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Reflux Nephropathy

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Pediatric Nephrology

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Abstract

“Reflux Nephropathy” is a term coined to encompass the spectrum of kidney disease forms in which vesico-ureteral reflux plays a major etiologic role; a group that has morbic anatomical changes with varying but distinctive features. Urinary infection and raised pressure within the urinary tract are commonly associated, but the ways in which those three etiologic factors combine to produce the differing disease entities is not yet established. The renal damage tends to commence at a very early age; and its more severe complications, severe hypertension and renal failure, are well documented from as young as five years onwards, the bulk of the clinical impact being between the ages of 10 and 30 years. Because the essence of the disease is severe focal fibrosis which strangles the parenchyma it enmeshes and which is largely unaffected by treatment once it has become established, the only hopeful method of approach, as in the case of cystic fibrosis, lies in early diagnosis and prevention rather than later amelioration or cure.

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Authors and Affiliations

  1. Diagnostic Radiol., Yale Univ. School of Medicine and Yale New Haven Hospital, New Haven, Conn., 06504, USA

    John Hodson M.D., F.R.C.P. (Lond.), F.R.C.R.

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  1. John Hodson M.D., F.R.C.P. (Lond.), F.R.C.R.
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  1. University of Miami School of Medicine, Miami, Florida, USA

    José Strauss

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© 1981 Plenum Press, New York

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Hodson, J. (1981). Reflux Nephropathy. In: Strauss, J. (eds) Pediatric Nephrology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8804-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-8804-3_6

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