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Stem Cell Therapy Delivery in Liver Disease

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Stem Cell Therapy for Vascular Diseases

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Abstract

Among visceral organs, the liver is unique in its resilience to severe injury. Even after removal of up to 75% of total liver mass, an otherwise healthy liver can regrow to a fully functioning state within a few weeks. However, this capacity is not without its limits, and the regenerative potential can become exhausted in cases of chronic injury leading to fibrotic scarring and eventually cirrhosis. Currently, transplant is the only curative therapy for cirrhosis, but a severe organ shortage limits access to this treatment. Thus, there is an urgent unmet need for therapeutics that can prevent, slow, or reverse fibrotic scarring in the liver. Stem cell therapy has emerged as a promising modality to meet this unmet need by augmenting the liver’s natural repair processes. However, realizing this potential will require addressing three key challenges delineated in this chapter: (1) identifying the most effective stem cell type(s), (2) determining the impact of liver disease etiology, and (3) optimization of route and timing of delivery to ensure maximal therapeutic benefit.

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Authors and Affiliations

  1. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA

    John Langford & Gregory T. Tietjen

  2. Department of Biomedical Engineering, Yale University, New Haven, CT, USA

    Gregory T. Tietjen

  3. Department of Surgery – Transplant Section, Yale School of Medicine, New Haven, CT, USA

    Gregory T. Tietjen

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  1. John Langford
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  2. Gregory T. Tietjen
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Correspondence to Gregory T. Tietjen .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Langford, J., Tietjen, G.T. (2021). Stem Cell Therapy Delivery in Liver Disease. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_18

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