treatment failure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Roehl KA, Han M, Ramos CG, Ann JO, Antenor V, Catalona WJ. Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol. 2004;172:910–4.

    Article  PubMed  Google Scholar 

  2. Kupelian PA, Mahadevan A, Reddy CA, Reuther AM, Klein EA, Kupelian P. Use of different definitions of biochemical failure after external beam radiotherapy changes conclusions about relative treatment efficacy for localized prostate cancer. Urology. 2006;68(3):593–8.

    Article  PubMed  Google Scholar 

  3. Freedland SJ, Humphreys EB, Mangold LA, Eisenberger M, Dorey FJ, Walsh PC, et al. Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. J Urol. 2006 Feb 1;175(2):564.

    Article  Google Scholar 

  4. Cornford P, Bellmunt J, Bolla M, Briers E, De Santis M, Gross T, et al. EAU-ESTRO-SIOG guidelines on prostate cancer. Part II: treatment of relapsing, metastatic, and castration-resistant prostate Cancer. Eur Urol. 2017 Apr;71(4):630–42.

    Article  PubMed  Google Scholar 

  5. Devos G, De Meerleer G, Joniau S. Have we entered the era of imaging before salvage treatment for recurrent prostate cancer? Eur Urol. 2019 Apr 25;

    Google Scholar 

  6. Kane CJ, Amling CL, Johnstone PA, Pak N, Lance RS, Thrasher JB, et al. Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. Urology. 2003 Mar 1;61(3):607–11.

    Article  PubMed  Google Scholar 

  7. Calais J, Czernin J, Cao M, Kishan AU, Hegde JV, Shaverdian N, et al. 68Ga-PSMA-11 PET/CT mapping of prostate Cancer biochemical recurrence after radical prostatectomy in 270 patients with a PSA level of less than 1.0 ng/mL: impact on salvage radiotherapy planning. J Nucl Med. 2018 Feb;59(2):230–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Grubmüller B, Baltzer P, D’andrea D, Korn S, Haug AR, Hacker M, et al. 68Ga-PSMA 11 ligand PET imaging in patients with biochemical recurrence after radical prostatectomy—diagnostic performance and impact on therapeutic decision-making. Eur J Nucl Med Mol Imaging. 2018;45:235–42.

    Article  PubMed  CAS  Google Scholar 

  9. Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams JP, et al. Is there a favorable subset of patients with prostate cancer who develop oligometastases? Int J Radiat Oncol. 2004 Jan 1;58(1):3–10.

    Article  Google Scholar 

  10. Ost P, Decaestecker K, Lambert B, Fonteyne V, Delrue L, Lumen N, et al. Prognostic factors influencing prostate cancer-specific survival in non-castrate patients with metastatic prostate cancer. Prostate. 2014 Feb;74(3):297–305.

    Article  CAS  PubMed  Google Scholar 

  11. Niibe Y, Hayakawa K. Oligometastases and oligo-recurrence: the new era of cancer therapy. Jpn J Clin Oncol. 2010 Feb;40(2):107–11.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Tosoian JJ, Gorin MA, Ross AE, Pienta KJ, Tran PT, Schaeffer EM. Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations HHS public access. Nat Rev Urol. 2017;14(1):15–25.

    Article  CAS  PubMed  Google Scholar 

  13. Hellman S, Weichselbaum RR. Oligometastases. J Clin Oncol. 1995 Jan 21;13(1):8–10.

    Article  CAS  PubMed  Google Scholar 

  14. Gundem G, Van Loo P, Kremeyer B, Alexandrov LB, Tubio JMC, Papaemmanuil E, et al. The evolutionary history of lethal metastatic prostate cancer. Nature. 2015 Apr 16;520(7547):353–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Weichselbaum RR, Hellman S. Oligometastases revisited. Nat Rev Clin Oncol. 2011 Jun 22;8(6):378–82.

    Article  CAS  PubMed  Google Scholar 

  16. Lussier YA, Xing HR, Salama JK, et al. MicroRNA expression characterizes oligometastasis(es). PLoS One. 2011;6(12):e28650.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ost P, Reynders D, Decaestecker K, Fonteyne V, Lumen N, De Bruycker A, et al. Surveillance or metastasis-directed therapy for Oligometastatic prostate cancer recurrence: a prospective, randomized, Multicenter phase II trial. J Clin Oncol. 2018 Feb 10;36(5):446–53.

    Article  CAS  PubMed  Google Scholar 

  18. Siva S, Bressel M, Murphy DG, Shaw M, Chander S, Violet J, et al. Stereotactic Abative body radiotherapy (SABR) for Oligometastatic prostate cancer: a prospective clinical trial. Eur Urol. 2018 Oct;74(4):455–62.

    Article  PubMed  Google Scholar 

  19. Ampollini L, Gnetti L, Goldoni M, Viani L, Faedda E, Campanini N, et al. Pulmonary metastasectomy for colorectal cancer: analysis of prognostic factors affecting survival. J Thorac Dis. 2017 Oct;9(Suppl 12):S1282–90.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Ouzaid I, Capitanio U, Staehler M, Wood CG, Leibovich BC, Ljungberg B, et al. Surgical metastasectomy in renal cell carcinoma: a systematic review. Eur Urol Oncol. 2018 Sep;0(0)

    Google Scholar 

  21. Ploussard G, Gandaglia G, Borgmann H, de Visschere P, Heidegger I, Kretschmer A, et al. Salvage lymph node dissection for nodal recurrent prostate cancer: a systematic review. Eur Urol. 2018 Oct 31;0(0)

    Google Scholar 

  22. Herlemann A, Kretschmer A, Buchner A, Karl A, Tritschler S, El-Malazi L, et al. Salvage lymph node dissection after 68 Ga-PSMA or 18 F-FEC PET/CT for nodal recurrence in prostate cancer patients. Oncotarget. 2017;8(48):84180–92.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Montorsi F, Gandaglia G, Fossati N, Suardi N, Pultrone C, De Groote R, et al. Surgery in motion robot-assisted salvage lymph node dissection for clinically recurrent prostate Cancer. 2017

    Google Scholar 

  24. Abreu A, Fay C, Park D, Quinn D, Dorff T, Carpten J, et al. Robotic salvage retroperitoneal and pelvic lymph node dissection for ‘node-only’ recurrent prostate cancer: technique and initial series. BJU Int. 2017;120(3):401–8.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Devos G, Muilwijk T, Raskin Y, Calderon V, Moris L, Van den Broeck T, et al. Comparison of Peri-operative and early oncological outcomes of robot-assisted vs. Open Salvage Lymph Node Dissection in Recurrent Prostate Cancer Front Oncol. 2019;9:781.

    PubMed  Google Scholar 

  26. Fossati N, Suardi N, Gandaglia G, Bravi CA, Soligo M, Karnes RJ, et al. Identifying the optimal candidate for salvage lymph node dissection for nodal recurrence of prostate cancer: results from a large. Multi-institutional Anal Eur Urol. 2019 Jan 1;75(1):176–83.

    Google Scholar 

  27. Battaglia A, Devos G, Decaestecker K, Witters M, Moris L, Van den Broeck T, et al. Metastasectomy for visceral and skeletal oligorecurrent prostate cancer. World J Urol. 2019 Mar;12:1–7.

    Google Scholar 

  28. Weiss RJ, Forsberg JA, Wedin R. Surgery of skeletal metastases in 306 patients with prostate cancer. Acta Orthop. 2012 Feb;83(1):74–9.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Sanjurjo S, Hamida W, Letesson G, Hustinx R, Gillet P, Andrianne R. Repérage scintigraphique peropératoire d’une métastase costale unique d’un adénocarcinome prostatique opéré. Prog Urol. 2008 Jun;18(6):402–5.

    Article  CAS  PubMed  Google Scholar 

  30. Bubendorf L, Schöpfer A, Wagner U, Sauter G, Moch H, Willi N, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000;31(5):578–83.

    Article  CAS  PubMed  Google Scholar 

  31. Gandaglia G, Karakiewicz PI, Briganti A, Passoni M, Schiffmann J, Trudeau V, et al. Impact of the site of metastases on survival in patients with metastatic prostate cancer. Eur Urol. 2015;68:325–34.

    Article  PubMed  Google Scholar 

  32. Smith CP, Sharma A, Ayala G, Cagle P, Kadmon D. Solitary pulmonary metastasis from prostate cancer. J Urol. 1999 Dec;162(6):2102.

    Article  CAS  PubMed  Google Scholar 

  33. Maebayashi T, Abe K, Aizawa T, Sakaguchi M, Ishibash N, Fukushima S, et al. Solitary pulmonary metastasis from prostate cancer with neuroendocrine differentiation: a case report and review of relevant cases from the literature. World J Surg Oncol. 2015 May 7;13(1)

    Google Scholar 

  34. Gago JP, Câmara G, Dionísio J, Opinião A. Pulmonary metastasis as sole manifestation of relapse in previously treated localised prostate cancer: three exceptional case reports. Ecancermedicalscience. 2016 Jun 7;10

    Google Scholar 

  35. Chao DH, Higgins JPT, Brooks JD. Biochemical remission after resection of prostate cancer lung metastasis. Urology. 2004;63(3):584–5.

    Article  PubMed  Google Scholar 

  36. Ciriaco P, Briganti A, Bernabei A, Gandaglia G, Carretta A, Viola C, et al. Safety and early oncologic outcomes of lung resection in patients with isolated pulmonary recurrent prostate Cancer: a single-center experience. Eur Urol. 2019;75(5):871–4.

    Article  PubMed  Google Scholar 

  37. Wang H, Li B, Zhang P, Yao Y, Chang J. Clinical characteristics and prognostic factors of prostate cancer with liver metastases.

    Google Scholar 

  38. Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh T. Metastatic patterns of prostatic cancer: correlation between sites and number of organs involved. Cancer. 1984 Dec 15;54(12):3078–84.

    Article  CAS  PubMed  Google Scholar 

  39. Wang SC, McCarthy LP, Mehdi S. Isolated hepatic metastasis from prostate carcinoma. Urol Case Rep. 2017 Jan 1;10:51.

    Article  PubMed  Google Scholar 

  40. Kawai H, Shiba H, Kanehira M, Sakamoto T, Furukawa K, Yanaga K. Successful resection of a solitary metastatic liver tumor from prostate cancer 15 years after radical prostatectomy: a case report. Surg Case Rep. 2017 Dec;3(1)

    Google Scholar 

  41. Dutt N, Bates AW, Baithun SI. Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children. Histopathology. 2000;37(4):323–31.

    Article  CAS  PubMed  Google Scholar 

  42. Price EB, Mostofi FK. Secondary carcinoma of the testis. Cancer. 1957 May;10(3):592–5.

    Article  PubMed  Google Scholar 

  43. Howard DE, Hicks WK, Scheldrup EW. Carcinoma of the prostate with simultaneous bilateral testicular metastases: case report with special study of routes of metastases. J Urol. 1957 Jul;78(1):58–64.

    Article  CAS  PubMed  Google Scholar 

  44. Patel SR, Richardson RL, Kvols L. Metastatic cancer to the testes: a report of 20 cases and review of the literature. J Urol. 1989 Oct;142(4):1003–5.

    Article  CAS  PubMed  Google Scholar 

  45. Campara Z, Simic D, Aleksic P, Spasic A, Milicevic S. Metastasis of prostate adenocarcinoma to the testis. Med Arch (Sarajevo, Bosnia Herzegovina). 2016 Jul 27;70(4):318–20.

    Google Scholar 

  46. Gibas A, Sieczkowski M, Biernat W, Matuszewski M. Isolated testicular metastasis of prostate cancer after radical prostatectomy: case report and literature review. Urol Int. 2015 Feb 4;95(4):483–5.

    Article  PubMed  Google Scholar 

  47. Kim SO, Choi YD, Jung Il S, Oh KJ, Im CM, Kang TW, et al. Prostate cancer with solitary metastases to the bilateral testis. Yonsei Med J. 2011 Mar;52(2):362–4.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Bonetta A, Generali D, Corona SP, Cancarini G, Brenna S, Pacifico C, et al. Isolated testicular metastasis from prostate cancer. Am J Case Rep. 2017 Aug 14;18:887–9.

    Article  PubMed  PubMed Central  Google Scholar 

  49. da Cunha ML, de Oliveira Rodrigues C, de Araújo MPL, de Freitas Junior CH, Ferrigno R. Solitary testicular metastasis from prostate cancer. A case report diagnosed by PET/CT with PSMA. Vol. 45, European Journal of Nuclear Medicine and Molecular Imaging. Springer Berlin Heidelberg; 2018. p. 888–9.

    Google Scholar 

  50. Tu S-M, Reyes A, Maa A, Bhowmick D, Pisters LL, Pettaway CA, et al. Prostate carcinoma with testicular or penile metastases. Cancer. 2002 May 15;94(10):2610–7.

    Article  PubMed  Google Scholar 

  51. Van den Berg GM, Menke HE, Stolz E. Nodules on the glans penis, an unusual metastatic pattern of prostate carcinoma: case report. Genitourin Med. 1986;62(2):126–8.

    PubMed  PubMed Central  Google Scholar 

  52. Philip J, Mathew J. Penile metastasis of prostatic adenocarcinoma: report of two cases and review of literature Prostateadenocarcinomapenile metastasisquality of life. 2003.

    Google Scholar 

  53. Ciriaco P, Briganti A, Bernabei A, Gandaglia G, Carretta A, Viola C, et al. Safety and early oncologic outcomes of lung resection in patients with isolated pulmonary recurrent prostate Cancer: a single-center experience. Eur Urol. 2019 May 1;75(5):871–4.

    Article  PubMed  Google Scholar 

  54. Chao DH, Higgins JPT, Brooks JD. Biochemical remission after resection of prostate cancer lung metastasis. Urology. 2004;63(3):584–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departement of Urology, University Hospitals Leuven, Leuven, Belgium

    Gaëtan Devos, Antonino Battaglia, Lorenzo Tosco, Wouter Everaerts, Maarten Albersen, Hendrik Van Poppel & Steven Joniau

  2. Departement of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium

    Charlien Berghen & Gert De Meerleer

Authors
  1. Gaëtan Devos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonino Battaglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lorenzo Tosco
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wouter Everaerts
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charlien Berghen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maarten Albersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gert De Meerleer
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hendrik Van Poppel
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Steven Joniau
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gaëtan Devos .

Editor information

Editors and Affiliations

  1. Southend University Hospital NHS Foundation Trust, Southend, UK

    Sanchia S. Goonewardene

  2. North Bristol NHS Foundation Trust, Bristol, UK

    Raj Persad

  3. Harvard University, Boston, MA, USA

    Karen Ventii

  4. Department of Urology, Crouse Hospital, Syracuse, NY, USA

    David Albala

  5. Royal Marsden Hospital, London, UK

    Declan Cahill

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Devos, G. et al. (2021). Role of Metastasectomy in Prostate Cancer Patients Following Primary Treatment. In: Goonewardene, S.S., Persad, R., Ventii, K., Albala, D., Cahill, D. (eds) Salvage Therapy for Prostate Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-57181-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-57181-8_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-57180-1

  • Online ISBN: 978-3-030-57181-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation