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Vitamin D and Breast Cancer

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Vitamin D

Part of the book series: Nutrition and Health ((NH))

Abstract

During the last 15 years, it has become evident that the biologically most active form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], exerts effects on a variety of tissues apparently unrelated to calcium homeostasis. 1, 25(OH)2D3 has been shown to promote cellular differentiation and inhibit proliferation of hematopoietic cells, cancer cells, and keratinocytes. In addition, studies with animal models for cancer have shown that 1,25 (OH)2D3 administration can prolong the survival of leukemic mice and suppress the growth of tumors of different origin, including breast, colon, skin, and lung (1, 2).

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Authors
  1. Johannes P. T. M. van Leeuwen
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  2. Trudy Vink-van Wijngaarden
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  3. Huibert A. P. Pols
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  1. Boston University Medical Center, Boston, MA, USA

    Michael F. Holick PhD, MD

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van Leeuwen, J.P.T.M., Wijngaarden, T.Vv., Pols, H.A.P. (1999). Vitamin D and Breast Cancer. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_24

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  • DOI: https://doi.org/10.1007/978-1-4757-2861-3_24

  • Publisher Name: Humana Press, Totowa, NJ

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