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Proteinuria rebound in IgA nephropathy associated with obesity-related glomerulopathy

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Abstract

IgA nephropathy (IgAN), the most prevalent primary chronic glomerulonephritis worldwide, has three major risk factors: hypertension, proteinuria >1 g/day, and severe renal lesions. Obesity also portends a poor prognosis. A Japanese boy with IgAN showed nephrotic syndrome at presentation. Pathological features resembled those of membranoproliferative glomerulonephritis (MPGN), although IgA deposition differed from MPGN and IgAN. Combination therapy improved renal lesions, but rebound deterioration of proteinuria occurred in this patient, who had marked obesity and hypertension. Serial kidney biopsy specimens were compatible with obesity-related glomerulopathy (ORG). Rebound proteinuria was apparently attributable to ORG rather than relapse and flaring up of IgAN.

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Acknowledgments

The authors wish to thank Dr. A. Kitagawa, who kindly determined the glomerular diameter, and well-trained laboratory staff members for processing kidney biopsy specimens at the Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine.

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Authors and Affiliations

  1. Department of Pediatrics, Saiseikai Toyama Hospital, 33-1 Kusunoki, Toyama, 931-8533, Japan

    Hiro Matsukura

  2. Department of Nephrology, Nagoya Memorial Hospital, Nagoya, Japan

    Masako Sakakibara, Izumi Sakamoto & Miho Tatematsu

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  1. Hiro Matsukura
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  2. Masako Sakakibara
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  3. Izumi Sakamoto
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  4. Miho Tatematsu
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Correspondence to Hiro Matsukura.

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The authors declare that they have no conflict of interest related to the study described in this report.

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Matsukura, H., Sakakibara, M., Sakamoto, I. et al. Proteinuria rebound in IgA nephropathy associated with obesity-related glomerulopathy. CEN Case Rep 5, 131–136 (2016). https://doi.org/10.1007/s13730-015-0208-8

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  • DOI: https://doi.org/10.1007/s13730-015-0208-8

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