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Macromolecular Delivery Across the Blood–Brain Barrier

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Macromolecular Drug Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 480))

Summary

The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood–brain barrier (BBB). Noninvasive, transient, and local image-guided blood–brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.

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Acknowledgments

Sources of support: NIH (grant numbers EB00705 and EB003268), and the Terry Fox Foundation.

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Authors and Affiliations

  1. Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada

    Kullervo Hynynen

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  1. Kullervo Hynynen
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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Hynynen, K. (2009). Macromolecular Delivery Across the Blood–Brain Barrier. In: Belting, M. (eds) Macromolecular Drug Delivery. Methods in Molecular Biology, vol 480. Humana Press. https://doi.org/10.1007/978-1-59745-429-2_13

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    • DOI: https://doi.org/10.1007/978-1-59745-429-2_13

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    • Publisher Name: Humana Press

    • Print ISBN: 978-1-58829-999-4

    • Online ISBN: 978-1-59745-429-2

    • eBook Packages: Springer Protocols

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