Abstract
Neutron capture events occurring in the cell nucleus associated with genetic material should be highly lethal.1,2 We and others have prepared a variety of boronated nucleic acid derivatives or DNA binding boronated ligands toward achieving this goal.3 Approaches we have used include synthesis of nucleosides with N-boronated bases4 and (oligo)nucleotides with boronation on the phosphodiester backbone.5 Previously, we reported that the radiolabeled [2-14C]2’-deoxycytidine-N3-cyanoborane was taken up much faster in leukemic Tmolt3 cells than in rapidly dividing non-tumorous human Bg-9 fibroblasts.6 Evidence was also reported for a greater percentage of binding or incorporation into the DNA and RNA of cancer cells than in non-cancer cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T. Kobayashi and K. Kanda, Analytical calculation of boron-10 dosage in cell nucleus for neutron capture therapy, Radiat. Res. 91:71 (1982).
D. Gabel, S. Foster, and R.G. Fairchild, The Monte-Carlo simulation of the biological effect of the 10B(nα)7Li reaction in cells and tissue and its implication for boron neutron capture therapy, Radiat. Res. 111:14 (1987).
B.J. Allen, D.E. Moore, and B.V. Harrington, Eds., “Progress in Neutron Capture Therapy for Cancer” Plenum Press. New York (1992). See articles on pps 207, 211, 219 and 231 and references therein.
A. Sood, B.R. Shaw, and B.F. Spielvogel, Boron containing nucleic acids: Synthesis of cyanoborane adducts of 2’-eoxynucleosides, J. Amer. Chem. Soc. 111:9234 (1989).
A. Sood, B.R. Shaw, and B.F. Spielvogel, Boron containing nucleic acids 2: Synthesis of oligodeoxynucleoside boranophosphates, J. Amer. Chem. Soc. 112:9000 (1990).
A. Sood, B.F. Spielvogel, B.R. Shaw, L.D. Carlton, B.S. Burnham, E.S. Hall, and I.H. Hall, The synthesis and antineoplastic activity of 2’ deoxynucleoside-cyanoboranes in murine and human culture cells, Anti Cancer Res. 12:335 (1992).
J. Tomasz, B.R. Shaw, K. Porter, B.F. Spielvogel, and A. Sood, 5’-P-Boranesubstituted thymidine monophosphate and triphosphate. Angewandte Chemie. Int. Ed. 31:1373 (1992).
For a recent review, see S.T. Crooke, Therapeutic Applications of Oligonucleotides, Bio Technol. 10:882 (1992).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Spielvogel, B.F., Sood, A., Powell, W., Tomasz, J., Porter, K., Shaw, B.R. (1993). Chemical and Enzymatic Incorporation of Boron into DNA. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_80
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2978-1_80
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6296-8
Online ISBN: 978-1-4615-2978-1
eBook Packages: Springer Book Archive