Skip to main content

Post-op Pancreatic Hemorrhage

  • Chapter
  • First Online:
Textbook of Pancreatic Cancer

Abstract

Postoperative pancreatic hemorrhage is a rare but severe complication, which accounts for nearly one-half of perioperative mortality and requires prompt recognition and adequate management. The International Study Group of Pancreatic Surgery (ISGPS) graded postpancreatectomy hemorrhage (PPH) in 2007 based on onset, location, and severity. Early hemorrhage is a result of insufficient hemostasis and is mostly treated by re-operation. An important warning sign for delayed hemorrhage is the “sentinel bleeding”, often associated with sepsis. The main cause of delayed hemorrhage is pseudoaneurysm. Patients should be first submitted to endovascular therapy and bleeding may be handled by applying coils or stent-grafting and complementarily by interventional drainage or surgery for the collection of infected fluid and for local sepsis control. Surgery may be challenging as a first choice therapy for late hemorrhage being a risk for new complications.

In general, outcome for postpancreatectomy bleeding seems to be better in high-volume hospitals and depends on early recognition and an adequately guided management.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Parikh P, Shiloach M, Cohen ME, Bilimoria KY, Ko CY, Hall BL, Pitt HA. Pancreatectomy risk calculator: an ACS-NSQIP resource. HPB. 2010;12:488–97. https://doi.org/10.1111/j.1477-2574.2010.00216.x.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Distler M, Rückert F, Hunger M, Kersting S, Pilarsky C, Saeger HD, Grützmann R. Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma. BMC Surg. 2013;13:12. https://doi.org/10.1186/1471-2482-13-12.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg. 2006;244:10–5. https://doi.org/10.1097/01.sla.0000217673.04165.ea.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Krautz C, Nimptsch U, Weber GF, Mansky T, Grützmann R. Effect of hospital volume on in-hospital morbidity and mortality following pancreatic surgery in Germany. Ann Surg. 2018;267:411–7.

    Article  Google Scholar 

  5. Choi SH, Moon HJ, Heo JS, Joh JW, Kim Y II. Delayed hemorrhage after pancreaticoduodenectomy. J Am Coll Surg. 2004;199:186–91.

    Article  Google Scholar 

  6. Yekebas EF, Wolfram L, Cataldegirmen G, et al. Postpancreatectomy hemorrhage: diagnosis and treatment—an analysis in 1669 consecutive pancreatic resections. Ann Surg. 2007;246:269–80.

    Article  Google Scholar 

  7. Tien YW, Wu YM, Liu KL, Ho CM, Lee PH. Angiography is indicated for every sentinel bleed after pancreaticoduodenectomy. Ann Surg Oncol. 2008;15:1855–61.

    Article  Google Scholar 

  8. Grützmann R, Rückert F, Hippe-Davies N, Distler M, Saeger HD. Evaluation of the international study Group of Pancreatic Surgery definition of post-pancreatectomy hemorrhage in a high-volume center. Surgery. 2012;151:612–20.

    Article  Google Scholar 

  9. Kasumova GG, Eskander MF, Kent TS, Ng SC, Moser AJ, Ahmed M, Pleskow DK, Callery MP, Tseng JF. Hemorrhage after pancreaticoduodenectomy: does timing matter? HPB. 2016;18:861–9.

    Article  Google Scholar 

  10. Floortje van Oosten A, Smits FJ, van den Heuvel DAF, van Santvoort HC, Molenaar IQ. Diagnosis and management of postpancreatectomy hemorrhage: a systematic review and meta-analysis. HPB. 2019;21:953–61.

    Article  CAS  Google Scholar 

  11. Brodsky JT, Turnbull ADM. Arterial hemorrhage after pancreatoduodenectomy: the ‘Sentinel Bleed.’. Arch Surg. 1991;126:1037–40. https://doi.org/10.1001/archsurg.1991.01410320127019.

    Article  CAS  PubMed  Google Scholar 

  12. Biondetti P, Fumarola EM, Ierardi AM, Carrafiello G. Bleeding complications after pancreatic surgery: interventional radiology management. Gland Surg. 2019;8:150–63.

    Article  Google Scholar 

  13. Miura F, Asano T, Amano H, et al. Management of postoperative arterial hemorrhage after pancreato-biliary surgery according to the site of bleeding: re-laparotomy or interventional radiology. J Hepatobiliary Pancreat Surg. 2009;16:56–63.

    Article  Google Scholar 

  14. Limongelli P, Khorsandi SE, Pai M, Jackson JE, Tait P, Tierris J, Habib NA, Williamson RCN, Jiao LR. Management of delayed postoperative hemorrhage after pancreaticoduodenectomy: a meta-analysis. Arch Surg. 2008;143:1001–7.

    Article  Google Scholar 

  15. Wolk S, Grützmann R, Rahbari NN, Hoffmann RT, Plodeck V, Weitz J, Welsch T, Distler M. Management of clinically relevant postpancreatectomy hemorrhage (PPH) over two decades—a comparative study of 1 50 consecutive patients undergoing pancreatic resection. Pancreatology. 2017;17:943–50.

    Article  Google Scholar 

  16. Reber PU, Baer HU, Patel AG, Wildi S, Triller J, Büchler MW. Superselective microcoil embolization: treatment of choice in high-risk patients with extrahepatic pseudoaneurysms of the hepatic arteries. J Am Coll Surg. 1998;186:325–30.

    Article  CAS  Google Scholar 

  17. Wente MN, Veit JA, Bassi C, et al. Postpancreatectomy hemorrhage (PPH)–an international study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142:20–5.

    Article  Google Scholar 

  18. Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the international study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142:761–8.

    Article  Google Scholar 

  19. Bassi C, Marchegiani G, Dervenis C, Sarr M. Pancreas the 2016 update of the international study group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery. 2016;161:584–91.

    Article  Google Scholar 

  20. Welsch T, Eisele H, Zschäbitz S, Hinz U, Büchler MW, Wente MN. Critical appraisal of the international study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomy. Langenbecks Arch Surg. 2011;396:783–91.

    Article  Google Scholar 

  21. Garcea G, Jackson B, Pattenden CJ, et al. Early warning scores predict outcome in acute pancreatitis. J Gastrointest Surg. 2006;10:1008–15.

    Article  Google Scholar 

  22. Rajarathinam G, Kannan DG, Vimalraj V, Amudhan A, Rajendran S, Jyotibasu D, Balachandar TG, Jeswanth S, Ravichandran P, Surendran R. Post pancreaticoduodenectomy haemorrhage: outcome prediction based on new ISGPS clinical severity grading. HPB. 2008;10:363–70.

    Article  CAS  Google Scholar 

  23. Correa-Gallego C, Brennan MF, D’Angelica MI, Dematteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ. Contemporary experience with postpancreatectomy hemorrhage: results of 1,122 patients resected between 2006 and 2011. J Am Coll Surg. 2012;215:616–21.

    Article  Google Scholar 

  24. Puppala S, Patel J, McPherson S, Nicholson A, Kessel D. Hemorrhagic complications after whipple surgery: imaging and radiologic intervention. Am J Roentgenol. 2011;196:192–7.

    Article  Google Scholar 

  25. Schäfer M, Heinrich S, Pfammatter T, Clavien PA. Management of delayed major visceral arterial bleeding after pancreatic surgery. HPB. 2011;13:132–8.

    Article  Google Scholar 

  26. Gaudon C, Soussan J, Louis G, Moutardier V, Gregoire E, Vidal V. Late postpancreatectomy hemorrhage: predictive factors of morbidity and mortality after percutaneous endovascular treatment. Diagn Interv Imaging. 2016;97:1071–7.

    Article  CAS  Google Scholar 

  27. Rumstadt B, Schwab M, Korth P, Samman M, Trede M. Hemorrhage after pancreatoduodenectomy. Ann Surg. 1998;227:236–41.

    Article  CAS  Google Scholar 

  28. Frattaroli FM, Casciani E, Spoletini D, Polettini E, Nunziale A, Bertini L, Vestri A, Gualdi G, Pappalardo G. Prospective study comparing multi-detector row ct and endoscopy in acute gastrointestinal bleeding. World J Surg. 2009;33:2209–17.

    Article  Google Scholar 

  29. Eckardt AJ, Klein F, Adler A, Veltzke-Schlieker W, Warnick P, Bahra M, Wiedenmann B, Neuhaus P, Neumann K, Glanemann M. Management and outcomes of haemorrhage after pancreatogastrostomy versus pancreatojejunostomy. Br J Surg. 2011;98:1599–607.

    Article  CAS  Google Scholar 

  30. Duarte Garcés AA, Andrianello S, Marchegiani G, Piccolo R, Secchettin E, Paiella S, Malleo G, Salvia R, Bassi C. Reappraisal of post-pancreatectomy hemorrhage (PPH) classifications: do we need to redefine grades a and B? HPB. 2018;20:702–7.

    Article  Google Scholar 

  31. Wellner UF, Kulemann B, Lapshyn H, Hoeppner J, Sick O, Makowiec F, Bausch D, Hopt UT, Keck T. Postpancreatectomy hemorrhage-incidence, treatment, and risk factors in over 1,000 pancreatic resections. J Gastrointest Surg. 2014;18:464–75.

    Article  CAS  Google Scholar 

  32. Chen Y-I, Yang JF, Friedland S, et al. Lumen apposing stents are superior to plastic stents in the management of pancreatic walled-off necrosis: a large international multicenter study. Gastrointest Endosc. 2017;85:AB470.

    Article  Google Scholar 

  33. Jilesen APJ, Tol JAMG, Busch ORC, Van Delden OM, Van Gulik TM, Van Dijkum EJMN, Gouma DJ. Emergency management in patients with late hemorrhage after pancreatoduodenectomy for a periampullary tumor. World J Surg. 2014;38:2438–47.

    Article  Google Scholar 

  34. Otah E, Cushin BJ, Rozenblit GN, Neff R, Otah KE, Cooperman AM. Visceral artery pseudoaneurysms following pancreatoduodenectomy. Arch Surg. 2002;137:55–9.

    Article  Google Scholar 

  35. Asai K, Zaydfudim V, Truty M, Reid-Lombardo K, Kendrick M, Que F, Nagorney D, Andrews J, Farnell M. Management of a delayed post-pancreatoduodenectomy haemorrhage using endovascular techniques. HPB. 2015;17:902–8.

    Article  Google Scholar 

  36. Blanc T, Cortes A, Goere D, Sibert A, Pessaux P, Belghiti J, Sauvanet A. Hemorrhage after pancreaticoduodenectomy: when is surgery still indicated? Am J Surg. 2007;194:3–9.

    Article  Google Scholar 

  37. Hata T, Motoi F, Ishida M, Naitoh T, Katayose Y, Egawa S, Unno M. Effect of hospital volume on surgical outcomes after pancreaticoduodenectomy: a systematic review and meta-analysis. Ann Surg. 2016;263:664–72.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Distler .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Radulova-Mauersberger, O., Weitz, J., Distler, M. (2021). Post-op Pancreatic Hemorrhage. In: Søreide, K., Stättner, S. (eds) Textbook of Pancreatic Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-53786-9_67

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-53786-9_67

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53785-2

  • Online ISBN: 978-3-030-53786-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics