Abstract
Binge eating is a complex condition influenced by biological and environmental factors. The heritability of binge eating has been estimated at 38–57% in populations of European ancestry. Studies of epigenetic mechanisms such as deoxyribonucleic acid (DNA) methylation and gene expression revealed a potential gene by environment effect on binge eating. Sex hormones also play a significant role in binge eating such that the combined effects of estrogen and progesterone may contribute to the vulnerability for binge eating. Genetic influences on binge eating might increase during the pubertal period, suggesting an interaction between genetic factors and sex hormones on the risk for binge eating.
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References
Albertz J, Boersma GJ, Tamashiro KL et al (2018) The effects of scheduled running wheel access on binge-like eating behavior and its consequences. Appetite 126:176–184. https://doi.org/10.1016/j.appet.2018.04.011
Almey A, Milner TA, Brake WG (2015) Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Horm Behav 74:125–138. https://doi.org/10.1016/j.yhbeh.2015.06.010
Baker JH, Girdler SS, Bulik CM (2012) The role of reproductive hormones in the development and maintenance of eating disorders. Expert Rev Obstet Gynecol 7:573–583. https://doi.org/10.1586/eog.12.54
Balsevich G, Sticht M, Bowles NP et al (2018) Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proc Natl Acad Sci USA 115(29):7605–7610. https://doi.org/10.1073/pnas.1802251115
Bulik CM, Sullivan PF, Kendler KS (1998) Heritability of binge-eating and broadly defined bulimia nervosa. Biol Psychiatry 44(12):1210–1218
Butera PC (2010) Estradiol and the control of food intake. Physiol Behav 99(2):175–180. https://doi.org/10.1016/j.physbeh.2009.06.010
Capusan AJ, Yao S, Kuja-Halkola R et al (2017) Genetic and environmental aspects in the association between attention-deficit hyperactivity disorder symptoms and binge-eating behavior in adults: a twin study. Psychol Med 47(16):2866–2878. https://doi.org/10.1017/s0033291717001416
Culbert KM, Burt SA, Sisk CL et al (2014) The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males. Psychol Med 44(11):2271–2286. https://doi.org/10.1017/s0033291713003073
Culbert KM, Breedlove SM, Sisk CL et al (2015) Age differences in prenatal testosterone’s protective effects on disordered eating symptoms: developmental windows of expression? Behav Neurosci 129(1):18–36. https://doi.org/10.1037/bne0000034
Culbert KM, Burt SA, Klump KL (2017) Expanding the developmental boundaries of etiologic effects: the role of adrenarche in genetic influences on disordered eating in males. J Abnorm Psychol 126(5):593–606. https://doi.org/10.1037/abn0000226
Culbert KM, Sinclair EB, Hildebrandt BA et al (2018) Perinatal testosterone contributes to mid-to-post pubertal sex differences in risk for binge eating in male and female rats. J Abnorm Psychol 127(2):239–250. https://doi.org/10.1037/abn0000334
Edler C, Lipson SF, Keel PK (2007) Ovarian hormones and binge eating in bulimia nervosa. Psychol Med 37:131–141. https://doi.org/10.1017/s0033291706008956
Farr OM, Li CS, Mantzoros CS (2016) Central nervous system regulation of eating: insights from human brain imaging. Metabolism 65:699–713. https://doi.org/10.1016/j.metabol.2016.02.002
Gordon JL, Rubinow DR, Eisenlohr-Moul TA et al (2016) Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition. Menopause 23(3):257–266. https://doi.org/10.1097/gme.0000000000000528
Hudson JI, Lalonde JK, Berry JM et al (2006) Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry 63(3):313–319. https://doi.org/10.1001/archpsyc.63.3.313
Iwasa T, Matsuzaki T, Tungalagsuvd A et al (2016) Effects of chronic testosterone administration on body weight and food intake differ among pre-pubertal, gonadal-intact, and ovariectomized female rats. Behav Brain Res 309:35–43. https://doi.org/10.1016/j.bbr.2016.04.048
Javaras KN, Laird NM, Reichborn-Kjennerud T et al (2008) Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study. Int J Eat Disord 41(2):174–179. https://doi.org/10.1002/eat.20484
Jia YF, Choi Y, Ayers-Ringler JR et al (2017) Differential SLC1A2 promoter methylation in bipolar disorder with or without addiction. Front Cell Neurosci 11:217. https://doi.org/10.3389/fncel.2017.00217
Klump KL, Keel PK, Culbert KM et al (2008) Ovarian hormones and binge eating: exploring associations in community samples. Psychol Med 38(12):1749–1757. https://doi.org/10.1017/s0033291708002997
Klump KL, Keel PK, Sisk C et al (2010) Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol Med 40(10):1745–1753. https://doi.org/10.1017/s0033291709992236
Klump KL, Suisman JL, Culbert KM et al (2011) Binge eating proneness emerges during puberty in female rats: a longitudinal study. J Abnorm Psychol 120(4):948–955. https://doi.org/10.1037/a0023600
Klump KL, Keel PK, Racine SE et al (2013) The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. J Abnorm Psychol 122(1):131–137. https://doi.org/10.1037/a0029524
Klump KL, Racine SE, Hildebrandt B et al (2014) Ovarian hormone influences on dysregulated eating: a comparison of associations in women with versus without binge episodes. Clin Psychol Sci 2(4):545–559. https://doi.org/10.1177/2167702614521794
Klump KL, Culbert KM, O’Connor S et al (2017a) The significant effects of puberty on the genetic diathesis of binge eating in girls. Int J Eat Disord 50(8):984–989. https://doi.org/10.1002/eat.22727
Klump KL, Culbert KM, Sisk CL (2017b) Sex differences in binge eating: gonadal hormone effects across development. Annu Rev Clin Psychol 13:183–207. https://doi.org/10.1146/annurev-clinpsy-032816-045309
Klump KL, Fowler N, Mayhall L et al (2018) Estrogen moderates genetic influences on binge eating during puberty: disruption of normative processes? J Abnorm Psychol 127(5):458–470. https://doi.org/10.1037/abn0000352
Leeners B, Geary N, Tobler PN et al (2017) Ovarian hormones and obesity. Hum Reprod Update 23(3):300–321. https://doi.org/10.1093/humupd/dmw045
McElroy SL, Winham SJ, Cuellar-Barboza AB et al (2018) Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. Transl Psychiatry 8(1):40. https://doi.org/10.1038/s41398-017-0085-3
Micioni Di Bonaventura MV, Pucci M, Giusepponi ME et al (2019) Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. J Psychopharmacol 33:1550–1561. https://doi.org/10.1177/0269881119845798
Mikhail ME, Culbert KM, Sisk CL et al (2019) Gonadal hormone contributions to individual differences in eating disorder risk. Curr Opin Psychiatry 32(6):484–490. https://doi.org/10.1097/yco.0000000000000543
Mitchell KS, Neale MC, Bulik CM et al (2010) Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability. Psychol Med 40(11):1899–1906. https://doi.org/10.1017/s0033291710000139
Munn-Chernoff MA, Duncan AE, Grant JD et al (2013) A twin study of alcohol dependence, binge eating, and compensatory behaviors. J Stud Alcohol Drugs 74(5):664–673
Munn-Chernoff MA, Grant JD, Agrawal A et al (2015) Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American female twins? Int J Eat Disord 48(4):375–382. https://doi.org/10.1002/eat.22280
National Human Genome Research Institute (2015) Genome-wide association studies fact sheet. https://www.genome.gov/about-genomics/fact-sheets/Genome-Wide-Association-Studies-Fact-Sheet. Accessed 20 July 2007
Pucci M, Micioni Di Bonaventura MV, Zaplatic E et al (2018) Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. Int J Eat Disord 52(1):51–60. https://doi.org/10.1002/eat.22989
Reichborn-Kjennerud T, Bulik CM, Tambs K et al (2004) Genetic and environmental influences on binge eating in the absence of compensatory behaviors: a population-based twin study. Int J Eat Disord 36(3):307–314. https://doi.org/10.1002/eat.20047
Richardson TG, Harrison S, Hemani G et al (2019) An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome. Elife 8:e43657. https://doi.org/10.7554/eLife.43657
Roney JR, Simmons ZL (2017) Ovarian hormone fluctuations predict within-cycle shifts in women’s food intake. Horm Behav 90:8–14. https://doi.org/10.1016/j.yhbeh.2017.01.009
Root TL, Thornton LM, Lindroos AK et al (2010) Shared and unique genetic and environmental influences on binge eating and night eating: a Swedish twin study. Eat Behav 11(2):92–98. https://doi.org/10.1016/j.eatbeh.2009.10.004
Schroeder M, Jakovcevski M, Polacheck T et al (2018) Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease. Mol Metab 17:1–16. https://doi.org/10.1016/j.molmet.2018.08.005
Solmi F, Mascarell MC, Zammit S et al (2019) Polygenic risk for schizophrenia, disordered eating behaviours and body mass index in adolescents. Br J Psychiatry 215(1):1–6. https://doi.org/10.1192/bjp.2019.39
Sugrue LP, Desikan RS (2019) What are polygenic scores and why are they important? JAMA 321:1820–1821. https://doi.org/10.1001/jama.2019.3893
Thornton LM, Mazzeo SE, Bulik CM (2011) The heritability of eating disorders: methods and current findings. Curr Top Behav Neurosci 6:141–156. https://doi.org/10.1007/7854_2010_91
Torkamani A, Wineinger NE, Topol EJ (2018) The personal and clinical utility of polygenic risk scores. Nat Rev Genet 19(9):581–590. https://doi.org/10.1038/s41576-018-0018-x
Wade TD, Gordon S, Medland S et al (2013) Genetic variants associated with disordered eating. Int J Eat Disord 46:594–608. https://doi.org/10.1002/eat.22133
Winham SJ, Cuellar-Barboza AB, Mcelroy SL et al (2014) Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. J Affect Disord 165:151–158. https://doi.org/10.1016/j.jad.2014.04.026
Wray NR, Goddard ME, Visscher PM (2008) Prediction of individual genetic risk of complex disease. Curr Opin Genet Dev 18:257–263. https://doi.org/10.1016/j.gde.2008.07.006
Yu Z, Geary N, Corwin RL (2008) Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats. Physiol Behav 95(3):501–507. https://doi.org/10.1016/j.physbeh.2008.07.021
Yu Z, Geary N, Corwin RL (2011) Individual effects of estradiol and progesterone on food intake and body weight in ovariectomized binge rats. Physiol Behav 104(5):687–693. https://doi.org/10.1016/j.physbeh.2011.07.017
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Wu, YK., Breiner, C.E., Baker, J.H. (2020). Influence of Genetics and Sex Hormones on Binge Eating. In: Frank, G., Berner, L. (eds) Binge Eating. Springer, Cham. https://doi.org/10.1007/978-3-030-43562-2_11
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DOI: https://doi.org/10.1007/978-3-030-43562-2_11
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