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Muscarinic Acetylcholine Receptor

  • Reference work entry
Handbook of Neurochemistry and Molecular Neurobiology

Abstract

Muscarinic acetylcholine receptors (muscarinic receptors) are prototypical G protein-coupled receptors (GPCRs) activated by the endogenous neurotransmitter acetylcholine and play key roles in regulating the activity of many vital functions of the central and peripheral nervous systems. Studies of muscarinic receptors as well as rhodopsin and β adrenergic receptors have revealed several characteristics of GPCRs, which are also true for other GPCRs. Here, we present an overview of the historical background and current studies of muscarinic receptors focusing on studies carried out in our laboratory.

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Abbreviations

AC:

adenylyl cyclase

AKAP:

cAMP-dependent protein kinase anchoring protein

GAP:

GTPase-activating protein

GPCR:

G protein-coupled receptor

GRK:

G protein-coupled receptor kinase

i2:

second intracellular loop

i3:

third intracellular loop

IP3 :

inositol-1,4,5-trisphosphate

KO:

knockout

NMR:

nuclear magnetic resonance

PKA:

cAMP-dependent protein kinase

PKC:

protein kinase C

PLC:

phospholipase C

RGS:

regulators of G protein signaling

RH:

regulator of G protein signaling homology

TM:

transmembrane

TRPC6:

transient receptor potential-canonical subtype

WT:

wild-type

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Acknowledgment

We thank Dr. Hiroyuki Nakamura (Gakushuin Univ.) for his support in performing the docking simulation of acetylcholine into the M3 receptor model.

Authors
  1. S. Ichiyama
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  2. T. Haga
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Group Director of Neuro-Developmental Disorder Research Group, RIKEN Brain Science Institute, 351-0198, 2-1 Hirosawa Wako-shi, Saitama, Japan

    Katsuhiko Mikoshiba

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Ichiyama, S., Haga, T. (2009). Muscarinic Acetylcholine Receptor. In: Lajtha, A., Mikoshiba, K. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30370-3_23

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