Abstract
Leiomyosarcoma is a rare malignant intraosseous neoplasm, comprising spindle cells showing smooth muscle differentiation and devoid of matrix production. It is most common in long bones of adults, especially the femur and tibia. Craniofacial bones and the spine are other preferred sites. It is radiologically osteolytic and permeative. It is histologically similar to its soft-tissue counterpart, with long and interwoven bundles of spindle cells with eosinophilic cytoplasm and characteristic blunt-ended nuclei. It is positive for smooth muscle immunohistochemical markers. Histologic grade correlates with prognosis. Combined surgical resection and chemotherapy are indicated.
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Kalil, R.K. (2020). Leiomyosarcoma of Bone. In: Santini-Araujo, E., Kalil, R.K., Bertoni, F., Park, YK. (eds) Tumors and Tumor-Like Lesions of Bone. Springer, Cham. https://doi.org/10.1007/978-3-030-28315-5_43
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DOI: https://doi.org/10.1007/978-3-030-28315-5_43
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