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Mechanisms Underlying the Development of Cardiac Arrhythmias

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Management of Cardiac Arrhythmias

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Normal cardiac rhythm is fairly regular and typically ranges between 50 and 90 beats per minute in adults at rest and up to 220 beats per minute during physical activity and/or emotional stress. A cardiac arrhythmia simply defined is a variation from the normal heart rhythm that is not physiologically justified. Arrhythmia can be regular or irregular (such as tachycardia and fibrillation, respectively) as well as slower or faster than the normal resting rate (brady- and tachyarrhythmias, respectively). In this chapter, our principal focus is on mechanisms underlying the development of tachyarrhythmias. These are generally divided into two major categories: (1) enhanced or abnormal impulse formation (i.e., focal activity) and (2) abnormal conduction leading to reentry

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Supported by grants from the NIH (HL47678 and HL138103), W. W Smith Charitable Trust (H1802) and the Martha and Wistar Morris Fund.

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Authors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Alexander Burashnikov & Charles Antzelevitch

  2. Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA

    Alexander Burashnikov & Charles Antzelevitch

  3. Lankenau Heart Institute, Wynnewood, PA, USA

    Charles Antzelevitch

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  1. Alexander Burashnikov
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  2. Charles Antzelevitch
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Editors and Affiliations

  1. Lankenau Heart Institute, Thomas Jefferson University, Wynnewood, PA, USA

    Gan-Xin Yan

  2. Lankenau Heart Institute, Thomas Jefferson University, Wynnewood, PA, USA

    Peter R. Kowey

  3. Lankenau Heart Institute, Thomas Jefferson University, Wynnewood, PA, USA

    Charles Antzelevitch

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Burashnikov, A., Antzelevitch, C. (2020). Mechanisms Underlying the Development of Cardiac Arrhythmias. In: Yan, GX., Kowey, P., Antzelevitch, C. (eds) Management of Cardiac Arrhythmias. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-030-41967-7_2

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  • DOI: https://doi.org/10.1007/978-3-030-41967-7_2

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