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Diagnosis and Prevention of Atopic Eczema

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Preventive Dermatology
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Abstract

Atopic eczema (AE) is a chronic, highly prevalent, inflammatory skin disease with a characteristic phenotype and distribution pattern. A variety of terms have been created to describe this characteristic phenotype. The historic terms “neurodermitis” and “neurodermatitis ”1 were replaced later by the term “atopic dermatitis ” and finally “AE. ”2 The term AE will be used in this chapter because it is the proposed term in the World Allergy Organization (WAO) guideline of 2004.2 AE often occurs together with allergic rhinoconjunctivitis and bronchial asthma. These three entities are referred to as “atopic diseases” or “allergic diseases.” The atopic diseases have the highest levels of incidence in the first decades of life.3 Typically, AE is the earliest symptom in the life of infants, then continues to allergic rhinoconjunctivitis and, finally, ends with allergic bronchial asthma. The term “atopic march” was coined for this natural course of the disease complex.4

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References

  1. Novak N, Bieber T, et al Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112(6 suppl):S128–S139

    Article  PubMed  CAS  Google Scholar 

  2. Johansson SG, Bieber T, et al Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832–836

    Article  PubMed  CAS  Google Scholar 

  3. Hamelmann E, Beyer K, et al Primary prevention of allergy: avoiding risk or providing protection? Clin Exp Allergy. 2008;38(2):233–245

    Article  PubMed  CAS  Google Scholar 

  4. Illi S, von Mutius E, et al The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113(5):925–931

    Article  PubMed  Google Scholar 

  5. Asher MI, Montefort S, et al Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006; 368(9537):733–743

    Article  PubMed  Google Scholar 

  6. Van Eerdewegh P, Little RD, et al Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002;418(6896):426–430

    Article  PubMed  CAS  Google Scholar 

  7. Prescott SL. Allergy: the price we pay for cleaner living? Ann Allergy Asthma Immunol. 2003;90(6 suppl 3):64–70

    Article  PubMed  Google Scholar 

  8. Liu AH. Hygiene theory and allergy and asthma prevention. Paediatr Perinat Epidemiol. 2007;21(suppl 3):2–7

    Article  PubMed  Google Scholar 

  9. Ring J, Krämer U, et al A critical approach to the hygiene hypothesis. Clin Exp Allergy Rev. 2004;4(suppl 2):40–44

    Article  Google Scholar 

  10. Jovanovic S, Felder-Kennel A, et al Exposition und Sensibilisierung gegenüber Milben- und Katzenallergenen bei Kindern in Baden-Württemberg. Gesundheitswesen. 2003;65(7):457–463

    Article  PubMed  CAS  Google Scholar 

  11. Cork M, Murphy R, et al The rising prevalence of atopic eczema and environmental trauma to the skin. Dermatol Pract. 2002;10(3):22–26

    Google Scholar 

  12. Cork MJ, Robinson DA, et al New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol. 2006;118(1):3–21

    Article  PubMed  CAS  Google Scholar 

  13. Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 1983;80 suppl:44s–49s

    Article  CAS  Google Scholar 

  14. Taïeb A. Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Derm. 1999;41(4):177–180

    Article  PubMed  Google Scholar 

  15. Holleran WM, Takagi Y, et al Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 2006;580(23):5456–5466

    Article  PubMed  CAS  Google Scholar 

  16. Chiou YB, Blume-Peytavi U. Stratum corneum maturation. Skin Pharmacol Physiol. 2004;17(2):57–66

    Article  PubMed  CAS  Google Scholar 

  17. Palmer CN, Irvine AD, et al Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–446

    Article  PubMed  CAS  Google Scholar 

  18. Baurecht H, Irvine AD, et al Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J Allergy Clin Immunol. 2007;120:1406–1412

    Article  PubMed  CAS  Google Scholar 

  19. Lebman DA, Coffman RL. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J Exp Med. 1988;168(3):853–862

    Article  PubMed  CAS  Google Scholar 

  20. Maintz L, Novak N. Getting more and more complex: the pathophysiology of atopic eczema. Eur J Dermatol. 2007; 17(4):267–283

    PubMed  CAS  Google Scholar 

  21. Hamid Q, Boguniewicz M, et al Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest. 1994;94(2):870–876

    Article  PubMed  CAS  Google Scholar 

  22. Larché M, Akdis CA, et al Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006;6(10):761–771

    Article  PubMed  CAS  Google Scholar 

  23. Verhagen J, Akdis M, et al Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol. 2006;117(1):176–183

    Article  PubMed  CAS  Google Scholar 

  24. Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113(5):805–819; quiz 820

    Article  PubMed  CAS  Google Scholar 

  25. Scalabrin DM, Bavbek S, et al Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. J Allergy Clin Immunol. 1999; 104(6):1273–1279

    Article  PubMed  CAS  Google Scholar 

  26. Werfel T, Ballmer-Weber B, et al Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA²LEN. Allergy. 2007;62(7):723–728

    Article  PubMed  CAS  Google Scholar 

  27. Mothes N, Niggemann B, et al The cradle of IgE autoreactivity in atopic eczema lies in early infancy. J Allergy Clin Immunol. 2005;116(3):706–709

    Article  PubMed  CAS  Google Scholar 

  28. Scheynius A, Johansson C, et al Atopic eczema/dermatitis syndrome and Malassezia. Int Arch Allergy Immunol. 2002; 127(3):161–169

    Article  PubMed  CAS  Google Scholar 

  29. Greaves MW. Recent advances in pathophysiology and current management of itch. Ann Acad Med Singap. 2007;36(9): 788–792

    PubMed  Google Scholar 

  30. Schmid-Ott G, Jaeger B, et al Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls. J Allergy Clin Immunol. 2001;108(3):455–462

    Article  PubMed  CAS  Google Scholar 

  31. Rukwied R, Lischetzki G, et al Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br J Dermatol. 2000;142(6): 1114–1120

    Article  PubMed  CAS  Google Scholar 

  32. Badertscher K, Bronnimann M, et al Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis. Arch Dermatol Res. 2005;296(10):503–506

    Article  PubMed  CAS  Google Scholar 

  33. Järvikallio A, Harvima IT, et al Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. Arch Dermatol Res. 2003;295(1):2–7

    PubMed  Google Scholar 

  34. Raap U, Werfel T, et al Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy. 2006;61(12): 1416–1418

    Article  PubMed  CAS  Google Scholar 

  35. Dillon SR, Sprecher C, et al Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004;5(7):752–760

    Article  PubMed  CAS  Google Scholar 

  36. Bilsborough J, Leung DY, et al IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol. 2006;117(2):418–425

    Article  PubMed  CAS  Google Scholar 

  37. Abeck D, Mempel M. Kutane Staphylococcus aureus Besiedelung des atopischen Ekzems. Hautarzt. 1998;49(12): 902–906

    Article  PubMed  CAS  Google Scholar 

  38. Bogaert D, van Belkum A, et al Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children. Lancet. 2004;363(9424):1871–1872

    Article  PubMed  CAS  Google Scholar 

  39. Leyden JJ, Marples RR, et al Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol. 1974;90(5): 525–530

    Article  PubMed  CAS  Google Scholar 

  40. Novak N, Bieber T. Pathogenese des atopischen Ekzems. JDDG J Ger Soc Dermatol. 2005;3(12):994–1005

    Google Scholar 

  41. Bunikowski R, Mielke M, et al Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis. J Allergy Clin Immunol. 1999;103(1 Pt 1):119–124

    Article  PubMed  CAS  Google Scholar 

  42. Sonkoly E, Muller A, et al IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol. 2006;117(2):411–417

    Article  PubMed  CAS  Google Scholar 

  43. Ong PY, Ohtake T, et al Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;347(15):1151–1160

    Article  PubMed  CAS  Google Scholar 

  44. Howell MD, Wollenberg A, et al Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol. 2006;117(4):836–841

    Article  PubMed  CAS  Google Scholar 

  45. Schudel P, Wüthrich B. Klinische Verlaufsbeobachtungen bei Neurodermitis atopica nach dem Kleinkindesalter. Eine katamnestische Untersuchung anhand von 121 Fällen. H±G Zeitschrift für Hautkrankheiten. 1985;60(6):479–486

    CAS  Google Scholar 

  46. Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh). 1980;92 suppl:44s–47s.

    Google Scholar 

  47. Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003; 361(9352):151–160

    Article  PubMed  Google Scholar 

  48. Williams HC, Burney PG, et al The U.K. Working Party’s Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131(3):383–396

    Article  PubMed  CAS  Google Scholar 

  49. Jøhnke H, Vach W, et al A comparison between criteria for diagnosing atopic eczema in infants. Br J Dermatol. 2005; 153(2):352–358

    Article  PubMed  Google Scholar 

  50. Lewis-Jones S, Mugglestone MA. Management of atopic eczema in children aged up to 12 years: summary of NICE guidance. Bmj. 2007;335(7632):1263–1264

    Article  PubMed  Google Scholar 

  51. Turjanmaa K, Darsow U, et al EAACI/GA²LEN position paper: present status of the atopy patch test. Allergy. 2006;61(12):1377–1384

    Article  PubMed  CAS  Google Scholar 

  52. Berni Canani R, Ruotolo S, et al Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. Allergy. 2007;62(7):738–743

    Article  PubMed  Google Scholar 

  53. Mehl A, Rolinck-Werninghaus C, et al The atopy patch test in the diagnostic workup of suspected food-related symptoms in children. J Allergy Clin Immunol. 2006; 118(4): 923–929

    Article  PubMed  Google Scholar 

  54. Niggemann B, Gruber C. Unproven diagnostic procedures in IgE-mediated allergic diseases. Allergy. 2004;59(8): 806–808

    Article  PubMed  CAS  Google Scholar 

  55. Stapel SO, Asero R, et al Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI task force report. Allergy. 2008;63(7):793–796

    Article  PubMed  CAS  Google Scholar 

  56. Darsow U, Lübbe J, et al Position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol. 2005;19(3):286–295

    Article  PubMed  CAS  Google Scholar 

  57. Smith FJ, Irvine AD, et al Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38(3):337–342

    Article  PubMed  CAS  Google Scholar 

  58. Lin SP, Huang SY, et al Netherton syndrome: mutation analysis of two Taiwanese families. Arch Dermatol Res. 2007;299(3):145–150

    Article  PubMed  Google Scholar 

  59. Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007;120(4):744–750

    Article  PubMed  CAS  Google Scholar 

  60. Lannerö E, Wickman M, et al Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respir Res. 2006;7:3

    Article  PubMed  Google Scholar 

  61. Muraro A, Dreborg S, et al Dietary prevention of allergic diseases in infants and small children. Part III: critical review of published peer-reviewed observational and interventional studies and final recommendations. Pediatr Allergy Immunol. 2004;15(4):291–307

    Article  PubMed  Google Scholar 

  62. Greer FR, Sicherer SH, et al Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008;121(1):183–191

    Article  PubMed  Google Scholar 

  63. Akdis CA, Akdis M, et al Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118(1):152–169

    Article  PubMed  Google Scholar 

  64. Akdis CA, Akdis M, et al Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Allergy. 2006;61(8):969–987

    Article  PubMed  CAS  Google Scholar 

  65. Lowe LA, Woodcock A, et al Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2004;158(10):996–1001

    Article  PubMed  Google Scholar 

  66. Svanes C, Zock JP, et al Do asthma and allergy influence subsequent pet keeping? An analysis of childhood and adulthood. J Allergy Clin Immunol. 2006;118(3):691–698

    Article  PubMed  Google Scholar 

  67. Sporik R, Ingram JM, et al Association of asthma with serum IgE and skin test reactivity to allergens among children living at high altitude. Tickling the dragon’s breath. Am J Respir Crit Care Med. 1995;151(5):1388–1392

    PubMed  CAS  Google Scholar 

  68. von Mutius E, Weiland SK, et al Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet. 1998;351(9106):862–866

    Article  Google Scholar 

  69. Flöistrup H, Swartz J, et al Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol. 2006;117(1):59–66

    Article  PubMed  Google Scholar 

  70. Ventura MT, Munno G, et al Allergy, asthma and markers of infections among Albanian migrants to Southern Italy. Allergy. 2004;59(6):632–636

    Article  PubMed  CAS  Google Scholar 

  71. van den Biggelaar AH, Rodrigues LC, et al Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis. 2004;189(5): 892–900

    Article  PubMed  Google Scholar 

  72. Flood JM, Weinstock HS, et al Neurosyphilis during the AIDS epidemic, San Francisco, 1985–1992. J Infect Dis. 1998;177(4):931–940

    Article  PubMed  CAS  Google Scholar 

  73. Kalliomaki M, Salminen S, et al Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001;357(9262):1076–1079

    Article  PubMed  CAS  Google Scholar 

  74. Kalliomaki M, Salminen S, et al Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003;361(9372):1869–1871

    Article  PubMed  Google Scholar 

  75. Kalliomaki M, Salminen S, et al Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(4):1019–1021

    Article  PubMed  Google Scholar 

  76. Niederberger V, Valenta R. Molecular approaches for new vaccines against allergy. Expert Rev Vaccines. 2006;5(1):103–110

    Article  PubMed  CAS  Google Scholar 

  77. Niederberger V, Horak F, et al Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci USA. 2004;101(suppl 2): 14677–14682

    Article  PubMed  CAS  Google Scholar 

  78. Niggemann B, Jacobsen L, et al Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006;61(7):855–859

    Article  PubMed  CAS  Google Scholar 

  79. Jacobsen L, Niggemann B, et al Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy. 2007;62(8): 943–948

    Article  PubMed  CAS  Google Scholar 

  80. Bussmann C, Maintz L, et al Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study. Clin Exp Allergy. 2007;37(9): 1277–1285

    Article  PubMed  CAS  Google Scholar 

  81. Werfel T, Breuer K, et al Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study. Allergy. 2006;61(2):202–205

    Article  PubMed  CAS  Google Scholar 

  82. Abramovits W, Boguniewicz M. A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults. J Drugs Dermatol. 2006;5(3):236–244

    PubMed  Google Scholar 

  83. Hanifin JM, Cooper KD, et al Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association “Administrative Regulations for Evidence-Based Clinical Practice Guidelines”. J Am Acad Dermatol. 2004;50(3):391–404

    Article  PubMed  Google Scholar 

  84. Hoare C, Li Wan Po A, et al Systematic review of treatments for atopic eczema. Health Technol Assess. 2000;4(37):1–191

    PubMed  CAS  Google Scholar 

  85. Van Der Meer JB, Glazenburg EJ, et al The management of moderate to severe atopic dermatitis in adults with topical fluticasone propionate. The Netherlands Adult Atopic Dermatitis Study Group. Br J Dermatol. 1999;140(6): 1114–1121

    Google Scholar 

  86. Wollenberg A, Bieber T. Proactive therapy of atopic dermatitis – an emerging concept. Allergy. 2009;64(2):276–278

    Article  PubMed  CAS  Google Scholar 

  87. Ashcroft DM, Dimmock P, et al Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials. BMJ. 2005;330(7490):516

    Article  PubMed  CAS  Google Scholar 

  88. Luger T, Van Leent EJ, et al SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. Br J Dermatol. 2001;144(4):788–794

    Article  PubMed  CAS  Google Scholar 

  89. Thaçi D, Salgo R. The topical calcineurin inhibitor pimecrolimus in atopic dermatitis: a safety update. Acta Dermatovenerol Alp Panonica Adriat. 2007;16(2):58, 60–62

    PubMed  Google Scholar 

  90. Berger TG, Duvic M, et al The use of topical calcineurin inhibitors in dermatology: safety concerns. Report of the American Academy of Dermatology Association Task Force. J Am Acad Dermatol. 2006;54(5):818–823

    Article  PubMed  Google Scholar 

  91. Remitz A, Harper J, et al Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Acta Derm Venereol. 2007;87(1):54–61

    Article  PubMed  CAS  Google Scholar 

  92. Ring J, Abraham A, et al Control of atopic eczema with pimecrolimus cream 1% under daily practice conditions: results of a >2000 patient study. J Eur Acad Dermatol Venereol. 2008;22(2):195–203

    PubMed  CAS  Google Scholar 

  93. Ricci G, Patrizi A, et al Use of textiles in atopic dermatitis: care of atopic dermatitis. Curr Probl Dermatol. 2006;33:127–143

    Article  PubMed  CAS  Google Scholar 

  94. Rerinck HC, Kamann S, et al Eczema herpeticum: Pathogenese und Therapie. Hautarzt. 2006;57(7):586–591

    Article  PubMed  CAS  Google Scholar 

  95. Kelsay K. Management of sleep disturbance associated with atopic dermatitis. J Allergy Clin Immunol. 2006;118(1): 198–201

    Article  PubMed  Google Scholar 

  96. Schmitt J, Schmitt N, et al Cyclosporin in the treatment of patients with atopic eczema – a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2007;21(5): 606–619

    PubMed  CAS  Google Scholar 

  97. Schmitt J, Schakel K, et al Systemic treatment of severe atopic eczema: a systematic review. Acta Derm Venereol. 2007;87(2):100–111

    Article  PubMed  CAS  Google Scholar 

  98. Behnam SM, Behnam SE, et al Review of cyclosporine immunosuppressive safety data in dermatology patients after two decades of use. J Drugs Dermatol. 2005;4(2): 189–194

    PubMed  Google Scholar 

  99. Wise M, Callen JP. Azathioprine: a guide for the management of dermatology patients. Dermatol Ther. 2007; 20(4):206–215

    Article  PubMed  Google Scholar 

  100. Heymann WR. Antipsoriatic biologic agents for the treatment of atopic dermatitis. J Am Acad Dermatol. 2007;56(5): 854–855

    Article  PubMed  Google Scholar 

  101. National Institute for Health and Clinical Excellence. NICE guidance. At: <http://www.nice.org.uk/search/searchresults.jsp?keywords=eczema&searchType=all>; 2009 Accessed 04.04.09

  102. Staab D, Diepgen TL, et al Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial. BMJ. 2006;332(7547):933–938

    Article  PubMed  Google Scholar 

  103. Chida Y, Steptoe A, et al The effects of psychological intervention on atopic dermatitis. A systematic review and meta-analysis. Int Arch Allergy Immunol. 2007;144(1):1–9

    Article  PubMed  Google Scholar 

  104. Ersser SJ, Latter S, et al Psychological and educational interventions for atopic eczema in children. Cochrane Database Syst Rev. 2007;(3):CD004054

    Google Scholar 

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Wöhrl, S. (2011). Diagnosis and Prevention of Atopic Eczema. In: Norman, R. (eds) Preventive Dermatology. Springer, London. https://doi.org/10.1007/978-1-84996-021-2_13

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