Abstract
Cases of sequelae of cerebrovascular disease such as vascular dementia due to death of many neurons have been gradually increasing. Such neuronal death following brain ischemia has been considered to be due to energy deficiency resulting from an impaired respiratory chain. However, analysis of the delayed neuronal death showed that neuronal death is not caused by mere energy deficiency. Most studies on delayed neuronal death focused on the morphological changes and energy metabolism in the acute to subacute stage. There are few reports concerning biochemical changes in the chronic stage, especially in neurotransmitter receptors.
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References
Adams, J. H., Brierley, J. B., Connor R. C. T., and Triep, C., 1966, The effects of systemic hypotension on the human brain-Clinical and neuropahological observation in 11 cases, Brain, 89:235–254.
Benveniste, H., Drejer, J., Schousboe, A., and Diemer, N. H., 1984, Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43;1369–1374.
Brierley, J. B., and Cooper, J.E., 1962, Cerebral complecation of hypotensive anesthesia in a healthy adult, J. Neurol. Neurosing Psychiat., 25;24–30.
Kirino, T., 1982, Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res., 239; 57–69.
Murphy, D. E., Schneider, J., Boehm, C., Iehmann, J., and Williams, M., 1987, Binding of [ H]3-(2-carboxypiperazin-4-yl)propyl-l-phosphonic acid to rat brain membranes: A selective, high affinity ligand for N-methyl-D-aspartate receptors, J. Pharmacol. Exp. Ther., 240;778–784.
Ohkawa, H., Ohishi, N., and Yagi, K., 1976, A new sensitive assay for the measurement of hydroperoxide, Anal. Biochem., 76;184–191.
Ogawa, N., Haba, K., Yoshikawa, H., Ono, T., and Mizukawa, K., 1988, Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced depletion of brain acetylcholine levels in gerbils, Res. Commun. Chem. Pathol. Pharm., 61;285–288.
Ogawa, N., Mizuno, S., Nukina, I., Tsukamoto, S., and Mori, A., 1983, Chronic thyrotropin releasing hormone (TRH) administration on TRH receptors and muscarinic cholinergic receptors in CNS, Brain Res., 263;348–350.
Rothman, S. M., and Olney, J. W., 1986, Glutamate and the pathophysiology of hypoxic ischemic brain damage, Ann. Neurol., 19;105–111.
Suzuki, T., Yamaguchi, T., Kirino, T., Orzi, F., and Klatzo, I., 1983, The effects of 5-minutes ischemia in Mongolian gerbils I: blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes, Acta Neuropahol., 60;207–216.
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© 1991 Plenum Press, New York
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Ogawa, N., Haba, K., Asanuma, M., Mizukawa, K., Mori, A. (1991). Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_28
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DOI: https://doi.org/10.1007/978-1-4684-5907-4_28
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