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Nephrology in South Africa

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Nephrology Worldwide

Abstract

An epidemic of acute and chronic kidney disease is being experienced in South Africa. This is driven by a heavy burden of infections, non-communicable disease, pregnancy-related disease and injuries. Competing priorities such as the high burden of HIV, tuberculosis and other infections, unemployment and poverty result in serious constraints to providing comprehensive kidney care, especially in the public healthcare sector which serves most of the population.

Nephrology is a well-developed discipline in South Africa, with good sub-speciality training programmes and strong national organizations such as the South African Renal Society, National Kidney Foundation of South Africa and South African Transplantation Society.

South Africa has contributed to African nephrology through the training of nephrology fellows from various African countries, through editorial roles on the African Journal of Nephrology and, more recently, by providing the platform for the African Renal Registry. On the global front, South African nephrologists have played leadership roles in the International Society of Nephrology and other organizations, and have led or contributed to the development of international nephrology guidelines.

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References

  1. Mid-year population estimates, 2018. Pretoria: Statistics South Africa; 2018.

    Google Scholar 

  2. General household survey, 2018. Pretoria: Statistics South Africa; 2019.

    Google Scholar 

  3. South Africa overview. Washington, DC: The World Bank; 2019.

    Google Scholar 

  4. Council for Medical Schemes Annual Report 2017/18. Pretoria: Council for Medical Schemes; 2018.

    Google Scholar 

  5. Marquez PV, Farrington JL. The challenge of non-communicable diseases and road traffic injuries in Sub-Saharan Africa: an overview. Washington, DC: The World Bank; 2013.

    Google Scholar 

  6. Noncommunicable diseases among young people in Africa. Washington, DC: Population Reference Bureau; 2015.

    Google Scholar 

  7. Sekokotla MA, Goswami N, Sewani-Rusike CR, Iputo JE, Nkeh-Chungag BN. Prevalence of metabolic syndrome in adolescents living in Mthatha, South Africa. Ther Clin Risk Manag. 2017;13:131–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mayosi BM, Flisher AJ, Lalloo UG, Sitas F, Tollman SM, Bradshaw D. The burden of non-communicable diseases in South Africa. Lancet. 2009;374:934–47.

    Article  PubMed  Google Scholar 

  9. Keene R. Our graduates 1924–2012. Johannesburg: Adler Museum of Medicine, Faculty of Health Sciences, University of the Witwatersrand; 2013.

    Google Scholar 

  10. Wearne N, Okpechi IG, Swanepoel CR. Nephrology in South Africa: not yet Ubuntu. Kidney Dis. 2019;5:189–96.

    Article  Google Scholar 

  11. Fabian J, Maher H, Bentley A, Gaylard P, Crymble K, Rossi B, et al. Favourable outcomes for the first 10 years of kidney and pancreas transplantation at Wits Donald Gordon Medical Centre, Johannesburg, South Africa. S Afr Med J. 2016;106:172–6.

    Article  PubMed  Google Scholar 

  12. Friedericksen DV, Van der Merwe L, Hattingh TL, Nel DG, Moosa MR. Acute renal failure in the medical ICU still predictive of high mortality. S Afr Med J. 2009;99:873–5.

    CAS  PubMed  Google Scholar 

  13. Dlamini TAL, Heering PJ, Chivese T, Rayner B. A prospective study of the demographics, management and outcome of patients with acute kidney injury in Cape Town, South Africa. PLoS One. 2017;12:e0177460.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Camara SN, Chothia M-Y. Outcomes of critically ill adult patients with continuous renal replacement therapy-requiring acute kidney injury in the Free State province of South Africa: the impact of HIV. Afr J Nephrol. 2017;20:39–44.

    Google Scholar 

  15. Variava M, Mashabane M, Bentley A, Naicker S. Epidemiology and outcomes of dialysis-requiring acute kidney injury at Chris Hani Baragwanath Hospital. Wits J Clin Med. 2019;1:31–6.

    Google Scholar 

  16. Wyatt CM, Arons RR, Klotman PE, Klotman ME. Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality. AIDS. 2006;20:561–5.

    Article  PubMed  Google Scholar 

  17. Gerntholtz TE, Goetsch SJ, Katz I. HIV-related nephropathy: a South African perspective. Kidney Int. 2006;69:1885–91.

    Article  CAS  PubMed  Google Scholar 

  18. Wearne N, Swanepoel CR, Boulle A, Duffield MS, Rayner BL. The spectrum of renal histologies seen in HIV with outcomes, prognostic indicators and clinical correlations. Nephrol Dial Transplant. 2012;27:4109–18.

    Article  PubMed  Google Scholar 

  19. Vermeulen A, Menezes C, Mashabane M, Butler O, Mosiane P, Goetsch S, et al. Patterns of renal disease: a 30-year renal biopsy study at Chris Hani Baragwanath Academic Hospital, Soweto, Johannesburg, South Africa. S Afr Med J. 2019;109:486–92.

    Article  CAS  PubMed  Google Scholar 

  20. Boswell MT, Rossouw TM. Approach to acute kidney injury in HIV-infected patients in South Africa. S Afr J HIV Med. 2017;18:a714.

    Article  Google Scholar 

  21. Seedat F, Martinson N, Motlhaoleng K, Abraham P, Mancama D, Naicker S, et al. Acute kidney injury, risk factors, and prognosis in hospitalized HIV-infected adults in South Africa, compared by tenofovir exposure. AIDS Res Hum Retrovir. 2017;33:33–40.

    Article  CAS  PubMed  Google Scholar 

  22. Vachiat AI, Musenge E, Wadee S, Naicker S. Renal failure in HIV-positive patients-a South African experience. Clin Kidney J. 2013;6:584–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Arendse C, Okpechi I, Swanepoel C. Acute dialysis in HIV-positive patients in Cape Town, South Africa. Nephrology. 2011;16:39–44.

    Article  PubMed  Google Scholar 

  24. Chothia M-Y, Ramsunder N. In-hospital mortality of HIV-positive patients with acute kidney injury a decade after the roll-out of anti-retroviral therapy in Cape Town, South Africa. Afr J Nephrol. 2019;22:46–53.

    Google Scholar 

  25. Stanifer JW, Kilonzo K, Wang D, Su G, Mao W, Zhang L, et al. Traditional medicines and kidney disease in low-and middle-income countries: opportunities and challenges. Semin Nephrol. 2017;37:245–59.

    Article  PubMed  Google Scholar 

  26. Luyckx VA. Nephrotoxicity of alternative medicine practice. Adv Chronic Kidney Dis. 2012;19:129–41.

    Article  PubMed  Google Scholar 

  27. Ashuntantang G, Osafo C, Olowu WA, Arogundade F, Niang A, Porter J, et al. Outcomes in adults and children with end-stage kidney disease requiring dialysis in Sub-Saharan Africa: a systematic review. Lancet Glob Health. 2017;5:e408–17.

    Article  PubMed  Google Scholar 

  28. Dunn J, Krige J, Wood R, Bornman P, Terblanche J. Colonic complications after toxic tribal enemas. Br J Surg. 1991;78:545–8.

    Article  CAS  PubMed  Google Scholar 

  29. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis. 2002;39:E13.11–5.

    Article  Google Scholar 

  30. Müller G, Modler H, Wium C, Veale D, Marks C. Snake bite in southern Africa: diagnosis and management. Contin Med Educ. 2012;30:362–82.

    Google Scholar 

  31. Coetzer P, Tilbury C. The epidemiology of snakebite in Northern Natal. S Afr Med J. 1982;62:206–12.

    CAS  PubMed  Google Scholar 

  32. Blaylock R. Epidemiology of snakebite in Eshowe, KwaZulu-Natal, South Africa. Toxicon. 2004;43:159–66.

    Article  CAS  PubMed  Google Scholar 

  33. Chippaux J-P. Estimate of the burden of snakebites in Sub-Saharan Africa: a meta-analytic approach. Toxicon. 2011;57:586–99.

    Article  CAS  PubMed  Google Scholar 

  34. Chippaux JP. Snake-bites: appraisal of the global situation. Bull World Health Organ. 1998;76:515–24.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Wood D, Sartorius B, Hift R. Snakebite in North-Eastern South Africa: clinical characteristics and risks for severity. S Afr Fam Prac. 2016;58:62–7.

    Article  Google Scholar 

  36. Müller G, Wium C, Marks C, Du Plessis C, Veale D. Spider bite in southern Africa: diagnosis and management. Contin Med Educ. 2012;30:382–92.

    Google Scholar 

  37. Muller GJ. Black and brown widow spider bites in South Africa. A series of 45 cases. S Afr Med J. 1993;83:399–405.

    CAS  PubMed  Google Scholar 

  38. Chippaux J-P, Goyffon M. Epidemiology of scorpionism: a global appraisal. Acta Trop. 2008;107:71–9.

    Article  PubMed  Google Scholar 

  39. Müller G, Modler H, Wium C, Veale D. Scorpion sting in Southern Africa: diagnosis and management. Contin Med Educ. 2012;30:356–61.

    Google Scholar 

  40. Muller GJ. Scorpionism in South Africa. A report of 42 serious scorpion envenomations. S Afr Med J. 1993;83:405–11.

    CAS  PubMed  Google Scholar 

  41. Seedat YK. Acute renal failure among Blacks and Indians in South Africa. S Afr Med J. 1978;54:427–31.

    CAS  PubMed  Google Scholar 

  42. Randeree IG, Czarnocki A, Moodley J, Seedat YK, Naiker IP. Acute renal failure in pregnancy in South Africa. Ren Fail. 1995;17:147–53.

    Article  CAS  PubMed  Google Scholar 

  43. Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Conti-Ramsden F, et al. Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa: a prospective cohort study. J Glob Health. 2018;8:020401.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Makhanya V, Moodley J, Govender L. Eclampsia: still a major problem in rural KwaZulu-Natal Province, South Africa. S Afr J Obstet Gynaecol. 2016;22:13–7.

    Article  Google Scholar 

  45. Bouwer F, Langenegger E, Moosa MR. Comparison of the outcome of patients with acute renal failure as a complication of HELLP syndrome before and after 36 weeks gestation. MMed thesis. Cape Town: Stellenbosch University; 2013.

    Google Scholar 

  46. Smoyer WE, Finkelstein FO, McCulloch MI, Carter M, Brusselmans A, Feehally J. “Saving Young Lives” with acute kidney injury: the challenge of acute dialysis in low-resource settings. Kidney Int. 2016;89:254–6.

    Article  PubMed  Google Scholar 

  47. Abdou N, Antwi S, Koffi LA, Lalya F, Adabayeri VM, Nyah N, et al. Peritoneal dialysis to treat patients with acute kidney injury-the Saving Young Lives experience in West Africa: proceedings of the Saving Young Lives session at the First International Conference of Dialysis in West Africa, Dakar, Senegal, December 2015. Perit Dial Int. 2017;37:155–8.

    Article  PubMed  Google Scholar 

  48. Smoyer WE, Finkelstein FO, McCulloch M, Carter M, Brusselmans A, Feehally J. Saving Young Lives: provision of acute dialysis in low-resource settings. Lancet. 2015;386:2056.

    Article  PubMed  Google Scholar 

  49. van Deventer HE, George JA, Paiker JE, Becker PJ, Katz IJ. Estimating glomerular filtration rate in black South Africans by use of the Modification of Diet in Renal Disease and Cockcroft-Gault equations. Clin Chem. 2008;54:1197–202.

    Google Scholar 

  50. Madala ND, Nkwanyana N, Dubula T, Naiker IP. Predictive performance of eGFR equations in South Africans of African and Indian ancestry compared with 99mTc-DTPA imaging. Int Urol Nephrol. 2012;44:847–55.

    Article  PubMed  Google Scholar 

  51. Moodley N, Hariparshad S, Peer F, Gounden V. Evaluation of the CKD-EPI creatinine based glomerular filtration rate estimating equation in Black African and Indian adults in KwaZulu-Natal, South Africa. Clin Biochem. 2018;59:43–9.

    Article  CAS  PubMed  Google Scholar 

  52. Holness JL, Bezuidenhout K, Davids MR, Warwick JM. Validation of equations to estimate glomerular filtration rate in South Africans of mixed ancestry. S Afr Med J. 2020;110(3):229–34.

    Article  CAS  PubMed  Google Scholar 

  53. Matsha TE, Yako YY, Rensburg MA, Hassan MS, Kengne AP, Erasmus RT. Chronic kidney diseases in mixed ancestry South African populations: prevalence, determinants and concordance between kidney function estimators. BMC Nephrol. 2013;14:75.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Adeniyi AB, Laurence CE, Volmink JA, Davids MR. Prevalence of chronic kidney disease and association with cardiovascular risk factors among teachers in Cape Town, South Africa. Clin Kidney J. 2017;10:363–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Elamin S, Obeid W, Abu-Aisha H. Renal replacement therapy in Sudan, 2009. Arab J Nephrol Transplant. 2010;3:31–6.

    Google Scholar 

  56. Rapport D’Activite Des Centres et Unites D’Hemodialyse, Annee 2010. Ministere de la Sante Publique, Tunisia, 2011.

    Google Scholar 

  57. Insuffisance rénale chronique terminale. Moroccan Society of Nephrology and Moroccan Ministry of Health, 2013.

    Google Scholar 

  58. Keeton G, van Zyl SR, Bryer A. Renal outcome of type 2 diabetes in South Africa—a 12-year follow-up study. J Endocrinol Metab Diabetes S Afr. 2004;9:84–8.

    Google Scholar 

  59. Gill GV, Huddle KR, Monkoe G. Long-term (20 years) outcome and mortality of Type 1 diabetic patients in Soweto, South Africa. Diabet Med. 2005;22:1642–6.

    Article  CAS  PubMed  Google Scholar 

  60. Davids MR, Jardine T, Marais N, Zunza M, Jacobs JC, Sebastian S. South African Renal Registry Annual Report 2017. Afr J Nephrol. 2019;22:60–71.

    Google Scholar 

  61. Patchapen Y. A retrospective study evaluating the patterns of primary glomerular disease at Charlotte Maxeke Johannesburg Academic Hospital. MMed thesis. Johannesburg: University of the Witwatersrand; 2017.

    Google Scholar 

  62. Okpechi I, Swanepoel C, Duffield M, Mahala B, Wearne N, Alagbe S, et al. Patterns of renal disease in Cape Town South Africa: a 10-year review of a single-centre renal biopsy database. Nephrol Dial Transplant. 2011;26:1853–61.

    Article  PubMed  Google Scholar 

  63. Esmail A, Amirali MH, Jardine T, Bates WD, Davids MR. Patterns of biopsy-proven renal disease in Cape Town, South Africa, from 1995 to 2017. MMed thesis. Cape Town: Stellenbosch University; 2019.

    Google Scholar 

  64. Tannor E, Bates W, Moosa M. The clinical relevance of repeat renal biopsies in the management of lupus nephritis: a South African experience. Lupus. 2018;27(4):525–35.

    Article  CAS  PubMed  Google Scholar 

  65. Rao TK, Filippone EJ, Nicastri AD, Landesman SH, Frank E, Chen CK, et al. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med. 1984;310:669–73.

    Article  CAS  PubMed  Google Scholar 

  66. Pardo V, Aldana M, Colton RM, Fischl MA, Jaffe D, Moskowitz L, et al. Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:429–34.

    Article  CAS  PubMed  Google Scholar 

  67. Gardenswartz MH, Lerner CW, Seligson GR, Zabetakis PM, Rotterdam H, Tapper ML, et al. Renal disease in patients with AIDS: a clinicopathologic study. Clin Nephrol. 1984;21:197–204.

    CAS  PubMed  Google Scholar 

  68. Bates WD, Muller N, van de Wal BW, Jacobs JC. HIV-associated nephropathy-an initial presentation in an HIV-positive patient. S Afr Med J. 1994;84:223–4.

    CAS  PubMed  Google Scholar 

  69. Rosenberg AZ, Naicker S, Winkler CA, Kopp JB. HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment. Nat Rev Nephrol. 2015;11:150–60.

    Article  CAS  PubMed  Google Scholar 

  70. Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol. 2011;22:2129–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Kasembeli AN, Duarte R, Ramsay M, Mosiane P, Dickens C, Dix-Peek T, et al. APOL1 risk variants are strongly associated with HIV-associated nephropathy in black South Africans. J Am Soc Nephrol. 2015;26(11):2882–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Han TM, Naicker S, Ramdial PK, Assounga AG. A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa. Kidney Int. 2006;69:2243–50.

    Article  CAS  PubMed  Google Scholar 

  73. Szczech LA, Gupta SK, Habash R, Guasch A, Kalayjian R, Appel R, et al. The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection. Kidney Int. 2004;66:1145–52.

    Article  PubMed  Google Scholar 

  74. Fabian J, Naicker S, Goetsch S, Venter WD. The clinical and histological response of HIV-associated kidney disease to antiretroviral therapy in South Africans. Nephrol Dial Transplant. 2013;28:1543–54.

    Article  CAS  PubMed  Google Scholar 

  75. Yahaya I, Uthman OA, Uthman MMB. Interventions for HIV-associated nephropathy. Cochrane Database Syst Rev. 2009;4:CD007183.

    Google Scholar 

  76. Wearne N, Swanepoel CR, Duffield MS, Davidson BJ, Manning K, Tiffin N, et al. The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa. BMC Nephrol. 2019;20:44.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Bates WD. Hepatitis-B-associated glomerular disease: a clinicopathological study of hepatitis B virus associated membranous glomerulonephritis in Namibian and South African children 1974–2005 and a comparison with hepatitis B associated membranous glomerulonephritis as well as idiopathic membranous glomerulonephritis in adults. PhD thesis, Cape Town: Stellenbosch University; 2011.

    Google Scholar 

  78. Bhimma R, Coovadia HM, Adhikari M, Connolly CA. The impact of the hepatitis B virus vaccine on the incidence of hepatitis B virus-associated membranous nephropathy. Arch Pediatr Adolesc Med. 2003;157:1025–30.

    Article  PubMed  Google Scholar 

  79. Gold CH, Isaacson C, Levin J. The pathological basis of end-stage renal disease in blacks. S Afr Med J. 1982;61:263–5.

    CAS  PubMed  Google Scholar 

  80. Freedman BI, Murea M. Target organ damage in African American hypertension: role of APOL1. Curr Hypertens Rep. 2012;14:21–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Perneger TV, Whelton PK, Klag MJ, Rossiter KA. Diagnosis of hypertensive end-stage renal disease: effect of patient’s race. Am J Epidemiol. 1995;141:10–5.

    Article  CAS  PubMed  Google Scholar 

  82. Schlessinger SD, Tankersley MR, Curtis JJ. Clinical documentation of end-stage renal disease due to hypertension. Am J Kidney Dis. 1994;23:655–60.

    Article  CAS  PubMed  Google Scholar 

  83. Lombard EH, Kromberg JG, Thomson PD, Milner LS, van Biljon I, Jenkins T. Autosomal recessive polycystic kidney disease. Evidence for high frequency of the gene in the Afrikaans-speaking population. S Afr Med J. 1989;76:321–3.

    CAS  PubMed  Google Scholar 

  84. Lambie L, Amin R, Essop F, Cnaan A, Krause A, Guay-Woodford LM. Clinical and genetic characterization of a founder PKHD1 mutation in Afrikaners with ARPKD. Pediatr Nephrol. 2015;30:273–9.

    Article  PubMed  Google Scholar 

  85. van der Merwe PD, Rensburg MA, Haylett WL, Bardien S, Davids MR. Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings. BMC Nephrol. 2017;18:38.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Nkeh B, Samani NJ, Badenhorst D, Libhaber E, Sareli P, Norton GR, et al. T594M variant of the epithelial sodium channel β-subunit gene and hypertension in individuals of African ancestry in South Africa. Am J Hypertens. 2003;16:847–52.

    Article  CAS  PubMed  Google Scholar 

  87. Jones ES, Owen EP, Rayner BL. The association of the R563Q genotype of the ENaC with phenotypic variation in Southern Africa. Am J Hypertens. 2012;25:1286–91.

    CAS  PubMed  Google Scholar 

  88. Dhanjal M, Owen E, Anthony J, Davidson J, Rayner B. Association of pre-eclampsia with the R563Q mutation of the β-subunit of the epithelial sodium channel. BJOG. 2006;113:595–8.

    Article  CAS  PubMed  Google Scholar 

  89. du Toit ED, Pascoe M, MacGregor K, Thomson PD. SADTR Report 1994. Combined report on maintenance dialysis and transplantation in the Republic of South Africa. Cape Town, South Africa: South African Dialysis and Transplantation Registry; 1994.

    Google Scholar 

  90. Moosa MR, Wearne N. Invited commentary: should we be rationing dialysis in South Africa in the 21st century? Perit Dial Int. 2018;38:84–8.

    Article  PubMed  Google Scholar 

  91. Moosa MR, Maree JD, Chirehwa MT, Benatar SR. Use of the ‘Accountability for Reasonableness’ approach to improve fairness in accessing dialysis in a middle-income country. PLoS One. 2016;11:e0164201.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Kilonzo KG, Jones ES, Okpechi IG, Wearne N, Barday Z, Swanepoel CR, et al. Disparities in dialysis allocation: an audit from the new South Africa. PLoS One. 2017;12:e0176041.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Moosa MR, Meyers AM, Gottlich E, Naicker S. An effective approach to chronic kidney disease in South Africa. S Afr Med J. 2016;106:156–9.

    Article  PubMed  Google Scholar 

  94. Jardine T, Wong E, Steenkamp R, Caskey FJ, Davids MR. Survival of South African patients on renal replacement therapy. Clin Kidney J. 2020:1–9. https://doi.org/10.1093/ckj/sfaa012.

  95. Kramer A, Pippias M, Noordzij M, Stel VS, Andrusev AM, Aparicio-Madre MI, et al. The European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) Registry annual report 2016: a summary. Clin Kidney J. 2019;12:702–20.

    Article  PubMed  PubMed Central  Google Scholar 

  96. UK Renal registry 21st annual report – data to 31/12/2017. Bristol: UK Renal Registry; 2019.

    Google Scholar 

  97. Makhele L, Matlala M, Sibanda M, Martin AP, Godman B. A cost analysis of haemodialysis and peritoneal dialysis for the management of end-stage renal failure at an Academic Hospital in Pretoria, South Africa. Pharmacoecon Open. 2019;3:631–41.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Malatji ΤA, Wamukuo JΤ, Hyera F. An analysis of the direct cost of renal dialysis provided through a public-private partnership at a tertiary hospital in Limpopo Province, South Africa. S Afr Med J. 2019;109:577–81.

    Article  CAS  PubMed  Google Scholar 

  99. Davids MR, Balbir Singh GK, Marais N, Jacobs JC. South African Renal Registry Annual Report 2014. Cape Town: South African Renal Society; 2016.

    Google Scholar 

  100. Abu-Aisha H, Elamin S. Peritoneal dialysis in Africa. Perit Dial Int. 2010;30:23–8.

    Article  PubMed  Google Scholar 

  101. Davidson B, Crombie K, Manning K, Rayner B, Wearne N. Outcomes and challenges of a PD-First program, a South African perspective. Perit Dial Int. 2018;38:179–86.

    Google Scholar 

  102. Kapembwa KC, Bapoo NA, Tannor EK, Davids MR. Peritoneal dialysis technique survival at Tygerberg Hospital in Cape Town, South Africa. Afr J Nephrol. 2017;20:25–33.

    Google Scholar 

  103. Isla RAT, Mapiye D, Swanepoel CR, Rozumyk N, Hubahib JE, Okpechi IG. Continuous ambulatory peritoneal dialysis in Limpopo province, South Africa: predictors of patient and technique survival. Perit Dial Int. 2014;34:518–25.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Zent R, Myers JE, Donald D, Rayner BL. Continuous ambulatory peritoneal dialysis: an option in the developing world? Perit Dial Int. 1994;14:48–51.

    Article  CAS  PubMed  Google Scholar 

  105. de Andrade BK, Qureshi AR, Lopes AA, Fernandes N, Barbosa LM, Pecoits-Filho R, et al. Family income and survival in Brazilian Peritoneal Dialysis Multicenter Study patients (BRAZPD): time to revisit a myth? Clin J Am Soc Nephrol. 2011;6:1676–83.

    Google Scholar 

  106. Li PK, Szeto CC, Piraino B, Bernardini J, Figueiredo AE, Gupta A, et al. Peritoneal dialysis-related infections recommendations: 2010 update. Perit Dial Int. 2010;30:393–423.

    Article  PubMed  Google Scholar 

  107. Okpechi IG, Rayner BL, Swanepoel CR. Peritoneal dialysis in Cape Town, South Africa. Perit Dial Int. 2012;32:254–60.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Ndlovu KC, Assounga A. Continuous ambulatory peritoneal dialysis in patients with HIV and end-stage renal failure. Perit Dial Int. 2017;37:321–30.

    Article  PubMed  Google Scholar 

  109. Okaka EI, Naidoo S, Ahmed MM, Davies M, Naicker S. Quality of life in patients on continuous ambulatory peritoneal dialysis in an African setting. Saudi J Kidney Dis Transpl. 2015;26:631–7.

    Article  PubMed  Google Scholar 

  110. Okaka EI, Davies M, Ahmed M, Naidoo S, Naicker S. Impact of socio-economic factors on quality of life in patients on continuous ambulatory peritoneal dialysis in an African setting. West Afr J Med. 2014;33:125–9.

    CAS  PubMed  Google Scholar 

  111. Tannor EK, Archer E, Kapembwa K, Van Schalkwyk SC, Davids MR. Quality of life in patients on chronic dialysis in South Africa: a comparative mixed methods study. BMC Nephrol. 2017;18:4.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Bello AK, Levin A, Tonelli M, Okpechi IG, Feehally J, Harris D, et al. Assessment of global kidney health care status. JAMA. 2017;317:1864–81.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Muller E, Thomson D, McCurdie F. Transplantation in South Africa. Transplantation. 2015;99:643–5.

    Article  PubMed  Google Scholar 

  114. Moosa M. The state of kidney transplantation in South Africa. S Afr Med J. 2019;109:235–40.

    Article  CAS  PubMed  Google Scholar 

  115. Etheredge H, Turner R, Kahn D. Public attitudes to organ donation among a sample of urban-dwelling South African adults: a 2012 study. Clin Transpl. 2013;27:684–92.

    CAS  Google Scholar 

  116. Muller E, Barday Z, Mendelson M, Kahn D. HIV-positive–to–HIV-positive kidney transplantation—results at 3 to 5 years. N Engl J Med. 2015;372:613–20.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Davidson B, Du Toit T, Jones ES, Barday Z, Manning K, Mc Curdie F, et al. Outcomes and challenges of a kidney transplant programme at Groote Schuur Hospital, Cape Town: a South African perspective. PLoS One. 2019;14:e0211189.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Sakajiki AM, Naidoo S, Manga P, Nazir M, Naicker S. Proteinuria, graft outcomes, and cardiovascular risk among kidney transplant recipients in a South African Public Hospital. Saudi J Kidney Dis Transpl. 2016;27:1217–23.

    Google Scholar 

  119. Davids MR, Eastwood JB, Selwood NH, Arogundade FA, Ashuntantang G, Benghanem Gharbi M, et al. A renal registry for Africa: first steps. Clin Kidney J. 2016;9:162–7.

    Article  PubMed  Google Scholar 

  120. Ocheke IE, Antwi S, Gajjar P, McCulloch MI, Nourse P. Pelvi-ureteric junction obstruction at Red Cross Children’s Hospital, Cape Town: a six year review. Arab J Nephrol Transplant. 2014;7:33–6.

    PubMed  Google Scholar 

  121. Frigati L, Mahtab S, Nourse P, Ray P, Perrazzo S, Machemedze T, et al. Prevalence of risk factors for chronic kidney disease in South African youth with perinatally acquired HIV. Pediatr Nephrol. 2019;34:313–8.

    Article  PubMed  Google Scholar 

  122. Ladapo TA, Gajjar P, McCulloch M, Scott C, Numanoglu A, Nourse P. Impact of revascularization on hypertension in children with Takayasu’s arteritis-induced renal artery stenosis: a 21-year review. Pediatr Nephrol. 2015;30:1289–95.

    Article  PubMed  Google Scholar 

  123. Keenswijk W, Sinclair G, Benetton M, du Plessis M, Nourse P, Reddy D, et al. Audit of hemodialysis in children weighing less than 20 kg in an African pediatric nephrology unit. Ther Apher Dial. 2018;22:617–23.

    Article  PubMed  Google Scholar 

  124. Levy CS, Mudi A, Venter B, Geel J. Challenges facing children on chronic peritoneal dialysis in South Africa. Perit Dial Int. 2018;38:402–4.

    Article  PubMed  Google Scholar 

  125. Spearman C, McCulloch M. Challenges for paediatric transplantation in Africa. Pediatr Transplant. 2014;18:668–74.

    Article  CAS  PubMed  Google Scholar 

  126. L’Huillier AG, Green M, Danziger-Isakov L, Chaudhuri A, Höcker B, Van der Linden D, et al. Infections among pediatric transplant candidates: an approach to decision-making. Pediatr Transplant. 2019;23:e13375.

    Google Scholar 

  127. Bhimma R, Adhikari M, Asharam K, Connolly C. The spectrum of chronic kidney disease (stages 2–5) in KwaZulu-Natal, South Africa. Pediatr Nephrol. 2008;23:1841–6.

    Article  PubMed  Google Scholar 

  128. Anochie I, Eke F. Chronic renal failure in children: a report from Port Harcourt, Nigeria (1985–2000). Pediatr Nephrol. 2003;18:692–5.

    Article  PubMed  Google Scholar 

  129. ANZDATA. Paediatrics. 37th Report, Australia and New Zealand Dialysis and Transplant Registry, 2015.

    Google Scholar 

  130. Ferris ME, Gipson DS, Kimmel PL, Eggers PW. Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America. Pediatr Nephrol. 2006;21:1020–6.

    Article  PubMed  Google Scholar 

  131. UNAIDS. Fact sheet. Global statistics. http://www.unaidsorg/en/resources/campaigns/2014/2014gapreport/factsheet. Retrieved 5 June 2016.

  132. Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015;385:1975–82.

    Article  PubMed  Google Scholar 

  133. Davidson B, Okpechi I, McCulloch M, Wearne N. Adolescent nephrology: an emerging frontier for kidney care in sub-Saharan Africa. Nephrology. 2017;22:933–9.

    Article  PubMed  Google Scholar 

  134. Hassen M, Archer E, Pellizzon A, Chikte UME, Davids MR. Human resources for nephrology in South Africa: a mixed-methods study. PLoS One. 2020;15(2):e0228890.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  135. Bello A, Levin A, Lunney M, Osman M, Ye F, Ashuntantang G, et al. ISN Global Kidney Health Atlas 2019. Brussels: International Society of Nephrology; 2019.

    Google Scholar 

  136. Dirks JH, Robinson SW. The global perspective of the International Society of Nephrology: a decade of experience with COMGAN. Kidney Int. 2005;68:1395–410.

    Article  PubMed  Google Scholar 

  137. Harris DC, Dupuis S, Couser WG, Feehally J. Training nephrologists from developing countries: does it have a positive impact? Kidney Int Suppl (2011). 2012;2:275–8.

    Article  Google Scholar 

  138. Davison SN, Levin A, Moss AH, Jha V, Brown EA, Brennan F, et al. Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care. Kidney Int. 2015;88:447–59.

    Article  PubMed  Google Scholar 

  139. Swanepoel CR, Atta MG, D’Agati VD, Estrella MM, Fogo AB, Naicker S, et al. Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2018;93:545–59.

    Article  PubMed  PubMed Central  Google Scholar 

  140. Murtagh FE, Burns A, Moranne O, Morton RL, Naicker S. Supportive care: comprehensive conservative care in end-stage kidney disease. Clin J Am Soc Nephrol. 2016;11:1909–14.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Cullis B, Abdelraheem M, Abrahams G, Balbi A, Cruz DN, Frishberg Y, et al. Peritoneal dialysis for acute kidney injury. Perit Dial Int. 2014;34:494–517.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Davids MR, Edoute Y, Jungas RL, Cheema-Dhadli S, Halperin ML. Facilitating an understanding of integrative physiology: emphasis on the composition of body fluid compartments. Can J Physiol Pharmacol. 2002;80:835–50.

    Article  CAS  PubMed  Google Scholar 

  143. Davids MR, Lin SH, Edoute Y, Cheema-Dhadli S, Halperin ML. Hyponatraemia and hyperglycaemia during laproscopic surgery. QJM. 2002;95:321–30.

    Article  CAS  PubMed  Google Scholar 

  144. Davids MR, Edoute Y, Mallie JP, Bichet DG, Halperin ML. Body compartment volumes and composition after giving a vasopressin antagonist: changes are revealed by a tonicity balance. Nephrol Dial Transplant. 2002;17:300–3.

    Article  PubMed  Google Scholar 

  145. Davids MR, Chikte UME, Halperin ML. Development and evaluation of a multimedia e-learning resource for electrolyte and acid-base disorders. Adv Physiol Educ. 2011;35:295–306.

    Article  PubMed  Google Scholar 

  146. Davids MR, Chikte U, Halperin M. The electrolyte workshop: a multimedia case-based resource for learning about hyponatraemia. Washington, DC: MedEdPORTAL Publications; 2015.

    Google Scholar 

  147. Sethi SK, Raina R, McCulloch M, Bunchman TE. Critical care pediatric nephrology and dialysis: a practical handbook. Singapore: Springer; 2019.

    Book  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa

    Mogamat Razeen Davids & Mogamat-Yazied Chothia

  2. Division of Nephrology and Hypertension, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

    Nicola Wearne & Bianca Davidson

  3. Division of Paediatric Nephrology, University of Cape Town and Red Cross War Memorial Children’s Hospital, Cape Town, South Africa

    Mignon McCulloch

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  1. Mogamat Razeen Davids
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  2. Mogamat-Yazied Chothia
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  3. Nicola Wearne
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  4. Bianca Davidson
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  5. Mignon McCulloch
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Correspondence to Mogamat Razeen Davids .

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  1. Brazilian Society of Nephrology, Salvador, Bahia, Brazil

    José A. Moura-Neto

  2. Division of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Stockholms Län, Sweden

    José Carolino Divino-Filho

  3. DIMED - University of Padova, Department Nephrology Dialysis & Transplantation, International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, Italy

    Claudio Ronco

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Davids, M.R., Chothia, MY., Wearne, N., Davidson, B., McCulloch, M. (2021). Nephrology in South Africa. In: Moura-Neto, J.A., Divino-Filho, J.C., Ronco, C. (eds) Nephrology Worldwide. Springer, Cham. https://doi.org/10.1007/978-3-030-56890-0_6

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