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Regulatory Roles of HSP90-Rich Extracellular Vesicles

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

Abstract

HSP90 is an essential protein in protein folding, cancer progression and wound healing. Originally, most studies were focused on the intracellular molecular chaperone role of HSP90. However, more recent studies, including ours, have reported the secretion of HSP90 and novel functions for this protein in the extracellular space (ex-HSP90). Additionally, HSP90 has been found to be a major cargo contained in extracellular vesicles (EV) such as exosomes. HSP90 can directly bind to and promote functions of CD91/LRP1 and receptor tyrosine kinases such as EGF receptor. HSP90 also regulates the recycling of Rab proteins that control the secretion of exosomes. This chapter reviews current knowledge and the future potential of ex-HSP90 and EV-HSP90.

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Abbreviations

ECM:

Extracellular matrix

EGFR:

Epidermal growth factor receptor

EMT:

Epithelial-mesenchymal transition

EV:

Extracellular vesicle

ex-HSP90:

Extracellular HSP90

FN:

Fibronectin

HIF-1:

Hypoxia-inducible factor-1

HNC:

Head and neck cancer

HSP:

Heat shock protein

ic-HSP90:

Intracellular HSP90

LRP1:

Lipoprotein receptor-related protein 1

MV:

Microvesicle

MVB:

Multivesicular body

OSCC:

Oral squamous cell carcinoma

RTK:

Receptor tyrosine kinase

TM:

Transmembrane

TSP1:

Thrombospondin 1

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Acknowledgements

This paper is dedicated to the memory of one of our mentors, Professor Ken-ichi Kozaki, who passed away on May 29, 2016. The authors thank Yuka Okusha, Chiharu Sogawa, Masaharu Takigawa, Sati Kubota, Akira Sasaki, Ayesha Murshid, Thomas Prince, and Benjamin Lang for useful discussion and helpful suggestion. This work was supported by JSPS KAKENHI, grant numbers JP17K11642 (TE), JP17K11643 (TE), JP17K11669 (TE), JP16K11863 (KOk), JP18K09789 (TE) and by SUZUKEN memorial foundation (TE).

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Authors and Affiliations

  1. Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

    Takanori Eguchi, Kisho Ono & Kuniaki Okamoto

  2. Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

    Takanori Eguchi

  3. Department of Oral and Maxillofacial Surgery, Okayama University Hospital, Okayama, Japan

    Kisho Ono

  4. Department of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

    Kazumi Kawata

  5. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Stuart K. Calderwood

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  1. Takanori Eguchi
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  5. Stuart K. Calderwood
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Correspondence to Takanori Eguchi .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Eguchi, T., Ono, K., Kawata, K., Okamoto, K., Calderwood, S.K. (2019). Regulatory Roles of HSP90-Rich Extracellular Vesicles. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_1

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