Skip to main content

Autoantibodies in Neuro-Behçet Disease

  • Chapter
  • First Online:
Neuro-Behçet’s Disease
  • 234 Accesses

Abstract

Neurological complications of Behçet disease are difficult to diagnose and treat. Novel diagnostic tools are necessary for proper diagnosis and novel treatment options. In this chapter, we have evaluated findings regarding autoantibodies against neuronal structures in sera of Behçet disease patients. There are several direct antibodies like annexin V, anti-neuronal antibodies, as well as indirect path from Streptococcus sanguinis to neurofilament via cross autoimmunity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Greco A, De Virgilio A, Ralli M, et al. Behçet disease: new insights into pathophysiology, clinical features and treatment options. Autoimmun Rev. 2018;17:567–75.

    Article  CAS  PubMed  Google Scholar 

  2. Onder M, Bulur I. Behçet disease: new aspects. Clin Dermatol. 2017;35:421–34.

    Article  PubMed  Google Scholar 

  3. De Chambrun MP, Weschler B, Geri G, et al. New insights into the pathogenesis of Behçet’s disease. Autoimmun Rev. 2012;11:687–98.

    Article  Google Scholar 

  4. Yazici H, Seyahi E, Hatemi G, Yazici Y. Behçet syndrome: a contemporary view. Nat Rev Rheumatol. 2018;108(14):107–19.

    Article  Google Scholar 

  5. Casanova Peno I, De las Heras Revilla V, Parejo Carbonell B, et al. Neurobehçet disease: clinical and demographic characteristics. Eur J Neurol. 2012;19:1224–7.

    Article  PubMed  Google Scholar 

  6. Kalra S, Silman A, Akman-Demir G, et al. Diagnosis and management of Neuro-Behçet’s disease: international consensus recommendations. J Neurol. 2014;261:1662–76.

    Article  PubMed  Google Scholar 

  7. Miller JJ, Venna N, Siva A. Neuro-Behçet disease and autoinflammatory disorders. Semin Neurol. 2014;34:437–43.

    Article  PubMed  Google Scholar 

  8. Takeuchi M, Mizuki N, Meguro A, et al. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility. Nat Genet. 2017;49(3):438–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gül A. Pathogenesis of Behçet’s disease: autoinflammatory features and beyond. Semin Immunopathol. 2015;37:413–8.

    Article  PubMed  Google Scholar 

  10. Lule S, Colpak AI, Balci-Peynircioglu B, et al. Behçet disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger. J Autoimmun. 2017;84:87–96. https://doi.org/10.1016/j.jaut.2017.08.002.

    Article  CAS  PubMed  Google Scholar 

  11. Christmann Souza R, Lage L, Goldesntein-Schainberg C, et al. Anti-endothelial cell antibodies and central nervous system involvement in Behçet’s disease. Clinics. 2007;62(6):685–90. São Paulo. https://doi.org/10.1590/S1807-59322007000600005.

    Article  Google Scholar 

  12. Hoon Lee K, Chung H-S, Sup Kim H, et al. Human α-enolase from endothelial cells as a target antigen of anti–endothelial cell antibody in Behçet’s disease. Arthritis Rheum. 2003;48(7):2025–35.

    Article  Google Scholar 

  13. Fontan PA, Pancholi V, Nociari MM, Fischetti VA. Antibodies to streptococcal surface enolase react with human␣-enolase: implications in poststreptococcal sequelae. J Infect Dis. 2000;182:1712–21.

    Article  CAS  PubMed  Google Scholar 

  14. Akoglu T, Kozakoglu H, Akoglu E. Antibody to intermediate filaments of the cytoskeleton in patients with Behcet’s disease. Clin Immunol Immunopathol. 1986;41(3):427–43.

    Article  CAS  PubMed  Google Scholar 

  15. Lu Y, Ye P, Chen SL, et al. Identification of kinectin as a novel Behcet’s disease autoantigen. Arthritis Res Ther. 2005;7:R1133–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Mor F, Weinberger A, Cohen IR. Identification of alpha-tropomyosin as a target self-antigen in Behcet’s syndrome. Eur J Immunol. 2002;32:356–65.

    Article  CAS  PubMed  Google Scholar 

  17. Vural B, Demirkan A, Ugurel E, et al. Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behcet’s disease. Clin Exp Rheumatol. 2009;27:S67–72.

    CAS  PubMed  Google Scholar 

  18. Briani C, Doria A, Marcolongo R, et al. Increased titres of IgM anti-heparan sulfate antibody in Behcet’s disease. Clin Exp Rheumatol. 2006;24:S104–7.

    CAS  PubMed  Google Scholar 

  19. Delunardo F, Conti F, Margutti P, et al. Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behcet’s disease. Arthritis Res Ther. 2006;8:R71.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Aslan H, Pay S, Gok F, et al. Anti Annexin V autoantibody in thrombophilic Behcet’s disease. Rheumatol Int. 2004;24:77–9.

    Article  CAS  PubMed  Google Scholar 

  21. Chen P, Yan H, Tian Y, Xun Y, Shi L, Bao R, et al. Annexin A2 as a target endothelial cell membrane autoantigen in Behcet’s disease. Sci Rep. 2015;5:8162.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Vural B, Şehitoğlu E, ÇavuŞ F, et al. Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-BehÇet’s disease. J Neuroimmunol. 2013;263:139–44.

    Article  CAS  PubMed  Google Scholar 

  23. Gheita TA, Samir H, Hussein H. Anti-annexin V antibodies in neuro-Behçṃet patients: clinical significance and relation to disease activity. Int J Rheum Dis. 2012;15:e124–6.

    Article  PubMed  Google Scholar 

  24. Vural B, Uğurel E, Tüzün E. Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet’s disease. J Neuroimmunol. 2011;239:91–7.

    Article  CAS  PubMed  Google Scholar 

  25. Goëb V, Thomas-L’Otellier M, Daveau ea. Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes. Arthritis Res Ther. 2009;11:R38.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Kim S, Cho H, Nam EJ, Kim SW, Kim YT, Park YW, Kim BW, Kim JH. Autoantibodies against stress-induced phosphoprotein-1 as a novel biomarker candidate for ovarian cancer. Genes Chromosomes Cancer. 2010;49:585–95.

    CAS  PubMed  Google Scholar 

  27. Lehner T, Lavery E, Smith R, van der Zee R, Mizushima Y, Shinnick T. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet’s syndrome. Infect Immun. 1991;59:1434–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Nomura Y, Kitteringham N, Shiba K, Goseki M, Kimura A, Mineshita S. Use of the highly sensitive PCR method to detect the Herpes simplex virus type 1 genome and its expression in samples from Behcet disease patients. J Med Dent Sci. 1998;45:51–8.

    CAS  PubMed  Google Scholar 

  29. Marta M, Santos E, Coutinho E, et al. The role of infections in Behçet disease and neuro-Behçet syndrome. Autoimmun Rev. 2015;14:609–15.

    Article  CAS  PubMed  Google Scholar 

  30. Hatemi G, Yazıcı H. Behçet’s syndrome and micro-organisms. Best Pract Res Clin Rheumatol. 2011;25:389–406.

    Article  PubMed  Google Scholar 

  31. Yoshikawa K, Kotake S, Sasamoto Y, Ohno S, Matsuda H. Close association of Streptococcus sanguis and Behçet’s disease. Nippon Ganka Gakkai Zasshi. 1991;95(12):1261–7.

    CAS  PubMed  Google Scholar 

  32. Isogai E, Isogai H, Kotake S, Ohno S, Kimura K, Oguma K. Role of streptococcus sanguis and traumatic factors in Behçet’s disease. J Appl Res. 2003;3:64–75.

    CAS  Google Scholar 

  33. Behçet H. Über rezidivierende Aphtösedurch Ein Virus verursachte Geschwüre am Mund, am Auge und an der Genitalien. Derm Wschr. 1937;105(36):1152–63.

    Google Scholar 

  34. Sezer F. The isolation of a virus as the cause of Behçet’s disease. Am J Ophthalmol. 1953;36:301–6.

    Article  CAS  PubMed  Google Scholar 

  35. Eglin RP, Lehner T, Subak-Sharpe JH. Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behcet’s syndrome and recurrent oral ulcers. Lancet. 1982;2(8312):1356–61.

    Article  CAS  PubMed  Google Scholar 

  36. Studd M, McCance DJ, Lehner T. Detection of HSV-1 DNA in patients with Behcet’s syndrome and in patients with recurrent oral ulcers by the polymerase chain reaction. J Med Microbiol. 1991;34(1):39–43.

    Article  CAS  PubMed  Google Scholar 

  37. Lee S, Bang D, Cho YH, Lee ES, Sohn S. Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Behcet’s disease. Arch Dermatol Res. 1996;288:179–83.

    Article  CAS  PubMed  Google Scholar 

  38. Sohn S, Bang D, Lee ES, Kwon HJ, Lee SI, Lee S. Experimental studies on the antiviral agent famciclovir in Behçet’s disease symptoms in ICR mice. Br J Dermatol. 2001;145:799–804.

    Article  CAS  PubMed  Google Scholar 

  39. Davies UM, Palmer RG, Denman AM. Treatment with acyclovir does not affect orogenital ulcers in Behcet’s syndrome: a randomized double-blind trial. Br J Rheumatol. 1988;27(4):300–2.

    Article  CAS  PubMed  Google Scholar 

  40. Lehner T, Lavery E, Smith R, van der Zee R, Mizushima Y, Shinnick T. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet’s syndrome. Infect Immunol. 1991;59(4):1434–41.

    Article  CAS  Google Scholar 

  41. Direskeneli H, Hasan A, Shinnick T, Mizushima R, van der Zee R, Fortune F, et al. Recognition of B-cell epitopes of the 65 kDa HSP in Behcet’s disease. Scand J Immunol. 1996;43(4):464–71.

    Article  CAS  PubMed  Google Scholar 

  42. Kaneko F, Oyama N, Yanagihori H, Isogai E, Yokota K, Oguma K. The role of streptococcal hypersensitivity in the pathogenesis of Behcet’s disease. Eur J Dermatol. 2008;18:489–98.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yasemin Gürsoy-Özdemir .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gürsoy-Özdemir, Y. (2021). Autoantibodies in Neuro-Behçet Disease. In: Tüzün, E., Kürtüncü, M. (eds) Neuro-Behçet’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55273-2_3

Download citation

Publish with us

Policies and ethics