Abstract
Stiff-person spectrum disorders (SPSD) are autoimmune disorders. Glutamic acid decarboxylase (GAD) is an intracellular presynaptic antigen which belongs to a unique category, different from onconeuronal antigens and postsynaptic proteins. However, the pathophysiology and the roles of anti-GAD65 antibodies remain unclear. Controversies regarding anti-GAD65 antibodies include whether the pathophysiology is mainly antibody- or T-cell-mediated and whether the antibodies have direct pathogenic role or just represent a biomarker. Current knowledge gaps also include interaction between anti-GAD65 antibodies and intracellular GAD65 antigen, as well as immunopathogenesis of other less common antibodies associated with SPSD.
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Termsarasab, P., Thammongkolchai, T., Katirji, B. (2020). Immunopathogenesis of Stiff-Person Spectrum Disorders. In: Stiff-Person Syndrome and Related Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-43059-7_6
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DOI: https://doi.org/10.1007/978-3-030-43059-7_6
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