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Epidemiology of Bone and Soft Tissue Sarcomas

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Sarcomas of Bone and Soft Tissues in Children and Adolescents

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Bone and soft tissue sarcomas collectively make up 12% of all pediatric malignancies. While there have been significant improvements in treatment for these sarcomas, mortality and morbidity are still high. There is also a substantial heterogeneity in the etiologies and biology of bone and soft tissue sarcomas, making these malignancies difficult to study from an epidemiologic perspective. Our understanding of risk factors for the development of these sarcomas remains limited to a few environmental exposures and well-described hereditary cancer predisposition syndromes. However, these factors are not consistent across all bone and soft tissue sarcomas. In this chapter, we review the epidemiology of bone and soft tissue sarcomas, including a discussion of the roles of environmental risk factors, established predisposing syndromes, and other suspected risk factors.

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Acknowledgments

This chapter is dedicated to our dear friend and colleague, Schuyler O’Brien (1991-2019). Schuyler was a committed scientist who worked tirelessly with the conviction that all data had the potential to become an important stepping-stone in cancer research. He was not content to make just a small contribution to the field of cancer research. Rather, he was singularly intent on dedicating all of himself to finding a cure, specifically a cure for Ewing sarcoma, a cancer he began battling at 12 years old that relapsed multiple times during his short lifetime. Facing so many relapses gave Schuyler a unique perspective, and he enjoyed gently and insightfully challenging his peers to work harder and better to understand the origins of childhood cancer. Somehow, despite years of physical suffering and intellectual exertion, Schuyler maintained a bewildering optimism and steadfast confidence in the power of science and in his ability to push through any difficulty to achieve his goals. Even though Schuyler was often—silently and unflinchingly—in pain from his multiple cancer treatments, he masterfully conducted his work over the years with an obsessive and somehow joyful passion. Schuyler never hesitated to patiently listen or lend a helping hand to his colleagues and friends. We are honored to have shared in his good-natured scientific zeal and marvel at his ability to conduct his life, like most cancer patients do, with simultaneous cynicism and hope, agony and joy. We dedicate this chapter, which Schuyler helped to write, to this young scientist who continues to serve as inspiration to all who knew him.

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Authors and Affiliations

  1. Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA

    Philip J. Lupo

  2. Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

    Logan G. Spector

  3. Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, USA

    Schuyler O’Brien & Joshua D. Schiffman

  4. Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany

    Simone Hettmer

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  1. Philip J. Lupo
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  2. Logan G. Spector
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  3. Schuyler O’Brien
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  5. Simone Hettmer
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Correspondence to Philip J. Lupo .

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  1. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA

    Carola A. S. Arndt

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Lupo, P.J., Spector, L.G., O’Brien, S., Schiffman, J.D., Hettmer, S. (2021). Epidemiology of Bone and Soft Tissue Sarcomas. In: Arndt, C.A.S. (eds) Sarcomas of Bone and Soft Tissues in Children and Adolescents. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-51160-9_1

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