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Chemokines

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 507 Accesses

Synonyms

Chemoattractant; Chemotactic proteins; Small cytokines

Chemokines: A General Definition

Chemokines are a large family of small chemotactic cytokines involved in many physiological processes, including development, angiogenesis, tissue organization, cell homing, and inflammation. Most of these functions are associated with cellular migration and directional movement in response to specific chemokine gradients. Chemokines are also important in cellular activation and cellular protection against damage. Chemokine signaling is mediated through interactions with 7-transmembrane, G protein-coupled receptors that subsequently results in the diverse functions described above. Dysregulation of chemokine secretion directly participates in the pathogenesis of many diseases, by altering inflammation, cell survival, homeostasis, resolution of injury, migration of stem or hematopoietic cells, cellular differentiation, and scar formation as well as by global regulation of the immune...

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Author information

Authors and Affiliations

  1. Public Health Research Institute (PHRI), UMDNJ, Newark, NJ, USA

    Eliseo A. Eugenin

  2. Department of Microbiology and Molecular Genetics, UMDNJ, Newark, NJ, USA

    Eliseo A. Eugenin

  3. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Joan W. Berman

  4. Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Joan W. Berman

Authors
  1. Eliseo A. Eugenin
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  2. Joan W. Berman
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Corresponding author

Correspondence to Eliseo A. Eugenin .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Eugenin, E.A., Berman, J.W. (2014). Chemokines. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_34

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_34

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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