Abstract
Ampulla of Vater and Head of Pancreas Carcinomas: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of tumours and TNM8 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the more common non-carcinoma malignancies that are encountered at this site in diagnostic practice.
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Notes
- 1.
A high power field equating to 0.2 mm2 (10hpfs = 2 mm2)
- 2.
The European Neuroendocrine Tumour Society (ENETS) designates pancreatic neuroendocrine tumours as: pT1 < 2 cm (less than 5 mm = microadenoma/benign), pT2 > 2 cm and ≤ 4 cm, pT3 > 4 cm, pT4 invading adjacent large vessels or stomach, spleen, colon or adrenal gland. The ENETS TNM staging system is endorsed by The Royal College of Pathologists
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Kelly, P.J. (2020). Ampulla of Vater and Head of Pancreas Carcinomas. In: Boyle, D., Allen, D. (eds) Histopathology Reporting. Springer, Cham. https://doi.org/10.1007/978-3-030-27828-1_4
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