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Role of Calcium in the Secretion of Atrial Natriuretic Peptide

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Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Atrial natriuretic peptide (ANP), a potent natriuretic, diuretic, and smooth muscle relaxant, is released from atrial cardiomyocytes in response to a variety of stimuli, such as atrial distension and tachycardia, and in response to various vasoconstrictors.1,2 Although ANP appears to be stored in secretory granules in the form of a pre-hormone and to be proteolytically cleaved only upon secretion,3 the functional morphology of these granules is analogous to that of other endocrine secretory tissues, which suggests that calcium may play a role in their release.4 Indeed, the heart possesses a number of complex mechanisms for regulating the concentration of intracellular calcium ([Ca]i). Most of them involve the release of Ca2+ from a large intracellular pool in the sarcoplasmic reticulum (SR), although extracellular calcium [Ca]0 may also play a role in contractile function.5,6

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References

  1. deBold AJ. Atrial natriuretic factor: A hormone produced by the heart. Science 1985; 230:767–770.

    Article  CAS  Google Scholar 

  2. Schiebinger RJ, Baker MZ, Linden J. Effect of adrenergic and muscarinic cholinergic agonists on atrial natriuretic peptide secretion by isolated rat atria. J Clin Invest 1987; 80:1687–1691.

    Article  PubMed  CAS  Google Scholar 

  3. Vulteenako O, Arjamaa O, Ling N. Atrial natriuretic polypeptides (ANP): Rat atria store high molecular weight precursor but secrete processed peptides of 25–35 amino acids. Biochem Biophys Res Comm 1985; 129:82–88.

    Article  Google Scholar 

  4. Rasmussen H. The calcium messenger system. N Engl J Med 1986; 314:1094–1101.

    Article  PubMed  CAS  Google Scholar 

  5. Morgan JP, Morgan KG. Calcium and cardiovascular function: Intracellular calcium levels during contraction and relaxation of mammalian cardiac and vascular smooth muscle as detected with aequorin. Am J Med 1984; 77:33–46.

    Article  PubMed  CAS  Google Scholar 

  6. Bers DM. Early transient depletion of extracellular Ca during individual cardiac muscle contraction. Am J Physiol 1986; 244:H462–H468.

    Google Scholar 

  7. Movsesian MA, Thomas AP, Selak M, Williamson JR. Inositol triphosphate does not release Ca++ from permeabilized cardiac myocytes and sarcoplasmic reticulum. FEBS Lett 1985; 185:328–332.

    Article  PubMed  CAS  Google Scholar 

  8. Laher I, Beban JA. Protein kinase C activation selectively augments a stretch-induced calcium dependent tone in vascular smooth muscle. J Pharmacol Exp Ther 1987; 242:566–572.

    PubMed  CAS  Google Scholar 

  9. Guharay F, Sachs F. Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol 1984; 352:685–701.

    PubMed  CAS  Google Scholar 

  10. Saito Y, Nakao K, Morii N, Sugawara A, Shiono S, Yamada T, Itoh H, Sakamoto M, Kurahashi K, Fujiwara M, Imura H. Bay K8644, a voltage-sensitive calcium channel agonist, facilitates secretion of atrial natriuretic polypeptide from isolated perfused rat hearts. Biochem Biophys Res Comm 1986; 138:1170–1176.

    Article  PubMed  CAS  Google Scholar 

  11. Ruskoaho H, Toth M, Lang RE. Atrial natriuretic peptide secretion: Synergistic effect of phorbol ester and A23187. Biochem Biophys Res Comm 1985; 133:581–588.

    Article  PubMed  CAS  Google Scholar 

  12. Ruskoaho H, Toth M, Ganten D, Unger T, Lang RE. The phorbol ester induced atrial natriuretic peptide secretion is stimulated by forskolin and Bay K8644 and inhibited by 8-bromo-cyclic GMP. Biochem Biophys Res Comm 1986; 139:266–274.

    Article  PubMed  CAS  Google Scholar 

  13. Ruskoaho H, Vuolteenaho O, Leppalluoto J. Phorbol esters enhance stretch-induced atrial natriuretic peptide secretion. Endocrinology 1990; 127:2445–2455.

    Article  PubMed  CAS  Google Scholar 

  14. Doubell AF. The effect of calcium antagonists on atrial natriuretic peptide (ANP) release from the rat heart during rapid cardiac pacing. J Mol Cell Cardiol 1989; 21:437–440.

    Article  PubMed  CAS  Google Scholar 

  15. Doubell AF. The second messenger system(s) mediating the secretion of atrial natriuretic peptide (ANP) from the isolated rat heart during rapid cardiac pacing. Life Sei 1989; 45:2193–2200.

    Article  CAS  Google Scholar 

  16. Ishida A, Tanakashi T, Okumura K, Hashimoto H, Ito T, Ogawa K, Satake T. A calmodulin antagonist (W-7) and a protein kinase C inhibitor (H-7) have no effect on atrial natriuretic peptide release induced by atrial stretch. Life Sei 1988; 42:1659–1667.

    Article  CAS  Google Scholar 

  17. Schiebinger RJ. Calcium, its role in isoproterenol-stimulated atrial natriuretic peptide secretion by superfused rat atria. Circ Res 1989; 65:600–606.

    PubMed  CAS  Google Scholar 

  18. Schiebinger RJ, Parr HG, Cragoe EJ Jr. Calcium: Its role in ax-adrenergic stimulation of atrial natriuretic peptide secretion. Endocrinology 1992; 130:1017–1023.

    Article  PubMed  CAS  Google Scholar 

  19. Schiebenger RJ, Gomez-Sanchez CE. Endothelin: A potent stimulus of atrial natriuretic peptide secretion by superfused rat atria and its dependency on calcium. Endocrinology 1990; 127:119–125.

    Article  Google Scholar 

  20. deBold ML, deBold AJ. Effect of manipulations of Ca++ environment on atrial natriuretic factor release. Am J Physiol 1989; 256:H1588–H1594.

    CAS  Google Scholar 

  21. Kuroski-deBold ML, deBold AJ. Stretch-secretion coupling in atrial cardiocytes: Dissociation between atrial natriuretic factor release and mechanical activity. Hypertension 1991; 18:111–169–111–178.

    Google Scholar 

  22. Page E, Goings GE, Power B, Upshaw-Earley J. Basal and stretch-augmented natriuretic peptide secretion by quiescent rat atria. Am J Physiol 1990; 259.-C801–C818.

    PubMed  CAS  Google Scholar 

  23. Page E, Upshaw-Earley J, Goings GE, Hanek DA. Effect of external Ca++ concentration on stretch-augmented natriuretic peptide secretion by rat atria. Am J Physiol 1991; 260:C756–C762.

    PubMed  CAS  Google Scholar 

  24. Matsubara H, Hirata Y, Yoshimi H, Takata S, Takagi Y, Umeda Y, Yamane Y, Inada M. Role of calcium and protein kinase C in ANP secretion by cultured rat cardiocytes. Am J Physiol 1988; 255:H405–H409.

    PubMed  CAS  Google Scholar 

  25. Hirata Y, Matsubara H, Fukuda Y, Yoshimi H. Cellular mechanisms of atrial natriuretic factor secretion by cultured rat cardiocytes. J Hypertension 1988; 6:S295–S296.

    CAS  Google Scholar 

  26. Greenwald JE, Apkon M, Hruska KA, Needleman P. Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium. J Clin Invest 1989; 83:1061–1065.

    Article  PubMed  CAS  Google Scholar 

  27. Uusimaa PA, Ruskoako H, Leppaluoto J, Hassinen IE. Cytosolic Ca++ during atrial natriuretic peptide secretion from cultured neonatal cardiomyocytes. Mol Cell Endocrinol 1990; 73:153–163.

    Article  PubMed  CAS  Google Scholar 

  28. Uusimaa PA, Hassinen IE, Vuolseenako O, Ruskoaho H. Endothelin-induced atrial natriuretic peptide release from cultured neonatal cardiac myocytes: the role of extracellular calcium and protein kinase C. Endocrinology 1992; 130:2455–2464.

    Article  PubMed  CAS  Google Scholar 

  29. Sei CA, Glembotski CC. Calcium dependence of phenylephrine-, endothelin-, and potassium chloride-stimulated atrial natriuretic factor secretion from long term primary neonatal rat atrial cardiocytes. J Biol Chem 1990; 265:7166 27172.

    PubMed  CAS  Google Scholar 

  30. Gardner DG, Wirtz H, Dobbs LG. Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes. Am J Physiol 1992; 263:E239–E244.

    PubMed  CAS  Google Scholar 

  31. LaPointe MC, Deschepper CF, Wu J, Gardner DG. Extracellular calcium regulates expression of the gene for atrial natriuretic factor. Hypertension 1990; 15:20–28.

    PubMed  CAS  Google Scholar 

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Authors
  1. Mary F. Walsh
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Editor information

Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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© 1994 Springer-Verlag New York, Inc.

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Walsh, M.F. (1994). Role of Calcium in the Secretion of Atrial Natriuretic Peptide. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_6

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

  • eBook Packages: Springer Book Archive

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