Definition
The dysembryoplastic neuroepithelial tumor (DNET) is an uncommon tumor characterized by a heterogeneous population of neurons, astrocytes, and oligodendroglia-like cells (OLCs). It arises within the supratentorial cortex and is almost always associated with partial complex seizures. The DNET presents as a focal lesion, most commonly found in the temporal lobe. It may appear cystic and show one of three characteristics, including a specific glioneuronal element, nodular component, or association with cortical dysplasia. The basic nature of the DNET and its constituent cells, particularly the OLCs, has remained undetermined; and, confusion as to the classification and differential diagnosis of the lesion, that is, whether DNETs are malformations or neoplasms has existed. However, since DNETs arise from the secondary germinal layer of the developing nervous system and may develop to a sizable mass characterized by an excessive proliferation of cells, they are...
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References and Readings
Kleihues, P., Burger, P. D., & Scheithauer, B. W. (1993). Histological typing of tumors of the central nervous system(2nd ed.). New York: Springer.
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Cunningham, J.L. (2011). Dysembryoplastic Neuroepithelial Tumor. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79948-3_104
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DOI: https://doi.org/10.1007/978-0-387-79948-3_104
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