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Relationship of GW/P-Bodies with Stress Granules

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Ten Years of Progress in GW/P Body Research

Part of the book series: Advances in Experimental Medicine and Biology ((volume 768))

Abstract

Whereas P-bodies are intimately linked to the cytoplasmic RNA decay machinery, stress granules harbor stalled translation initiation complexes that accumulate upon stress-induced translation arrest. In this Chapter, we reflect on the relationship between P-bodies and stress granules. In mammalian cells, the two structures can be clearly distinguished from each other using specific protein or RNA markers, but they also share many proteins and mRNAs. While the formation of P-bodies and stress granules is coordinately triggered by stress, their assembly appears to be regulated independently by different pathways. Under certain types of stress, P-bodies frequently dock with stress granules, and overexpressing certain proteins that localize to both structures can cause P-body/stress granule fusion. Currently available data suggest that these self-assembling compartments are controlled by flux of mRNAs within the cytoplasm, and that their assembly mirrors the translation and degradation rates of their component mRNAs.

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Acknowledgments

This work was supported by young investigator grant HZ-NG-210 from the Helmholtz Gemeinschaft, and RO1 AI 033600 from the National Institutes of Health.

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Authors and Affiliations

  1. Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Georg Stoecklin

  2. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA, 02115, USA

    Nancy Kedersha

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  1. Georg Stoecklin
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  2. Nancy Kedersha
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Correspondence to Georg Stoecklin .

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Editors and Affiliations

  1. College of Dentistry, Department of Oral Biology, University of Florida, Southwest Archer Road 1600, Gainesville, 32610, Florida, USA

    Edward K. L. Chan

  2. Dept. Medicine & Medical Biochemistry, University of Calgary, Hospital Drive NW., 3330, Calgary, T2N 4N1, Alberta, Canada

    Marvin J. Fritzler

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Stoecklin, G., Kedersha, N. (2013). Relationship of GW/P-Bodies with Stress Granules. In: Chan, E., Fritzler, M. (eds) Ten Years of Progress in GW/P Body Research. Advances in Experimental Medicine and Biology, vol 768. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5107-5_12

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