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Transsphenoidal Surgery for Cushing’s Disease

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Cushing’s Syndrome

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Abstract

Transsphenoidal resection of an adrenocorticotrophic hormone (ACTH)-secreting pituitary adenoma has the potential to cure most patients with Cushing’s disease (CD). Cure rates following surgery range from 20–90%, depending upon the institution, the accuracy of the pro-operative diagnosis, and the experience of the surgeon. Although diagnostic methods for defining a pituitary adenoma have improved in the past several decades, there remain challenges in the surgical management of these tumors. This chapter will focus on the indications for surgery, preoperative and intraoperative evaluation and surgical management of these tumors, outcome of surgery in the microsurgical era, potential complications, management of persistent or recurrent tumor, and long-term outcome with surgery.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Vanderbilt University School of Medicine, Nashville, TN, USA

    Robert J. Weil M.D. & George S. Allen M.D., PhD.

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  1. Robert J. Weil M.D.
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  2. George S. Allen M.D., PhD.
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Editor information

Editors and Affiliations

  1. The Pituitary Center at Vanderbilt, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lewis S. Blevins Jr. M.D. (Associate Professor of Medicine & Neurological Surgery) (Associate Professor of Medicine & Neurological Surgery)

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© 2002 Springer Science+Business Media New York

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Weil, R.J., Allen, G.S. (2002). Transsphenoidal Surgery for Cushing’s Disease. In: Blevins, L.S. (eds) Cushing’s Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1103-8_11

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  • DOI: https://doi.org/10.1007/978-1-4615-1103-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5396-6

  • Online ISBN: 978-1-4615-1103-8

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