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Calcium Signals in Cell Proliferation, Differentiation, and Death

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

Abstract

Ca2+, the calcium ion, binding to surface sensor/receptors on the cell membrane, flowing through channels in the cell membrane, and/or surging from internal storage vesicles, “kick starts” and then drives cell cycles, triggers terminal differentiation, and ultimately kills senescent mature cells. This discussion will be divided into four parts: (1) the Ca2+ and associated signals, especially the cyclic AMP (cAMP) pulses, that start and then at several key points drive the proliferation of cells in the regenerating rat liver, a physiologically relevant wound-response model; (2) the dramatic liberation from Ca2+ control when liver cells start making Ca2+-binding/activated signal proteins in excess and secreting self-stimulating (autocrine) growth factors while on the way to malignancy; (3) the roles of Ca2+ and other signals that drive the proliferation, trigger terminal differentiation and finally the death of skin keratinocytes; and the factors that upset the normal delicate balance between Ca2+-driven proliferation, Ca2+-triggered differentiation, and Ca2+-induced death during skin carcinogenesis; and (4) the role of Ca2+ in the proliferation, differentiation, and death of colon cells and the possibility that the failure of a Ca2+-sensing mechanism might be the first step on the road to polyps and colon cancer.

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Authors
  1. James F. Whitfield
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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Whitfield, J.F. (1994). Calcium Signals in Cell Proliferation, Differentiation, and Death. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_2

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