Abstract
Murine models of allograft transplantation are valuable for understanding the immunological mechanisms of allograft acceptance and rejection, the evaluation of immunosuppressive drugs and strategies, and the restoration of functional defects. Herein, we describe methods to create a skin murine allograft surgical model and how to administer adipose-derived stromal cells (ASC) with limited numbers of donor bone marrow to create stable multilineage donor cell chimerism and indefinite immunological tolerance.
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Foster, A.D., Clark, N., Davis, T.A. (2018). Induction of Skin Allograft Transplantation Tolerance in Mice Using Human Adipose Derived Stromal Cells. In: Bunnell, B.A., Gimble, J.M. (eds) Adipose-Derived Stem Cells. Methods in Molecular Biology, vol 1773. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7799-4_7
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DOI: https://doi.org/10.1007/978-1-4939-7799-4_7
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7797-0
Online ISBN: 978-1-4939-7799-4
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