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Prevalence of hyperthyrotropinemia in obese children before and after weight loss

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Abstract

Background

Obesity is a worldwide epidemic. In recent years, increasing attention has been focused on thyroid function in obesity.

Objectives

To establish the prevalence of elevated thyroid-stimulating hormone (TSH) levels in obese children and adolescents, and identify the relationship between TSH levels and other metabolic and hormonal variables before and after weight reduction.

Materials and methods

We evaluated 150 obese subjects (aged 3–17 years) for anthropometric, biochemical, metabolic and hormonal variables. Measurements were taken at baseline and, in a subgroup of children with hyperthyrotropinemia, after a 6-month intervention program based on exercise, behavior therapy, and nutrition education.

Results

At baseline, 23 participants (15.3 %) had hyperthyrotropinemia, and 21 of these patients completed the weight reduction intervention. Among these 21 patients, 14 had substantial weight loss and a significant decrease in TSH and free T3 levels.

Conclusion

We conclude that TSH and T3 levels are significantly increased in childhood obesity; in most cases, however, these increases cannot be elucidated by thyroid autoimmunity or iodine deficiency. If thyroid disorders are excluded beforehand, an elevated TSH with normal thyroid hormone levels in obese children seems rather a consequence than a cause of obesity since weight loss leads to a normalization of elevated TSH levels. In this context, thyroid hormone alterations in obesity suggest an adaptation process.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Clinics of Pediatric Endocrinology, Dr. Sami Ulus Women Health, Children’s Education and Research Hospital, Ankara, Turkey

    Veysel Nijat Baş, Zehra Aycan, Sebahat Yılmaz Ağladıoğlu & Havva Nur Peltek Kendirci

Authors
  1. Veysel Nijat Baş
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  2. Zehra Aycan
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  3. Sebahat Yılmaz Ağladıoğlu
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  4. Havva Nur Peltek Kendirci
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Correspondence to Veysel Nijat Baş.

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Baş, V.N., Aycan, Z., Ağladıoğlu, S.Y. et al. Prevalence of hyperthyrotropinemia in obese children before and after weight loss. Eat Weight Disord 18, 87–90 (2013). https://doi.org/10.1007/s40519-013-0008-0

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  • DOI: https://doi.org/10.1007/s40519-013-0008-0

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