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Clinical Implications of Immunity to Oncogenic Viruses

  • Chapter
Contemporary Topics in Immunobiology

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 6))

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Abstract

The evidence pointing to a viral etiology for at least some forms of human cancer, a possibility that has long been considered on the basis of animal studies, has continued to accumulate to such an extent that viral oncologists must now reevaluate their clinical and experimental data in order to consider which specific approaches are now ready for clinical trials. Although ethical restrictions continue to inhibit attempts to prove that specific viruses cause certain human tumors, as outlined by Bryan et al. (1967; Bryan, 1962), epidemiological studies have been able to suggest not only which human tumors are most likely to be caused by infectious agents (Burkitt, 1962; Cole et al., 1968; Correa and O’Conor, 1971; Heath and Hasterlik, 1963; Kessler, 1974; Levine, 1974; Levine and Gravell, 1975; Morrow et al., 1971) but some have even suggested the pattern of the agents’ transmission (Kessler, 1976; Vianna et al., 1971).

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Paul H. Levine

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  1. Basic Research Program, NCI Frederick Cancer Research Center, Frederick, Maryland, 21701, USA

    Michael G. Hanna Jr.

  2. Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 17033, USA

    Fred Rapp

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© 1977 Plenum Press, New York

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Levine, P.H. (1977). Clinical Implications of Immunity to Oncogenic Viruses. In: Hanna, M.G., Rapp, F. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3051-6_10

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  • DOI: https://doi.org/10.1007/978-1-4684-3051-6_10

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