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Benign Lesions and Physiologic Changes in the Cervix

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Atlas of Diagnostic Pathology of the Cervix
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Abstract

The uterine cervix undergoes physiological changes throughout a woman’s lifetime and during pregnancy. It forms the passageway to the uterine cavity and the entry point for ascending infections. A variety of metaplastic, inflammatory, infectious and reactive conditions can affect the cervix. These changes may be entirely physiologic or part of normal variant anatomy, or reactive in nature. Knowledge of these changes will help pathologists avoid confusion with malignant entities.

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References

  1. Reich O, Regauer S. Papillary immature metaplasia and thin high-grade squamous intraepithelial lesion originate in early metaplastic epithelium of the cervix. Arch Pathol Lab Med. 2019;143:279.

    Article  PubMed  Google Scholar 

  2. Hong SA, Yoo SH, Choi J, Robboy SJ, Kim K-R. A review and update on papillary immature metaplasia of the uterine cervix: a distinct subset of low-grade squamous intraepithelial lesion, proposing a possible cell of origin. Arch Pathol Lab Med. 2018;142:973–81.

    Article  CAS  PubMed  Google Scholar 

  3. Walts AE, Bose S. P16/Ki-67 immunostaining is useful in stratification of atypical metaplastic epithelium of the cervix. Clin Med Pathol. 2008;1:35–42.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Duggan MA, Akbari M, Magliocco AM. Atypical immature cervical metaplasia: immunoprofiling and longitudinal outcome. Hum Pathol. 2006;37:1473–81.

    Article  CAS  PubMed  Google Scholar 

  5. Iaconis L, Hyjek E, Ellenson LH, Pirog EC. p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. Arch Pathol Lab Med. 2007;131:1343–9.

    PubMed  Google Scholar 

  6. Trivijitsilp P, Mosher R, Sheets EE, Sun D, Crum CP. Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma. Hum Pathol. 1998;29:641–8.

    Article  CAS  PubMed  Google Scholar 

  7. Weir MM, Bell DA, Young RH. Transitional cell metaplasia of the uterine cervix and vagina: an underrecognized lesion that may be confused with high-grade dysplasia. A report of 59 cases. Am J Surg Pathol. 1997;21:510–7.

    Article  CAS  PubMed  Google Scholar 

  8. Egan AJ, Russell P. Transitional (urothelial) cell metaplasia of the uterine cervix: morphological assessment of 31 cases. Int J Gynecol Pathol. 1997;16:89–98.

    Article  CAS  PubMed  Google Scholar 

  9. Murali R, Loughman NT, Pagliuso J, McKenzie PR, Watson GF, Earls P, et al. Cytological features of transitional cell metaplasia of the lower female genital tract. Pathology. 2010;42:113–8.

    Article  PubMed  Google Scholar 

  10. Harnden P, Kennedy W, Andrew AC, Southgate J. Immunophenotype of transitional metaplasia of the uterine cervix. Int J Gynecol Pathol. 1999;18:125–9.

    Article  CAS  PubMed  Google Scholar 

  11. Ismail SM. Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia. Histopathology. 1991;18:107–14.

    Article  CAS  PubMed  Google Scholar 

  12. Oliva E, Clement PB, Young RH. Tubal and tubo-endometrioid metaplasia of the uterine cervix: unemphasized features that may cause problems in differential diagnosis: a report of 25 cases. Am J Clin Pathol. 1995;103:618–23.

    Article  CAS  PubMed  Google Scholar 

  13. Cameron RI, Maxwell P, Jenkins D, McCluggage WG. Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia. Histopathology. 2002;41:313–21.

    Article  CAS  PubMed  Google Scholar 

  14. Baker PM, Clement PB, Bell DA, Young RH. Superficial endometriosis of the uterine cervix: a report of 20 cases of a process that may be confused with endocervical glandular dysplasia or adenocarcinoma in situ. Int J Gynecol Pathol. 1999;18:198–205.

    Article  CAS  PubMed  Google Scholar 

  15. Nicolae A, Goyenaga P, McCluggage WG, Preda O, Nogales FF. Endometrial intestinal metaplasia: a report of two cases, including one associated with cervical intestinal and pyloric metaplasia. Int J Gynecol Pathol. 2011;30:492–6.

    Article  PubMed  Google Scholar 

  16. Mikami Y. Gastric-type mucinous carcinoma of the cervix and its precursors – historical overview. Histopathology. 2020;76:102–11.

    Article  PubMed  Google Scholar 

  17. Jones MA, Young RH. Atypical oxyphilic metaplasia of the endocervical epithelium: a report of six cases. Int J Gynecol Pathol. 1997;16:99–102.

    Article  CAS  PubMed  Google Scholar 

  18. Trowell JE. Intestinal metaplasia with argentaffin cells in the uterine cervix. Histopathology. 1985;9:551–9.

    Article  CAS  PubMed  Google Scholar 

  19. Sivridis E, Karpathiou G, Malamou-Mitsi V, Giatromanolaki A. Intestinal-type metaplasia in the original squamous epithelium of the cervix. Eur J Gynaecol Oncol. 2010;31:319–22.

    CAS  PubMed  Google Scholar 

  20. Nucci MR, Ferry JA, Young RH. Ectopic prostatic tissue in the uterine cervix: a report of four cases and review of ectopic prostatic tissue. Am J Surg Pathol. 2000;24:1224–30.

    Article  CAS  PubMed  Google Scholar 

  21. Kelly P, McBride HA, Kennedy K, Connolly LE, McCluggage WG. Misplaced Skene’s glands: Glandular elements in the lower female genital tract that are variably immunoreactive with prostate markers and that encompass vaginal tubulosquamous polyp and cervical ectopic prostatic tissue. Int J Gynecol Pathol. 2011;30:605–12.

    Article  PubMed  Google Scholar 

  22. McCluggage WG, Ganesan R, Hirschowitz L, Miller K, Rollason TP. Ectopic prostatic tissue in the uterine cervix and vagina: report of a series with a detailed immunohistochemical analysis. Am J Surg Pathol. 2006;30:209–15.

    Article  PubMed  Google Scholar 

  23. Roma AA. Sebaceous glands in the uterine cervix and vaginal wall: congenital misplacement, metaplastic process, or both? Int J Gynecol Pathol. 2010;29:488–9.

    Article  PubMed  Google Scholar 

  24. Rosa M, Moore G. Epidermalization of cervix and vagina: an unsolved dilemma. J Low Genit Tract Dis. 2008;12:217–9.

    Article  PubMed  Google Scholar 

  25. Szumiło J, Patel A, Patel S, Burdan F. Sebaceous glands: unusual histological finding in the uterine cervix. Folia Morphol (Warsz). 2009;68:287–9.

    Google Scholar 

  26. Kazakov DV, Hejda V, Kacerovska D, Michal M. Hyperplasia of ectopic sebaceous glands in the uterine cervix: case report. Int J Gynecol Pathol. 2010;29:605–8.

    Article  PubMed  Google Scholar 

  27. Alsaqobi A, Al-Brahim N. Osseous metaplasia of the cervix: a rare transformation can mimic a tumor. Literature review. Case Rep Pathol. 2018;2018:1392975.

    PubMed  PubMed Central  Google Scholar 

  28. Giannella L, Gelli MC, Mfuta K, Prandi S. A postconization hematometra revealed a rare case of endocervical bone metaplasia. J Low Genit Tract Dis. 2014;18:E19–22.

    Article  PubMed  Google Scholar 

  29. Elkattan E, Abdelbadei M, Abdelmoaty H, Ali E, Samir D, Kheidr H. Osseous metaplasia of the cervix: a rare transformation. J Turk Ger Gynecol Assoc. 2015;16:58–9.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Bedaiwy MA, Goldberg JM, Biscotti CV. Recurrent osseous metaplasia of the cervix after loop electrosurgical excision. Obstet Gynecol. 2001;98:968–70.

    CAS  PubMed  Google Scholar 

  31. Sabatini L, Rainey AJ, Tenuwara W, Webb JB. Osseous metaplasia of cervical epithelium. BJOG. 2001;108:333–4.

    CAS  PubMed  Google Scholar 

  32. Siddon A, Hui P. Glial heterotopia of the uterine cervix: DNA genotyping confirmation of its fetal origin. Int J Gynecol Pathol. 2010;29:394–7.

    Article  PubMed  Google Scholar 

  33. Doldan A, Otis CN, Pantanowitz L. Adipose tissue: a normal constituent of the uterine cervical stroma. Int J Gynecol Pathol. 2009;28:396–400.

    Article  PubMed  Google Scholar 

  34. Nucci MR. Pseudoneoplastic glandular lesions of the uterine cervix: a selective review. Int J Gynecol Pathol. 2014;33:330–8.

    Article  PubMed  Google Scholar 

  35. Roh MH, Agoston E, Birch C, Crum CP. P16 immunostaining patterns in microglandular hyperplasia of the cervix and their significance. Int J Gynecol Pathol. 2009;28:107–13.

    Article  PubMed  Google Scholar 

  36. Previs RA, Edwards JM, Secord AA, Nucci MR, Bentley RC, Hall AHS. Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report. Int J Gynecol Pathol. 2014;33:100–4.

    Article  PubMed  Google Scholar 

  37. Young RH, Scully RE. Atypical forms of microglandular hyperplasia of the cervix simulating carcinoma. A report of five cases and review of the literature. Am J Surg Pathol. 1989;13:50–6.

    Article  CAS  PubMed  Google Scholar 

  38. Young RH, Clement PB. Pseudoneoplastic glandular lesions of the uterine cervix. Semin Diagn Pathol. 1991;8:234–49.

    CAS  PubMed  Google Scholar 

  39. Loureiro J, Oliva E. The spectrum of cervical glandular neoplasia and issues in differential diagnosis. Arch Pathol Lab Med. 2014;138:453–83.

    Article  PubMed  Google Scholar 

  40. Qiu W, Mittal K. Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium. Int J Gynecol Pathol. 2003;22:261–5.

    Article  PubMed  Google Scholar 

  41. Nucci MR, Clement PB, Young RH. Lobular endocervical glandular hyperplasia, not otherwise specified: a clinicopathologic analysis of thirteen cases of a distinctive pseudoneoplastic lesion and comparison with fourteen cases of adenoma malignum. Am J Surg Pathol. 1999;23:886–91.

    Article  CAS  PubMed  Google Scholar 

  42. Mikami Y, Hata S, Fujiwara K, Imajo Y, Kohno I, Manabe T. Florid endocervical glandular hyperplasia with intestinal and pyloric gland metaplasia: worrisome benign mimic of “adenoma malignum”. Gynecol Oncol. 1999;74:504–11.

    Article  CAS  PubMed  Google Scholar 

  43. Kato N, Sugawara M, Maeda K, Hosoya N, Motoyama T. Pyloric gland metaplasia/differentiation in multiple organ systems in a patient with Peutz-Jegher’s syndrome. Pathol Int. 2011;61:369–72.

    Article  PubMed  Google Scholar 

  44. Talia KL, McCluggage WG. The developing spectrum of gastric-type cervical glandular lesions. Pathology. 2018;50:122–33.

    Article  PubMed  Google Scholar 

  45. Matsubara A, Sekine S, Ogawa R, Yoshida M, Kasamatsu T, Tsuda H, et al. Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations. Am J Surg Pathol. 2014;38:370–6.

    Article  PubMed  Google Scholar 

  46. Jones MA, Young RH, Scully RE. Diffuse laminar endocervical glandular hyperplasia. A benign lesion often confused with adenoma malignum (minimal deviation adenocarcinoma). Am J Surg Pathol. 1991;15:1123–9.

    Article  CAS  PubMed  Google Scholar 

  47. Fluhmann CF. Focal hyperplasis (tunnel clusters) of the cervix uteri. Obstet Gynecol. 1961;17:206–14.

    CAS  PubMed  Google Scholar 

  48. Segal GH, Hart WR. Cystic endocervical tunnel clusters. A clinicopathologic study of 29 cases of so-called adenomatous hyperplasia. Am J Surg Pathol. 1990;14:895–903.

    Article  CAS  PubMed  Google Scholar 

  49. Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ. PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. Am J Surg Pathol. 2010;34:137–46.

    Article  PubMed  Google Scholar 

  50. Daya D, Young RH. Florid deep glands of the uterine cervix. Another mimic of adenoma malignum. Am J Clin Pathol. 1995;103:614–7.

    Article  CAS  PubMed  Google Scholar 

  51. Clement PB, Young RH. Deep nabothian cysts of the uterine cervix. A possible source of confusion with minimal-deviation adenocarcinoma (adenoma malignum). Int J Gynecol Pathol. 1989;8:340–8.

    Article  CAS  PubMed  Google Scholar 

  52. Young RH, Clement PB. Endocervicosis involving the uterine cervix: a report of four cases of a benign process that may be confused with deeply invasive endocervical adenocarcinoma. Int J Gynecol Pathol. 2000;19:322–8.

    Article  CAS  PubMed  Google Scholar 

  53. Mirkovic J, Schoolmeester JK, Campbell F, Miron A, Nucci MR, Howitt BE. Cervical mesonephric hyperplasia lacks KRAS/NRAS mutations. Histopathology. 2017;71:1003–5.

    Article  PubMed  Google Scholar 

  54. Jones MA, Andrews J, Tarraza HM. Mesonephric remnant hyperplasia of the cervix: a clinicopathologic analysis of 14 cases. Gynecol Oncol. 1993;49:41–7.

    Article  CAS  PubMed  Google Scholar 

  55. Howitt BE, Nucci MR. Mesonephric proliferations of the female genital tract. Pathology. 2018;50:141–50.

    Article  PubMed  Google Scholar 

  56. Seidman JD, Tavassoli FA. Mesonephric hyperplasia of the uterine cervix: a clinicopathologic study of 51 cases. Int J Gynecol Pathol. 1995;14:293–9.

    Article  CAS  PubMed  Google Scholar 

  57. Ferry JA, Scully RE. Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases. Am J Surg Pathol. 1990;14:1100–11.

    Article  CAS  PubMed  Google Scholar 

  58. Pors J, Cheng A, Leo JM, Kinloch MA, Gilks B, Hoang L. A comparison of GATA3, TTF1, CD10, and calretinin in identifying mesonephric and mesonephric-like carcinomas of the gynecologic tract. Am J Surg Pathol. 2018;42:1596–606.

    Article  PubMed  Google Scholar 

  59. Roma AA, Goyal A, Yang B. Differential expression patterns of GATA3 in uterine mesonephric and nonmesonephric lesions. Int J Gynecol Pathol. 2015;34:480–6.

    Article  CAS  PubMed  Google Scholar 

  60. Howitt BE, Emori MM, Drapkin R, Gaspar C, Barletta JA, Nucci MR, et al. GATA3 is a sensitive and specific marker of benign and malignant mesonephric lesions in the lower female genital tract. Am J Surg Pathol. 2015;39:1411–9.

    Article  PubMed  Google Scholar 

  61. Kenny SL, McBride HA, Jamison J, McCluggage WG. Mesonephric adenocarcinomas of the uterine cervix and corpus: HPV-negative neoplasms that are commonly PAX8, CA125, and HMGA2 positive and that may be immunoreactive with TTF1 and hepatocyte nuclear factor 1-β. Am J Surg Pathol. 2012;36:799–807.

    Article  PubMed  Google Scholar 

  62. Casey S, McCluggage WG. Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected]. Histopathology. 2015;66:420–9.

    Article  PubMed  Google Scholar 

  63. Clement PB, Young RH, Keh P, Ostör AG, Scully RE. Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component. Am J Surg Pathol. 1995;19:1158–71.

    Article  CAS  PubMed  Google Scholar 

  64. Tambouret R, Clement PB, Young RH. Endometrial endometrioid adenocarcinoma with a deceptive pattern of spread to the uterine cervix: a manifestation of stage IIb endometrial carcinoma liable to be misinterpreted as an independent carcinoma or a benign lesion. Am J Surg Pathol. 2003;27:1080–8.

    Article  PubMed  Google Scholar 

  65. Jayakumar NK. Cervicitis: How often is it non-specific! J Clin Diagn Res. 2015;9(3):EC11–2.

    PubMed  PubMed Central  Google Scholar 

  66. Young RH, Harris NL, Scully RE. Lymphoma-like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol. 1985;4:289–99.

    Article  CAS  PubMed  Google Scholar 

  67. Singh A, Vats G, Radhika AG, Meena P, Radhakrisnan G. Cervical xanthogranuloma in a case of postmenopausal pyometra. Obstet Gynecol Sci. 2016;59:411–4.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Ramdial PK, Sing Y, Chotey NA, Bagratee JS. Concomitant malacoplakia and granuloma inguinale of the cervix in acquired immune deficiency syndrome. Int J Gynecol Pathol. 2008;27:282–7.

    PubMed  Google Scholar 

  69. Stewart CJ, Thomas MA. Malacoplakia of the uterine cervix and endometrium. Cytopathology. 1991;2:271–5.

    Article  CAS  PubMed  Google Scholar 

  70. Baithun M, Freeman-Wang T, Chowdary P, Kadir RA. Ligneous cervicitis and endometritis: a gynaecological presentation of congenital plasminogen deficiency. Haemophilia. 2018;24:359–65.

    Article  CAS  PubMed  Google Scholar 

  71. Taube ET, Frangini S, Caselitz J, Chiantera V, Pahl S, Vercellino GF, et al. Ligneous cervicitis in a woman with plasminogen deficiency associated with an atypical form of microglandular hyperplasia: a case report and review of literature. Int J Gynecol Pathol. 2013;32:329–34.

    Article  PubMed  Google Scholar 

  72. Ganesan R, Ferryman SR, Meier L, Rollason TP. Vasculitis of the female genital tract with clinicopathologic correlation: a study of 46 cases with follow-up. Int J Gynecol Pathol. 2000;19:258–65.

    Article  CAS  PubMed  Google Scholar 

  73. Roma AA, Amador-Ortiz C, Liapis H. Significance of isolated vasculitis in the gynecological tract: what clinicians do with the pathologic diagnosis of vasculitis? Ann Diagn Pathol. 2014;18:199–202.

    Article  PubMed  Google Scholar 

  74. Hernández-Rodríguez J, Tan CD, Rodríguez ER, Hoffman GS. Gynecologic vasculitis: an analysis of 163 patients. Medicine (Baltimore). 2009;88:169–81.

    Article  Google Scholar 

  75. Cheung VYT, Ma PWS. Cervical ulcer in Behçet’s disease. J Obstet Gynaecol Can. 2011;33:201.

    Article  PubMed  Google Scholar 

  76. Paavonen J, Vesterinen E, Meyer B, Saksela E. Colposcopic and histologic findings in cervical chlamydial infection. Obstet Gynecol. 1982;59:712–5.

    CAS  PubMed  Google Scholar 

  77. Agarwal J, Gupta JK. Female genital tuberculosis – a retrospective clinico-pathologic study of 501 cases. Indian J Pathol Microbiol. 1993;36:389–97.

    CAS  PubMed  Google Scholar 

  78. McGalie CE, McBride HA, McCluggage WG. Cytomegalovirus infection of the cervix: morphological observations in five cases of a possibly under-recognised condition. J Clin Pathol. 2004;57:691–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Andrianjafitrimo HT, Ranaivomanana VF, Ravelomampitoniainarivony TM, Ramiandrasoa LA, Randrianjafisamindrakotroka NS. Schistosomiasis of the female genital tract: a two-center study. Med Sante Trop. 2019;29:306–9.

    CAS  PubMed  Google Scholar 

  80. Helling-Giese G, Sjaastad A, Poggensee G, Kjetland EF, Richter J, Chitsulo L, et al. Female genital schistosomiasis (FGS): relationship between gynecological and histopathological findings. Acta Trop. 1996;62:257–67.

    Article  CAS  PubMed  Google Scholar 

  81. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol. 1981;25:224–8.

    CAS  PubMed  Google Scholar 

  82. Nucci MR, Young RH. Arias-Stella reaction of the endocervix: a report of 18 cases with emphasis on its varied histology and differential diagnosis. Am J Surg Pathol. 2004;28:608–12.

    Article  PubMed  Google Scholar 

  83. Arias-Stella J. The Arias-Stella reaction: facts and fancies four decades after. Adv Anat Pathol. 2002;9:12–23.

    Article  PubMed  Google Scholar 

  84. Ip PPC, Wang S-Y, Wong OGW, Chow K-L, Lee HH-Y, Cheung ANY, et al. Napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors expression in Arias-Stella reaction. Am J Surg Pathol. 2019;43:325–33.

    Article  PubMed  Google Scholar 

  85. Vang R, Barner R, Wheeler DT, Strauss BL. Immunohistochemical staining for Ki-67 and p53 helps distinguish endometrial Arias-Stella reaction from high-grade carcinoma, including clear cell carcinoma. Int J Gynecol Pathol. 2004;23:223–33.

    Article  PubMed  Google Scholar 

  86. Ji JX, Cochrane DR, Tessier-Cloutier B, Leung S, Cheng AS, Chow C, et al. Use of immunohistochemical markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to distinguish endometrial clear cell carcinoma from its morphologic mimics including Arias-Stella reaction. Int J Gynecol Pathol. 2019. https://doi.org/10.1097/PGP.0000000000000609int.

  87. Yelverton CL, Bentley RC, Olenick S, Krigman HR, Johnston WW, Robboy SJ. Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. Int J Gynecol Pathol. 1996;15:338–44.

    Article  CAS  PubMed  Google Scholar 

  88. Val-Bernal JF, Pinto J, Garijo MF, Gómez MS. Pagetoid dyskeratosis of the cervix: an incidental histologic finding in uterine prolapse. Am J Surg Pathol. 2000;24:1518–23.

    Article  CAS  PubMed  Google Scholar 

  89. Boyle DP, McCluggage WG. Pseudoinvasion of benign squamous epithelium following cervical biopsy: a pseudoneoplastic phenomenon mimicking invasive squamous carcinoma. J Clin Pathol. 2011;64:1093–6.

    Article  PubMed  Google Scholar 

  90. Lesack D, Wahab I, Gilks CB. Radiation-induced atypia of endocervical epithelium: a histological, immunohistochemical and cytometric study. Int J Gynecol Pathol. 1996;15:242–7.

    Article  CAS  PubMed  Google Scholar 

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Hoang, L.N. (2021). Benign Lesions and Physiologic Changes in the Cervix. In: Soslow, R.A., Park, K.J., Stolnicu, S. (eds) Atlas of Diagnostic Pathology of the Cervix. Springer, Cham. https://doi.org/10.1007/978-3-030-49954-9_3

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